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researcher

Deborah Crawford

Lecturer in Bio-Organic Chemistry

Faculty/Dept/School School of Chemistry and Bioscience
(Faculty of Life Sciences)
Emaild.crawford@bradford.ac.uk
Twitter@https://twitter.com/DebbieC16017436
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Biography

Deborah obtained her MSci in Chemistry at Queen’s University Belfast in 2010, she also carried out research at Queen’s University Ionic Liquid Laboratories (QUILL), conducting Friedel Craft reactions in ionic liquids and preparing ionic liquids with antimicrobial properties. Deborah went on to carry out a PhD at the same institution, receiving her PhD in 2015 with a dissertation on the synthesis of diphosphine digold(I) complexes that involved investigation of their structural and optical properties, under the supervision of Dr C. Lagunas. Onwards, she spent one year seconded into the spin out company MOF Technologies Ltd., funded by the EPSRC Impact Acceleration Account, focusing on the manufacture of Metal Organic Frameworks (MOFs). Deborah was then appointed as a Postdoctoral Research Fellow, under the supervision of Professor S. L. James, to investigate synthesis by extrusion. This involves carrying out both organic and inorganic synthesis in the solid state, in the complete absence of solvent, promoting the possibility of making the manufacture of fine chemicals environmentally sustainable. Subsequent to this, Deborah then undertook another Postdoctoral Research Fellowship, with Professor James, investigating new hosts for Porous Liquids. These are novel materials invented by Professor James to incorporate fluidity into porous materials. Deborah continues to be involved in this work. Now, Deborah is a newly appointed Bio-Organic Lecturer (January 2020) in the School of Chemistry and Biosciences at the University of Bradford. Her main research focus i) involves determining the biological activity of metallodrugs prepared mechanochemically, ii) investigating and understanding the mechanism by which solid-state sonochemical reactions proceed and iii) developing a new prototype for the immediate detection of sepsis, with an interface that is user-friendly for care providers. In addition, Deborah is part of the Core Group Management Committee for the EU COST Action 18112, and leads the Work Group focused on Scalability of Mechanochemical Processes. 

Research

Current projects involve: i) determining the biological activity of metallodrugs prepared mechanochemically, ii) investigating and understanding the mechanism by which solid-state sonochemical reactions proceed and iii) developing a new prototype for the immediate detection of sepsis, with an interface that is user-friendly for care providers.  

Publications

Peer Reviewed Journal
TitleContinuous and scalable synthesis of a porous organic cage by twin screw extrusion (TSE) (2020)
AuthorsDeborah Crawford
JournalChemical Science
 
TitleGreener dye synthesis: Continuous, solvent-free synthesis of commodity perylene diimides by Twin Screw Extrusion (2019)
AuthorsDeborah Crawford
JournalAngewandte Chemie - International Edition
 
TitlePapain-catalysed mechanochemical synthesis of oligopeptides by milling and twin-screw extrusion: application in the Julia-Colonna enantioselective epoxidation (2018)
AuthorsArdila-Fierro KJ; Crawford Deborah E; Koerner A; James SL; Bolm C; Hernandez JG
JournalGreen Chemistry
DOIhttps://doi.org/10.1039/C7GC03205F
 
TitleUse of Batch Mixing to Investigate the Continuous Solvent-Free Mechanical Synthesis of OLED Materials by Twin-Screw Extrusion (TSE) (2018)
AuthorsCrawford D.;James S.;McNally T.
JournalACS Sustainable Chemistry and Engineering
DOI10.1021/acssuschemeng.7b02202
 
TitleMechanochemical dehydrocoupling of dimethylamine borane and hydrogenation reactions using Wilkinson's catalyst (2018)
AuthorsSchumacher C; Crawford Deborah E; Raguz B; Glaum R; James SL; Bolm C; Hernandez JG
JournalChemical Communications
DOIhttps://doi.org/10.1039/C8CC04487B
 
TitleTranslating solid state organic synthesis from a mixer mill to a continuous twin screw extruder (2018)
AuthorsCao Q.;Howard J.;Crawford D.;James S.;Browne D.
JournalGreen Chemistry
DOI10.1039/c8gc02036a
 
TitleMechanoenzymatic peptide and amide bond formation (2017)
AuthorsHernandez JG; Ardila-Fierro KJ; Crawford Deborah E; James SL; Bolm C
JournalGreen Chemistry
DOIhttps://doi.org/10.1039/C7GC00615B
 
TitleSolvent-free sonochemistry: Sonochemical organic synthesis in the absence of a liquid medium. (2017)
AuthorsCrawford DE;
JournalBeilstein Journal of Organic Chemistry
DOI10.3762/bjoc.13.179
 
TitleExtrusion - back to the future: Using an established technique to reform automated chemical synthesis. (2017)
AuthorsCrawford DE;
JournalBeilstein Journal of Organic Chemistry
DOI10.3762/bjoc.13.9
 
TitleContinuous multi-step synthesis by extrusion - telescoping solvent-free reactions for greater efficiency. (2017)
AuthorsCrawford DE;Miskimmin CK;Cahir J;James SL;
JournalChemical Communications
DOI10.1039/c7cc06010f
 
TitleFeedback Kinetics in Mechanochemistry: The Importance of Cohesive States. (2017)
AuthorsHutchings BP;Crawford DE;Gao L;Hu P;James SL;
JournalAngewandte Chemie - International Edition
DOI10.1002/anie.201706723
 
TitleOrganic synthesis by Twin Screw Extrusion (TSE): Continuous, scalable and solvent-free (2017)
AuthorsCrawford D.;Miskimmin C.;Albadarin A.;Walker G.;James S.
JournalGreen Chemistry
DOI10.1039/c6gc03413f
 
TitleEfficient continuous synthesis of high purity deep eutectic solvents by twin screw extrusion. (2016)
AuthorsCrawford DE;Wright LA;James SL;Abbott AP;
JournalChemical Communications
DOI10.1039/c5cc09685e
 
TitleRecent Developments in Mechanochemical Materials Synthesis by Extrusion. (2016)
AuthorsCrawford DE;Casaban J;
JournalAdvanced Materials
DOI10.1002/adma.201505352
 
TitleSynthesis by extrusion: continuous, large-scale preparation of MOFs using little or no solvent. (2015)
AuthorsCrawford D;Casaban J;Haydon R;Giri N;McNally T;James SL;
JournalChemical Science
DOI10.1039/c4sc03217a
 
TitleAntimicrobial and antibiofilm activities of 1-alkylquinolinium bromide ionic liquids (2010)
AuthorsBusetti A.;Crawford D.;Earle M.;Gilea M.;Gilmore B.;Gorman S.;Laverty G.;Lowry A.;McLaughlin M.;Seddon K.
JournalGreen Chemistry
DOI10.1039/b919872e
 
Other Publications
Other typeReviews
TitleExtrusion - Back to the future: Using an established technique to reform automated chemical synthesis (2017)
AuthorsCrawford Deborah E
DOIhttps://doi.org/10.3762/bjoc.13.9