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researcher

Colin Wright

Professor of Pharmacognosy

Faculty/Dept/School School of Pharmacy and Medical Sciences
(Faculty of Life Sciences)
Emailc.w.wright@bradford.ac.uk
Telephone +441274 234739

Biography

I started my career as a hospital pharmacist and became interested in tropical diseases as well as traditional medicine while working as a pharmacist in India (1980-1982). This led to my long-term interest in pharmacognosy and research in traditional medicines used in the treatment of infectious diseases and cancer. I have taught pharmacognosy for more than 20 years with the principal aims of highlighting the importance of natural products in medicine & drug discovery as well as revealing their fascinating chemistry and pharmacological effects. When I started at Bradford School of Pharmacy in 1994, the teaching of Pharmacognosy was fairly traditional including analytical microscopy. Working with Dr Peter Linley, I developed this subject area to provide modules that were more relevant to modern pharmacy practice by illustrating through lectures and lab workshops why a knowledge of herbal medicines and natural products is necessary for the practising pharmacist. Similarly, I developed a module on natural products for the (former) M.Sc in Pharmaceutical Services and Medicines Control. Although pharmacognosy as a subject is no longer in the new pharmacy curriculum, I have been able to include some content e.g. in unit FS2 which includes the origins of drugs and eco-pharmacy and a number of applications exercises present problems involving herbal medicines/natural products. Also, herbal medicines is a topic for student selected components and I offer natural product-related laboratory research projects.    My research has focussed mainly on the investigation of traditional medicines used for the treatment of malaria with the aim of identifying lead antimalarial compounds. In collaboration with Bradford’s Institute for Cancer Research I have also investigated plants including marine algae (seaweeds) for their potential to yield anticancer compounds. I also have an interest in anti-TB natural products. My main research achievement has been the study of cryptolepine for which I received funding from WHO and is described in more detail below. I have successfully supervised 20 PhD students whose work, together with the help of many collaborators has resulted in the publication of 98 research papers and more than 100 conference contributions. In addition, I am regularly invited to present my research at conferences and seminars.   I actively participate in two of the research groups in the School of Pharmacy especially in the Medicines Development and Pharmaceutical Science group in which I line manage 7 academic staff and have a role in facilitating the group’s research ambitions and strategy.

Publications

Peer Reviewed Journal
TitleEvaluation of Alangium lamarckii bark for antiplasmodial and cytotoxic constituents and isolation of a novel tubulosine analogue (2018)
AuthorsKantamreddi V.;Marston G.;Shnyder S.;Wright C.
JournalNatural product communications
 
TitleIdentification of cryptolepine metabolites in rat and human hepatocytes and metabolism and pharmacokinetics of cryptolepine in Sprague Dawley rats (2017)
AuthorsForkuo, A.D.; Ansah, C.; Pearson, D.; Gertsch, W.; Cirello, A.; Amaral, A.; Spear, J.; Wright, Colin W.; Rynn, C.
 
TitleIdentification of compounds with cytotoxic activity from the leaf of the Nigerian medicinal plant, Anacardium occidentale L. (Anacardiaceae) (2017)
AuthorsTaiwo, Bamigboye J.; Fatokun, Amos A.; Olubiyi, O.O.; Bamigboye-Taiwo, O.T.; van Heerden, F.R.; Wright, Colin W.
 
TitleIn vitro anti-malarial interaction and gametocytocidal activity of cryptolepine (2017)
AuthorsForkuo, A.D.; Ansah, C.; Mensah, K.B.; Annan, K.; Gyan, B.; Theron, A.; Mancama, D.; Wright, Colin W.
 
TitleSynthesis and biological evaluation of N-cyanoalkyl-, Naminoalkyl-, and N-guanidinoalkyl-substituted 4-aminoquinoline derivatives as potent, selective, brain permeable antitrypanosomal agents (2016)
AuthorsSola, I.; Artigas, A.; Taylor, M.C.; Perez-Areales, F.J.; Viayna, E.; Clos, M.V.; Perez, B.; Wright, Colin W.; Kelly, J.M.; Muñoz-Torrero, D.
 
TitleA new embelin from the mangrove Aegiceras corniculatum. (2015)
AuthorsThota, S.P.R.; Sarma, N.S.; Murthy, Y.L.N.; Kantamreddi, Venkata Siva Satya Narayana; Wright, Colin W.
 
TitleAnticandida Agents from a Tanzanian Plant Albizia anthelmintica. (2015)
AuthorsRunyoro, D.K.B.; Joseph, C.C.; Ngassapa, O.D.; Darokar, M.P.; Srivastava, S.K.; Matee, M.I.N.; Wright, Colin W.
 
TitleClerodane diterpenes from Polyalthia longifolia (Sonn) Thw. var. pendula: Potential antimalarial agents for drug resistant Plasmodium falciparum infection. (2015)
AuthorsGbedema, Stephen Y.; Bayor, M.T.; Annan, K.; Wright, Colin W.
 
TitlePrenylated flavanone derivatives isolated from Erythrina addisoniae are potent inducers of apoptotic cell death (2015)
AuthorsPassreiter, C.M.; Suckow-Schnitker, A-K.; Kulawik, A.; Addae-Kyereme, Jonathan A.; Wright, Colin W.; Wätjen, W.
 
TitleSynthesis, biological profiling and mechanistic studies of 4-aminoquinoline-based heterodimeric compounds with dual trypanocidal–antiplasmodial activity. (2015)
AuthorsSola, I.; Castellà, S.; Viayna, E.; Galdeano, C.; Taylor, M.C.; Gbedema, Stephen Y.; Pérez, B.; Clos, M.V.; Jones, D.C.; Fairlamb, A.H.; Wright, Colin W.; Kelly, J.M.; Muñoz-Torrero, D.
 
TitleSynthesis and antiprotozoal activity of oligomethylene- and p-phenylene-bis(methylene)-linked bis(+)-huprines. (2014)
AuthorsSola, I.; Artigas, A.; Taylor, M.C.; Gbedema, Stephen Y.; Perez, B.; Clos, M.V.; Wright, Colin W.; Kelly, J.M.; Muñoz-Torrero, D.
 
TitleSynthesis and antiprotozoal activity of oligomethylene- and p-phenylene-bis(methylene)-linked bis(+)-huprines (2014)
AuthorsSola I.;Artigas A.;Taylor M.;Gbedema S.;Pérez B.;Clos M.;Wright C.;Kelly J.;Muñoz-Torrero D.
JournalBioorganic and Medicinal Chemistry Letters
DOI10.1016/j.bmcl.2014.10.025
 
TitleInhibition of Neuroinflammation in LPS-Activated Microglia by Cryptolepine. (2013)
AuthorsOlajide, O.A.; Bhatia, H.S.; de Oliveira, A.C.P.; Wright, Colin W.; Fiebich, B.L.
DOIOlajide, O.A., Bhatia, H., A.C., de Oliveira, A.C.P., Wright, C.W. and Fiebich, B.L. (2013) Inhibition of neuroinflammation in LPS-activated microglia by cryptolepine. Evidence-Based Complementary and Alternative Medicine, Article ID 459723. http://dx.doi.org/10.1155/2013/459723
 
TitleAnti-neuroinflammatory properties of synthetic cryptolepine in human neuroblastoma cells: Possible involvement of NF-κB and p38 MAPK inhibition. (2013)
AuthorsOlajide, O.A.; Bhatia, H.S.; de Oliveira, A.C.P.; Wright, Colin W.; Fiebich, B.L.
 
TitleCajachalcone: An Antimalarial Compound from Cajanus cajan Leaf Extract (2013)
AuthorsAjaiyeoba, E.O.; Ogbole, O.O.; Abiodun, O.O.; Ashidi, J.S.; Houghton, P.J.; Wright, Colin W.
 
TitleScreening indian plant species for antiplasmodial properties - Ethnopharmacological compared with random selection (2012)
AuthorsKantamreddi V.;Wright C.
JournalPhytotherapy Research
DOI10.1002/ptr.4651
 
TitleMetabolism of cryptolepine and 2-fluorocryptolepine by aldehyde oxidase (2012)
AuthorsStell, J.G.P.;Wheelhouse, R.T.;Wright, C.W.;
JournalJournal of Pharmacy and Pharmacology
DOI10.1111/j.2042-7158.2011.01408.x
 
TitleTraditional remedies: an ally in the fight against infectious diseases? (2012)
AuthorsWright, Colin W.
 
TitleComplete NMR assignments of tubulosine (2012)
AuthorsKantamreddi, Venkata Siva Satya Narayana; Wright, Colin W.
 
TitleAntileishmanial activity of cryptolepine analogues and apoptotic effects of 2,7-dibromocryptolepine against Leishmania donovani promastigotes. (2012)
AuthorsHazra, S.; Ghosh, S.; Debnath, S.; Seville, Scott; Prajapati, V.K.; Wright, Colin W.; Sundar, S.; Hazra, B.
 
TitleMetabolism of cryptolepine and 2-fluorocryptolepine by aldehyde oxidase (2012)
AuthorsStell, J. Godfrey P.; Wheelhouse, Richard T.; Wright, Colin W.
 
TitleScreening Indian plant species for antiplasmodial properties – ethnopharmacological compared to random selection. (2012)
AuthorsKantamreddi, Venkata Siva Satya Narayana; Wright, Colin W.
 
TitleHuprines as a new family of dual acting trypanocidal-antiplasmodial agents (2011)
AuthorsDefaux J.;Sala M.;Formosa X.;Galdeano C.;Taylor M.;Alobaid W.;Kelly J.;Wright C.;Camps P.;Muñoz-Torrero D.
JournalBioorganic and Medicinal Chemistry
DOI10.1016/j.bmc.2011.01.028
 
TitleLow temperature X-ray crystallographic structure of the antiplasmodial compound 5-N-hydroxyethanequindoline hydrochloride 0.5CH3OH (2011)
AuthorsHampson H.;Ho C.;Palmer R.;Potter B.;Helliwell M.;Wright C.
JournalJournal of Chemical Crystallography
DOI10.1007/s10870-011-0169-5
 
TitleEffects of the antimalarial compound cryptolepine and its analogues in human lymphocytes and sperm in the Comet assay (2011)
AuthorsGopalan, Rajendran C.; Emerce, E.; Wright, Colin W.; Karahalil, B.; Karakaya, A.E.; Anderson, Diana
 
TitleHuprines as a new family of dual acting trypanocidal–antiplasmodial agents (2011)
AuthorsDefaux, J.; Sala, M.; Formosa, X.; Galdeano, C.; Taylor, M.C.; Kelly, J.M.; Wright, Colin W.; Camps, P.; Muñoz-Torrero, D.; Alobaid, Waleed A.A.
 
TitleWhole plant extracts versus single compounds for the treatment of malaria: synergy and positive interactions. (2011)
AuthorsRasoanaivo, P.; Wright, Colin W.; Willcox, M.L.; Gilbert, B.
 
TitleCryptolepine-Induced Cell Death of Leishmania donovani Promastigotes Is Augmented by Inhibition of Autophagy. (2011)
AuthorsSengupta, S.; Chowdhury, S.; BoseDasgupta, S.; Wright, Colin W.; Majumder, H.K.
 
TitleLow Temperature X-Ray Crystallographic Structure of the Antiplasmodial Compound 5-N-Hydroxyethanequindoline Hydrochloride 0.5CH3OH. (2011)
AuthorsHampson, Hannah C.; Ho, Chung Y.; Palmer, R.A.; Potter, B.S.; Helliwell, M.; Wright, Colin W.
 
TitleRecent developments in research on terrestrial plants used for the treatment of malaria. (2010)
AuthorsWright, Colin W.
 
TitleNew polyhydroxy sterols from the marine sponge Callyspongia fibrosa (Ridley and Dendly). (2010)
AuthorsRao, T.S.P.; Sarma, N.S.; Murthy, Y.L.N.; Kantamreddi, Venkata Siva Satya Narayana; Wright, Colin W.; Parameswaran, P.S.
 
TitleAnti-inflammatory properties of cryptolepine. (2010)
AuthorsOlajide, O.A.; Ajayi, A.A.; Wright, Colin W.
 
TitleScreening of Tanzanian medicinal plants against Plasmodium falciparum and human immunodeficiency virus. (2010)
AuthorsMaregesi, S.; Van Miert, S.; Pannecouque, C.; Feiz-Haddad, M.H.; Hermans, N.; Wright, Colin W.; Vlietinck, A. J.; Aspers, S.; Pieters, L.
 
TitleAncient Chinese methods are remarkably effective for the preparation of artemisinin-rich extracts of Qing Hao with potent antimalarial activity. (2010)
AuthorsWright, Colin W.; Linley, Peter A.; Brun, R.; Wittlin, S.; Hsu, E.
 
TitlePhytotherapy used in Orissa State India, for treating malaria. (2009)
AuthorsKantamreddi, Venkata Siva Satya Narayana; Parida, S.; Kommula, S.M.; Wright, Colin W.
 
TitleCharacterization of the cytotoxic activity of the indoloquinoline alkaloid cryptolepine in human tumour cell lines and primary cultures of tumour cells from patients. (2009)
AuthorsLaryea, D.; Isaksson, A.; Wright, Colin W.; Larsson, R.; Nygren, P.
 
TitleEvaluation of cryptolepine and huperzine derivatives as lead compounds towards new agents for the treatment of human African Trypanosomiasis. (2009)
AuthorsOluwafemi, A.J.; Okanla, O.; Camps, P.; Muñoz-Torrero, D.; Mackey, Z.B.; Chiang, P.K.; Seville, Scott; Wright, Colin W.
 
TitleGenomewide expression profiling of cryptolepine-induced toxicity in Saccharomyces cerevisiae (2008)
AuthorsRojas M.;Wright C.;Piña B.;Portugal J.
JournalAntimicrobial Agents and Chemotherapy
DOI10.1128/AAC.00532-08
 
TitleA cytotoxic diterpenoid from Croton membranaceus, the major constituent of anticancer herbal formulations used in Ghana (2008)
AuthorsBayor, M.T.;Ayim, J.S.K.;Marston, G.;Phillips, R.M.;Shnyder, S.D.;Wheelhouse, R.T.;Wright, C.W.;
JournalNatural product communications
 
TitleInvestigation of Indian Diospyros species for antiplasmodial properties (2008)
AuthorsKantamreddi V.;Wright C.
JournalEvidence-based Complementary and Alternative Medicine
DOI10.1093/ecam/nem019
 
TitlePrenylated flavonoid derivatives from the bark of Erythrina addisoniae. (2008)
AuthorsWatjen, W.; Suckow-Schnitker, A-K.; Rohrig, R.; Kulawik, A.; Addae-Kyereme, Jonathan A.; Wright, Colin W.; Passreiter, C.M.
 
TitleAntiplasmodial compounds from Cassia siamea stem bark extract. (2008)
AuthorsAjaiyeoba, E.O.; Ashidi, J.S.; Okpako, Larry Commander; Houghton, P.J.; Wright, Colin W.
 
TitleA cytotoxic diterpenoid from Croton membranaceus, the major constituent of anticancer herbal formulations in Ghana (2008)
AuthorsBayor, M.T.; Ayim, J.S.K.; Marston, G.; Phillips, Roger M.; Shnyder, Steven D.; Wheelhouse, Richard T.; Wright, Colin W.
 
TitleX-ray crystallographic structure of the potent antiplasmodial compound 2,7-dibromocryptolepine acetic acid solvate. (2008)
AuthorsPotter, B.S.; Lisgarten, J.N.; Pitts, J.E.; Palmer, R.A.; Wright, Colin W.
 
TitleStructure of the antiplasmodial compound 7,9-dinitrocryptolepine hydrochloride methanol solvate. (2008)
AuthorsLisgarten, J.N.; Potter, B.S.; Pitts, J.E.; Palmer, R.A.; Wright, Colin W.
 
TitleGenomewide expression profiling of the cryptolepine-induced toxicity in Saccharomyces cerevisiae. (2008)
AuthorsRojas, M.; Wright, Colin W.; Pina, B.; Portugal, J.
 
TitleSynthetic cryptolepine inhibits DNA binding of NF-κB (2007)
AuthorsOlajide O.;Heiss E.;Schachner D.;Wright C.;Vollmar A.;Dirsch V.
JournalBioorganic and Medicinal Chemistry
DOI10.1016/j.bmc.2006.10.018
 
TitleRecent developments in naturally derived antimalarials: Cryptolepine analogues (2007)
AuthorsWright C.
JournalJournal of Pharmacy and Pharmacology
DOI10.1211/jpp.59.6.0017
 
TitlePterocarpans phaseollin and neorautenol isolated from Erythrina addisoniae induce apoptotic cell death accompanied by inhibition of ERK phosphorylation (2007)
AuthorsWätjen W.;Kulawik A.;Suckow-Schnitker A.;Chovolou Y.;Rohrig R.;Ruhl S.;Kampkötter A.;Addae-Kyereme J.;Wright C.;Passreiter C.
JournalToxicology
DOI10.1016/j.tox.2007.09.010
 
TitleSynthesis of cryptolepine analogues as potential bioreducible anticancer agents (2007)
AuthorsSeville S.;Phillips R.;Shnyder S.;Wright C.
JournalBioorganic and Medicinal Chemistry
DOI10.1016/j.bmc.2007.06.062
 
TitleSeasonal variation in bromophenol content of Polysiphonia lanosa (2006)
AuthorsShoeib N.;Bibby M.;Blunden G.;Linley P.;Swaine D.;Wright C.
JournalNatural product communications
 
TitleSynthesis of novel halogenated cryptolepine analogues (2006)
AuthorsGouni S.;Carrington S.;Wright C.
JournalJournal of Heterocyclic Chemistry
DOI10.1002/jhet.5570430126
 
TitleSynthesis of some cryptolepine analogues, assessment of their antimalarial and cytotoxic activities, and consideration of their antimalarial mode of action. (2005)
AuthorsWright, Colin W.; Onyeibor, O.; Phillips, Roger M.; Shnyder, Steven D.; Croft, S.L.; Dodson, Hilary I.
 
TitleIn vitro anti-plasmodial and cytotoxic activities of plants used as antimalarial agents in the southwest Nigerian ethnomedicine (2005)
AuthorsAjaiyeoba E.;Bolaji O.;Akinboye D.;Falade C.;Gbotosho G.;Ashidi J.;Okpako L.;Oduola O.;Falade M.;Itiola O.;Houghton P.;Wright C.;Ogundahunsi O.;Oduola A.
JournalJournal of Natural Remedies
 
TitlePhytochemistry and preliminary biological evaluation of Cyathostemma argenteum, a Malaysian plant used traditionally for the treatment of breast cancer (2004)
AuthorsKhamis S.;Bibby M.;Brown J.;Cooper P.;Scowen I.;Wright C.
JournalPhytotherapy Research
DOI10.1002/ptr.1318
 
TitleAntimalarial ethnobotany: In vitro antiplasmodial activity of seven plants identified in the Nigerian Middle Belt (2004)
AuthorsAjaiyeoba E.;Ashidi J.;Abiodun O.;Okpako L.;Ogbole O.;Akinboye D.;Falade C.;Bolaji O.;Gbotosho G.;Falade M.;Itiola O.;Houghton P.;Wright C.;Oduola A.
JournalPharmaceutical Biology
DOI10.1080/13880200490902455
 
TitleAntiplasmodial principles from Cassia nigricans (2004)
AuthorsObodozie O.;Okpako L.;Tarfa F.;Orisadipe A.;Okogun J.;Inyang U.;Ajaiyeoba E.;Wright C.
JournalPharmaceutical Biology
DOI10.1080/13880200490902545
 
TitleIn-vitro cytotoxic activities of the major bromophenols of the red alga Polysiphonia lanosa and some novel synthetic isomers (2004)
AuthorsShoeib N.;Bibby M.;Blunden G.;Linley P.;Swaine D.;Wheelhouse R.;Wright C.
JournalJournal of Natural Products
DOI10.1021/np0305268
 
TitleCryptolepine hydrochloride: A potent antimycobacterial alkaloid derived from Cryptolepis sanguinolenta (2003)
AuthorsGibbons S.;Fallah F.;Wright C.
JournalPhytotherapy Research
DOI10.1002/ptr.1284
 
TitleEnhancement of the Antiplasmodial Activity of Quassin by Transformation into a γ-Lactone (2003)
AuthorsLang'at-Thoruwa C.;Kirby G.;Phillipson J.;Warhurst D.;Watt R.;Wright C.
JournalJournal of Natural Products
 
TitleEnhancement of the antiplasmodial activity of quassin by transformation into a gamma-lactone. (2003)
AuthorsWright, Colin W.; Kirby, G.C; Phillipson, J.D; Warhurst, D.C.; Lang'at-Thoruwa, C.; Watt, R.A.
 
TitleEvaluation of Some Egyptian Plant Species for in vitro Antimycobacterial and Cytotoxic Activities (2003)
AuthorsAbou El Seoud K.;Bibby M.;Shoeib N.;Wright C.
JournalPharmaceutical Biology
DOI10.1076/phbi.41.6.463.17831
 
TitleCorrelation of hyperforin content of Hypericum perforatum (St John's Wort) extracts with their effects on alcohol drinking in C57BL/6J mice: A preliminary study (2003)
AuthorsWright C.;Gott M.;Grayson B.;Hanna M.;Smith A.;Sunter A.;Neill J.
JournalJournal of Psychopharmacology
DOI10.1177/0269881103174018
 
TitleThe evaluation of forty-three plant species for in vitro antimycobacterial activities; isolation of active constituents from Psoralea corylifolia and Sanguinaria canadensis (2002)
AuthorsNewton S.;Lau C.;Gurcha S.;Besra G.;Wright C.
JournalJournal of Ethnopharmacology
DOI10.1016/S0378-8741(01)00350-6
 
TitleIsolation and in vitro antiplasmodial activities of alkaloids from Teclea trichocarpa: In vivo antimalarial activity and x-ray crystal structure of normelicopicine (2002)
AuthorsMuriithi M.;Abraham W.;Addae-Kyereme J.;Scowen I.;Croft S.;Gitu P.;Kendrick H.;Njagi E.;Wright C.
JournalJournal of Natural Products
DOI10.1021/np0106182
 
TitleThe antimalarial and cytotoxic drug cryptolepine intercalates into dna at cytosine-cytosine sites (2002)
AuthorsLisgarten J.;Coll M.;Portugal J.;Wright C.;Aymami J.
JournalNature Structural Biology
DOI10.1038/nsb729
 
TitleAntiplasmodial activities of some Ghanaian plants traditionally used for fever/malaria treatment and of some alkaloids isolated from Pleiocarpa mutica; in vivo antimalarial activity of pleiocarpine (2001)
AuthorsAddae-Kyereme J.;Croft S.;Kendrick H.;Wright C.
JournalJournal of Ethnopharmacology
DOI10.1016/S0378-8741(01)00212-4
 
TitleSynthesis and evaluation of cryptolepine analogues for their potential as new antimalarial agents. (2001)
AuthorsWright, Colin W.; Addae-Kyereme, Jonathan A.; Breen, Anthony G.; Brown, John E.; Cox, Marlene F.; Croft, S.L.; Gokcek, Yaman; Kendrick, H.; Phillips, Roger M.; Pollet, Pamela L.
 
TitleThe antimalarial and cytotoxic drug cryptolepine intercalates into DNA at cytosine-cytosine sites. (2001)
AuthorsLisgarten, J.N.; Coll, M.; Portugal, J.; Wright, Colin W.; Aymami, J.
 
TitleIn-vitro antimycobacterial screening of some plant species used in traditional medicine for the treatment of tuberculosis (2000)
AuthorsNewton S.;Lau C.;Wright C.
JournalJournal of Pharmacy and Pharmacology
 
TitleIn-vitro antiplasmodial and cytotoxic activities of some British species of marine algae (2000)
AuthorsShoeib N.;Bibby M.;Cooper P.;Blunden G.;Wright C.
JournalJournal of Pharmacy and Pharmacology
 
TitleIn vitro antiplasmodial, antiamoebic, and cytotoxic activities of some monomeric isoquinoline alkaloids (2000)
AuthorsWright C.;Marshall S.;Russell P.;Anderson M.;Phillipson J.;Kirby G.;Warhurst D.;Schiff J.
JournalJournal of Natural Products
DOI10.1021/np000144r
 
TitleSynthesis and antiplasmodial activities of some halogenated cryptolepine derivatives (2000)
AuthorsWright C.;Addae-Kyereme J.;Brown J.;Cox M.;Gokcek Y.;Pollet P.
JournalJournal of Pharmacy and Pharmacology
 
TitleAntiplasmodial and antiamoebic activities of medicinal plants from Sierra Leone (2000)
AuthorsMarshall S.;Russell P.;Phillipson J.;Kirby G.;Warhurst D.;Wright C.
JournalPhytotherapy Research
DOI10.1002/1099-1573(200008)14:5<356::AID-PTR636>3.0.CO;2-Z
 
TitleIn-vitro cytotoxicity and thermodenaturation studies for cryptolepine and analogues (2000)
AuthorsGokcek Y.;Pollet P.;Wright C.;Brown J.
JournalJournal of Pharmacy and Pharmacology
 
TitleSesquiterpene lactones from Neurolaena oaxacana (1999)
AuthorsPassreiter C.;Sandoval-Ramirez J.;Wright C.
JournalJournal of Natural Products
DOI10.1021/np990038t
 
TitleStructure of the tetraphenyl borate complex of the indoloquinoline alkaloid cryptolepine (1999)
AuthorsWright C.;Philpson J.;Lisgarten J.;Palmer R.
JournalJournal of Chemical Crystallography
DOI10.1023/A:1009519211938
 
TitleAlkaloids from Narcissus cantabricus (1995)
AuthorsBastida J.;Contreras J.;Codina C.;Wright C.;David Phillipson J.
JournalPhytochemistry
DOI10.1016/0031-9422(95)00448-G
 
TitleSelective antiprotozoal activity of some Strychnos alkaloids (1994)
AuthorsWright C.;Allen D.;Cai Y.;Chen Z.;Phillipson J.;Kirby G.;Warhurst D.;Tits M.;Angenot L.
JournalPhytotherapy Research
DOI10.1002/ptr.2650080306
 
TitleToward the chemical ecology of medicinal plant use in chimpanzees: The case of Vernonia amygdalina, a plant used by wild chimpanzees possibly for parasite-related diseases (1994)
AuthorsOhigashi H.;Huffman M.;Izutsu D.;Koshimizu K.;Kawanaka M.;Sugiyama H.;Kirby G.;Warhurst D.;Allen D.;Wright C.;David Phillipson J.;Timon-David P.;Delmas F.;Elias R.;Balansard G.
JournalJournal of Chemical Ecology
DOI10.1007/BF02059596
 
TitleIn vitro antiplasmodial, antiamoebic, and cytotoxic activities of a series of bisbenzylisoquinoline alkaloids (1994)
AuthorsMarshall S.;Russell P.;Wright C.;Anderson M.;Phillipson J.;Kirby G.;Warhurst D.;Schiff P.
JournalAntimicrobial Agents and Chemotherapy
DOI10.1128/AAC.38.1.96
 
TitleAntiprotozoal activities of Centipeda minima (1994)
AuthorsYu H.;Wright C.;Cai Y.;Yang S.;Phillipson J.;Kirby G.;Warhurst D.
JournalPhytotherapy Research
DOI10.1002/ptr.2650080713
 
TitleQuassinoids Exhibit Greater Selectivity Against Plasmodium Falciparum Than Against Entamoeba Histolytica, Giardia Intestinalis Or Toxoplasma Gondii In Vitro (1993)
AuthorsWRIGHT C.;ANDERSON M.;ALLEN D.;PHILLIPSON J.;KIRBY G.;WARHURST D.;CHANG H.
JournalJournal of Eukaryotic Microbiology
DOI10.1111/j.1550-7408.1993.tb04910.x
 
TitleAlstonia species: are they effective in malaria treatment? (1993)
AuthorsWright C.;Allen D.;Phillipson J.;Kirby G.;Warhurst D.;Massiot G.;Le Men-Olivier L.
JournalJournal of Ethnopharmacology
DOI10.1016/0378-8741(93)90087-L
 
TitlePharmacy Education: Understanding drug abuse (1993)
AuthorsWright, C.W.
JournalPharmaceutical Journal
 
TitleAlkaloids from Cephaelis dichroa (1993)
AuthorsSolis P.;Wright C.;Gupta M.;Phillipson J.
JournalPhytochemistry
DOI10.1016/0031-9422(93)85033-N
 
TitleIn vitro antimalarial and cytotoxic activities of semisynthetic derivatives of brusatol (1993)
AuthorsAllen D.;Toth I.;Wright C.;Kirby G.;Warhurst D.;Phillipson J.
JournalEuropean Journal of Medicinal Chemistry
DOI10.1016/0223-5234(93)90143-3
 
TitleA microwell cytotoxicity assay using Artemia salina (brine shrimp) (1993)
AuthorsSolis P.;Wright C.;Anderson M.;Gupta M.;Phillipson J.
JournalPlanta Medica
 
TitleParasitological and microbiological evaluation of Mixe Indian medicinal plants (Mexico). (1992)
AuthorsHeinrich M;Kuhnt M;Wright CW;Rimpler H;Phillipson JD;Schandelmaier A;Warhurst DC;
JournalJournal of Ethnopharmacology
 
TitleDetermination of anti-giardial activity in vitro by means of soluble formazan production (1992)
AuthorsWright C.;Melwani S.;David Phillipson J.;Warhurst D.
JournalTransactions of the Royal Society of Tropical Medicine and Hygiene
DOI10.1016/0035-9203(92)90093-R
 
TitleParasitological and microbiological evaluation of Mixe Indian medicinal plants (Mexico) (1992)
AuthorsHeinrich M.;Kuhnt M.;Wright C.;Rimpler H.;Phillipson J.;Schandelmaier A.;Warhurst D.
JournalJournal of Ethnopharmacology
DOI10.1016/0378-8741(92)90063-W
 
TitleA new alkaloid from the roots of alstonia angustifolia (1992)
AuthorsSaid I.;Din L.;Yusoff N.;Wright C.;Cai Y.;Phillipson J.
JournalJournal of Natural Products
DOI10.1021/np50087a025
 
TitleIn vitro antiamoebic and antiplasmodial activities of alkaloids isolated from Alstonia angustifolia roots (1992)
AuthorsWright C.;Allen D.;Cai Y.;Phillipson J.;Said I.;Kirby G.;Warhurst D.
JournalPhytotherapy Research
DOI10.1002/ptr.2650060303
 
TitleMolecular modelling of usambarensine, tubulosine and emetine, three cytotoxic amoebicide alkaloids (1991)
AuthorsQuetin-Leclercq J.;Dupont L.;Wright C.;Phillipson J.;Warhurst D.;Angenot L.
JournalJournal de Pharmacie de Belgique
 
TitleAntiamoebic and antiplasmodial activities of alkaloids isolated from Strychnos usambarensis (1991)
AuthorsWright C.;Bray D.;O'Neill M.;Warhurst D.;Phillipson J.;Quetin-Leclercq J.;Angenot L.
JournalPlanta Medica
 
TitleCan ethnopharmacology contribute to the development of antimalarial agents? (1991)
AuthorsDavid Phillipson J.;Wright C.
JournalJournal of Ethnopharmacology
DOI10.1016/0378-8741(91)90113-R
 
TitleAntiamoebic and antiplasmodial activities of alkaloids isolated from Strychnos usambarensis. (1991)
AuthorsWright CW;Bray DH;O'Neill MJ;Warhurst DC;Phillipson JD;Quetin-Leclercq J;Angenot L;
JournalPlanta Medica
DOI10.1055/s-2006-960112
 
TitleUse of microdilution to assess in vitro antiamoebic activities of Brucea javanica fruits, Simarouba amara stem, and a number of quassinoids (1988)
AuthorsWright C.;O'Neill M.;Phillipson J.;Warhurst D.
JournalAntimicrobial Agents and Chemotherapy
DOI10.1128/AAC.32.11.1725
 
TitlePlants as sources of antimalarial drugs, part 6: Activities of Simarouba amara fruits (1988)
AuthorsO'Neill M.;Bray D.;Boardman P.;Wright C.;David Phillipson J.;Warhurst D.;Gupta M.;Correya M.;Solis P.
JournalJournal of Ethnopharmacology
DOI10.1016/0378-8741(88)90126-2
 
TitleUse of microdilution to assess in vitro antiamoebic activities of Brucea javanica fruits, Simarouba amara stem, and a number of quassinoids. (1988)
AuthorsWright CW;O'Neill MJ;Phillipson JD;Warhurst DC;
JournalAntimicrobial Agents and Chemotherapy