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researcher

Dr Chris Sutton

Senior Lecturer

Faculty/Dept/School School of Chemistry and Bioscience
(Faculty of Life Sciences)
Emailc.w.sutton@bradford.ac.uk
Telephone +441274 236480

Biography

Chris Sutton obtained his B.Sc. degree and Ph.D. in Biochemistry from University of Liverpool, with combined studies in the Department of Plant Molecular Biology, University of California, Berkeley. He was then a Postdoctoral Research Scientist at the London School of Hygiene and Tropical Medicine, investigating the mechanisms of pathogenicity of Vibrio cholerae. He joined the premier of UK biotechnology company, Celltech Limited, as a Senior Scientist in Protein Biochemistry purifying novel proteins of therapeutic interest, and was later promoted to Group Leader of Analytical Biochemistry. With the emergence of mass spectrometry for protein characterisation, he moved to ThermoFinnigan and developed novel applications for matrix assisted laser desorption mass spectrometry (MALDI MS) including pioneering work in proteomics. He joined Kratos Analytical as MALDI MS Product Manager and was responsible for the marketing and promotion, including co-ordinating the research activity of a worldwide group of 25 application specialists who were developing MALDI MS solutions for the future. He was subsequently promoted to Business Manager for the product lines with a staff of 50, doubling revenues during this time to 10 million USD per annum. Since August 2005, Chris has joined the Institute of Cancer Therapeutics in the University of Bradford as Senior Lecturer in Proteomics Chemistry and Mass Spectrometry. With the support of Yorkshire Cancer Research, he has develop three key areas of research (1) identification of new proteins as candidate diagnostic biomarkers, (2) identification of proteins affected by the action of anticancer drugs and (3) identification of new target proteins for anticancer drug development. He has developed collaborations with academic groups in Hull, York, Sheffield and Leeds within the UK and Toronto, Cyprus, Pakistan internationally.  

Research

Proteomics and mass spectrometry.  Current Projects.

  • Identification of biomarkers for the early detection of breast cancer 
  • Characterisation of drug resistance mechanisms in colorectal and breast cancer
  • Proteomic stratification of head and neck cancers
  • Profiling cytochrome P450s isoforms in cancer tissues and cell lines
  • Influence of microenvironmental changes on cancer cell phenotype
  • investigation and characterisation of close proximity derived liquid biopsies/biofluids

Professional activities

  • Liverpool - PhD
  • Liverpool - BSc (Hons)
  • 01-JAN-05: University of Bradford, Bradford, West Yorkshire - Senior Lecturer in Proteomics and Mass Spectrometry
  • 01-JAN-05: Oxford Instruments, Abingdon, Oxon - Proteomics and Mass Spectrometry Consultant
  • 01-JAN-01: Shimadzu Corporation, Trafford, Manchester - Mass Spectrometry Business Manager
  • 01-JAN-98: Shimadzu Corporation, Trafford, Manchester - Mass Spectrometry Product Manager
  • 01-JAN-96: Thermo Scientific, Hemel Hempstead, Herts. - Product Manager
  • 01-JAN-91: Thermo Scientific, Hemel Hempstead, Herts. - Senior Research Biochemist
  • 01-JAN-89: Celltech Limited, Slough, Berks. - Group Leader of Analytical Biochemistry
  • 01-JAN-85: Celltech Limited, Slough, Berks. - Senior Research Scientist
  • 01-JAN-82: London School of Hygiene and Tropical Medicine, London - Wellcome Foundation Postdoctoral Research Scientist
  • Other: ICT Health and Safety Representative
  • Director: A Director of the British Society of Proteomics Research

Publications

Peer Reviewed Journal
TitleProteomics analysis of colon cancer progression (2019)
AuthorsSaira Saleem, Sahrish Tariq, Iffat Aleem, Sadr-ul Shaheed, Muhammad Tahseen, Aribah Atiq, Sadia Hassan, Muhammad Abu Bakar, Shahid Khattak, Aamir Ali Syed, Asad Hayat Ahmad, Mudassar Hussain, Muhammed Aasim Yusuf and Chris Sutton
JournalClinical Proteomics
DOIhttps://doi.org/10.1186/s12014-019-9264-y
 
TitleEvaluation of nipple aspirate fluid as a diagnostic tool for early detection of breast cancer (2018)
AuthorsShaheed, Sadr-ul; Tait, C.; Kyriacou, K.; Linforth, R.; Salhab, M.; Sutton, Chris W.
 
TitleStem Cell Organoids in Primary Cultures of Human Non-Malignant and Malignant Colon (2017)
AuthorsTariq, S.; Tahseen, M.; Hassan, M.; Masood, M.A.; Khattak, S.; Syed, A.A.; Ahmad, A.H.; Hussain, M.; Yusuf, M.A.; Sutton, Chris W.
 
TitleNipple aspirate fluid - a liquid biopsy for diagnosing breast health (2017)
AuthorsShaheed, Sadr-ul; Tait, C.; Kyriacou, K.; Mullarkey, J.; Burrill, W.; Patterson, Laurence H.; Linforth, R.; Salhab, M.; Sutton, Chris W.
 
TitleRational Development of Novel Activity Probes for the Analysis of Human Cytochromes P450. (2016)
AuthorsSellars JD;Skipsey M;Sadr-Ul-Shaheed ;Gravell S;Abumansour H;Kashtl G;Irfan J;Khot M;Pors K;Patterson LH;Sutton CW;
JournalChemMedChem
DOI10.1002/cmdc.201600134
 
TitleRational development of novel activity probes for the analysis of human cytochromes P450 (2016)
AuthorsSellars, J.D.; Skipsey, M.; Sadr-ul-Shaheed; Gravell, Sebastian; Abumansour, Hamza M.A.; Kashtl, Ghasaq; Irfan, Jawaria; Khot, Mohamed; Pors, Klaus; Patterson, Laurence H.; Sutton, Chris W.
 
TitleThin-layer chromatography/matrix-assisted laser desorption/ionisation mass spectrometry and matrix-assisted laser desorption/ionisation mass spectrometry imaging for the analysis of phospholipids in LS174T colorectal adenocarcinoma xenografts treated with the vascular disrupting agent DMXAA (2015)
AuthorsBatubara, A.; Carolan, V.A.; Loadman, Paul M.; Sutton, Chris W.; Shnyder, Steven D.; Clench, M.R.
JournalRapid Communications In Mass Spectrometry
DOIdoi.org/10.1002/rcm.7223
 
TitlePatterns of cancer cell sphere formation in primary cultures of human oral tongue squamous cell carcinoma and neck nodes (2014)
AuthorsSaleem, Saira; Jamshed, A.; Faisal, S.; Hussain, R.; Tahseen, M.; Loya, A.; Sutton, Chris W.
 
TitleIdentification of Stage-Specific Breast Markers using Quantitative Proteomics (2013)
AuthorsShaheed, Sadr-ul; Rustogi, Nitin; Scally, Andy J.; Wilson, J.; Thygesen, H.; Loizidou, M.A.; Hadjisavvas, A.; Hanby, A.; Speirs, V.; Loadman, Paul M.; Linforth, R.; Kyriacou, K.; Sutton, Chris W.
 
TitleTargeting of Hypoxia in AQ4N-treated Tumour Xenografts by MALDI-Ion Mobility Separation-Mass Spectrometry Imaging (2013)
AuthorsDjidja, M-C.; Francese, S.; Claude, E.; Loadman, Paul M.; Sutton, Chris W.; Shnyder, Steven D.; Cooper, Patricia A.; Patterson, Laurence H.; Carolan, V.A.; Clench, M.R.
 
TitleCharacterization of Changes in the Proteome in Different Regions of 3D Multicell Tumor Spheroids (2012)
AuthorsMcMahon, Kelly M.; Volpato, Milène; Chi, H.Y.; Musiwaro, P.; Poterlowicz, Krzysztof; Peng, Yonghong; Scally, Andy J.; Patterson, Laurence H.; Phillips, Roger M.; Sutton, Chris W.
 
TitleQuantitative proteomic profiling of matched normal and tumor breast tissues. (2010)
AuthorsSutton, Chris W.; Rustogi, Nitin; Gurkan, C.; Scally, Andy J.; Loizidou, M.A.; Hadjisavvas, A.; Kyriacou, K.