Skip to content

Dr Colin Seaton

Associate Professor

Faculty/Dept/School School of Chemistry and Bioscience
(Faculty of Life Sciences)
Telephone +441274 236155


Dr Colin Seaton received a first class BSc(Hons.) in Chemistry from the University of St. Andrews and a PhD in Chemistry froth University of Birmingham with a thesis entitled "Novel Methods of Crystal Structure Determination from Powder X-ray Diffraction Data".

His Research lies in the field of crystal engineering with key interests in polymorphism, creation of multi-component crystals, crystal growth and habit modification. His work brings together both experimental and computational approaches to these problems with a interest in the application of biologically inspired computational methods such as evolutionary algorithms. 

Teaching covers atomic and molecular structures, solid-state chemistry and computational chemistry. 


My research lies in the field of solid-state molecular chemistry, with the major focus on crystal engineering, the study of crystalline phases and controlling their formation. A key aim is the determination of the factors controlling the creation of crystal phases and using this understanding to design and create new materials. My work covers the development of both experimental (crystallisation processes, phase diagram construction, crystal structural determination by single crystal and powder diffraction methods) and computational methodologies (ab initio calculations, evolutionary algorithms) to gain the insight required.

Current topics of interest include work on understanding influence of experimental conditions on polymorphism through molecular modelling of solvent/solute interactions and molecular conformation, the influence of chemical and crystallographic factors on proton transfer in crystal materials and the creation of multi-component crystals (salts and co-crystals). Development of new computational methodologies to model additive/crystal interactions, molecule/molecule interactions and location of low energy molecular conformations.

Research collaborators
NameProf Ian Scowen
CompanyUniversity of Lincoln
ThemeCrystal Engineering
NameDr Tasmin Munshi
CompanyUniversity of Lincoln
ThemeCrystal Engineering


Year Module code Title Subject
CFS7009-BComputational Crystal Engineering
CFS7026-BSolid Analysis
CFS4022-BInorganic Chemistry 1
CFS4029-BInorganic Chemistry 1 (at distance)

Professional activities

  • 01-JAN-03: University of Birmingham - PhD
  • 01-JAN-99: University of St. Andrews - BSc (Hons)
  • 01-FEB-14: University of Bradford - Lecturer in Chemistry
  • 01-JUL-11: University of Limerick - Postdoctoral Research Fellow
  • 01-SEP-10: University of Manchester - Part-Time Postdoctoral Research Associate
  • 01-SEP-10: University of Bradford - Part-Time Teaching Associate
  • 01-JUN-10: University of Manchester - Postdoctoral Research Associate
  • 01-OCT-09: University of Bradford - Scientific Officer
  • 01-MAY-08: University of Manchester - Postdoctoral Research Associate
  • 01-JUL-03: University of Bradford - Postdoctoral Research Associate/Teaching Associate
  • Royal Society of Chemistry, Member (MRSC)
  • Institute of Chemical Engineers (IChemE), Affiliate Member
  • British Crystallographic Association, Member
  • British Association of Crystal Growth, Member
  • 01-JAN-12: BACG Young Scientist Award


Peer Reviewed Journal
TitleArtemisinin-acetylenedicarboxylic acid cocrystal: Screening, structure determination, and physicochemical property characterisation (2022)
AuthorsMakadia J.;Madu S.J.;Arroo R.;Seaton C.C.;Li M.
TitleConstruction of Ternary Phase Diagrams: Application of Quantitative NMR (2022)
AuthorsTelford R.;Obule W.;Seaton C.C.
JournalCrystal Growth and Design
TitleIndole-containing arene-ruthenium complexes with broad spectrum activity against antibiotic-resistant bacteria. (2022)
AuthorsNolan VC;Rafols L;Harrison J;Soldevila-Barreda JJ;Crosatti M;Garton NJ;Wegrzyn M;Timms DL;Seaton CC;Sendron H;Azmanova M;Barry NPE;Pitto-Barry A;Cox JAG;
JournalCurrent Research In Microbial Sciences
TitleIsostructurality of quinoxaline crystal phases: The interplay of weak hydrogen bonds and halogen bonding (2021)
AuthorsSaidykhan A.;Fenwick N.W.;Bowen R.D.;Telford R.;Seaton C.C.
TitleInfluence of Terminal Functionality on the Crystal Packing Behaviour and Cytotoxicity of Aromatic Oligoamides. (2021)
AuthorsDelfosse P;Seaton CC;Male L;Lord RM;Pike SJ;
TitleIntriguing High Z″ Cocrystals of Emtricitabine (2020)
AuthorsPalanisamy V.;Sanphui P.;Bolla G.;Narayan A.;Seaton C.C.;Vangala V.R.
JournalCrystal Growth and Design
TitleImproving Stability of Effervescent Products by Co-Crystal Formation: A Novel Application of Crystal Engineered Citric Acid (2020)
AuthorsPagire, SK; Seaton, CC; Paradkar, A
JournalCrystal Growth and Design
TitleStructural similarity in chiral-achiral multi-component crystals (2020)
AuthorsScowen I.J.;Alomar T.S.;Munshi T.;Seaton C.C.
TitleOrtho -Substituent effect on the crystal packing and solid state speciation of aromatic C -nitroso compounds (2020)
AuthorsPike S.J.;Heliot A.;Seaton C.C.
TitleContinuous Manufacturing of Cocrystals Using Solid State Shear Milling Technology (2018)
AuthorsKorde, S.; Pagire, S.; Pan, H.; Seaton, C.; Kelly, A.; Chen, Y.; Wang, Q.; Coates, P.; Paradkar, A.
JournalCrystal Growth and Design
TitleContinuous Manufacturing of Cocrystals Using Solid State Shear Milling Technology (2018)
AuthorsKorde, Sachin A.; Pagire, Sudhir K.; Pan, H.; Seaton, Colin C.; Kelly, Adrian L.; Chen, Y.; Wang, Q.; Coates, Philip D.; Paradkar, Anant R.
TitleStructural Motifs in Salts of Sulfathiazole: Implications for Design of Salt Forms in Pharmaceuticals APIs (2018)
AuthorsSeaton, Colin C.; Rayan, R.T.; Essifaow, E.A.A.; Nauha, E.; Munshi, Tasnim; Scowen, Ian J.
TitlePoly(acrylic acid) interpolymer complexes (2017)
AuthorsSwift, Thomas; Seaton, Colin C.; Rimmer, Stephen
JournalRSC Soft Matter
TitleStabilisation of metastable polymorphs: the case of paracetamol form III (2016)
AuthorsTelford, Richard; Seaton, Colin C.; Clout, A.; Buanz, A.B.M.; Gaisford, S.; Williams, G.R.; Prior, T.J.; Okoye, C.H.; Munshi, Tasnim; Scowen, Ian J.
TitleAn unusual Cu(II) complex of a Schiff-base ligand of 3-aminoquinoline with a hydronated pyridine unit: Synthesis, characterizations, and computational studies (2016)
AuthorsNayak S.;Pevec A.;Seaton C.;Gamez P.;Reedijk J.
TitleAre the Crystal Structures of Enantiopure and Racemic Mandelic Acids Determined by Kinetics or Thermodynamics? (2015)
AuthorsHylton, R.K.; Tizzard, G.J.; Threlfall, T.L.; Ellis, A.L.; Coles, S.J.; Seaton, Colin C.; Schulze, E.; Lorenz, H.; Seidel-Morgenstern, A.; Stein, M.; Price, S.L.
TitleInvestigation into solid and solution properties of quinizarin (2015)
AuthorsCheuk, D.; Svärd, M.; Seaton, Colin C.; McArdle, P.; Rasmuson, Å.C.
TitleThermal Behavior of Benzoic Acid/Isonicotinamide Binary Cocrystals (2015)
AuthorsBuanz, A.B.M.; Prior, T.J.; Burley, J.C.; Raimi-Abraham, B.T.; Telford, Richard; Hart, M.; Seaton, Colin C.; Davies, P.J.; Scowen, Ian J.; Gaisford, S.; Williams, G.R.
TitleProton location in acid⋯pyridine hydrogen bonds of multi-component crystals (2014)
AuthorsSeaton, Colin C.
TitleCreation of a ternary complex between a crown ether, 4-aminobenzoic acid and 3,5-dinitrobenzoic acid (2014)
AuthorsBoardman, N.D.; Munshi, Tasnim; Scowen, Ian J.; Seaton, Colin C.
TitleSolution-Mediated Polymorphic Transformation: Form II to Form III Piracetam in Organic Solvents (2014)
AuthorsMaher, A.; Croker, D.M.; Seaton, Colin C.; Rasmuson, Å.C.; Hodnett, B.K.
TitleInsight into the Mechanism of Formation of Channel Hydrates via Templating (2014)
AuthorsStokes, S.P.; Seaton, Colin C.; Eccles, K.S.; Maguire, A.R.; Lawrence, S.E.
TitleRacemic compound versus conglomerate: concerning the crystal chemistry of the triazoylketone, 1-(4-chlorophenyl)-4,4- dimethyl-2-(1H-1,2,4-triazol-1-yl)pentan-3-one (2014)
AuthorsDavey, R.J.; Sadiq, G.; Seaton, Colin C.; Pritchard, R.G.; Coquerel, G.; Rougeot, C.
TitleProton transfer and hydrogen bonding in the organic solid state: a combined XRD/XPS/ssNMR study of 17 organic acid–base complexes (2014)
AuthorsStevens, J.S.; Byard, S.J.; Seaton, Colin C.; Sadiq, G.; Davey, R.J.; Schroeder, S.L.M.
TitleInvestigating the dissolution of the metastable triclinic polymorph of carbamazepine using in situ microscopy (2014)
AuthorsO'Mahony, M.; Seaton, Colin C.; Croker, D.M.; Veesler, S.; Rasmuson, A.K.; Hodnett, B.K.
TitleComplete Colloidal Synthesis of Cu2SnSe3 Nanocrystals with Crystal Phase and Shape Control (2014)
AuthorsWang, J.; Liu, P.; Seaton, Colin C.; Ryan, K.M.
TitleNucleation in the p-toluenesulfonamide/triphenylphosphine oxide co-crystal system (2013)
AuthorsCroker D.;Davey R.;Rasmuson A.;Seaton C.
JournalCrystal Growth and Design
TitleMulti-component crystals of 4-phenylpyridine: challenging the boundaries between co-crystal and organic salt formation with insight into solid-state proton transfer (2013)
AuthorsSeaton, Colin C.; Munshi, Tasnim; Williams, Sara E.; Scowen, Ian J.
TitleTuning proton disorder in 3,5-dinitrobenzoic acid dimers: The effect of local environment (2013)
AuthorsJones A.;Blagden N.;McIntyre G.;Parkin A.;Seaton C.;Thomas L.;Wilson C.
JournalCrystal Growth and Design
TitleCreation of ternary multicomponent crystals by exploitation of charge-transfer interactions (2013)
AuthorsSeaton, Colin C.; Blagden, Nicholas; Munshi, Tasnim; Scowen, Ian J.
TitleSolution mediated phase transformations between co-crystals (2013)
AuthorsCroker D.;Davey R.;Rasmuson A.;Seaton C.
TitleInvestigation into the mechanism of solution-mediated transformation from FI to FIII carbamazepine: The role of dissolution and the interaction between polymorph surfaces (2013)
AuthorsO'Mahony M.;Seaton C.;Croker D.;Veesler S.;Rasmuson A.;Hodnett B.
JournalCrystal Growth and Design
TitleBuilding Multi-Component Crystals From Cations and Co-crystals: The Use of Chaperones (2013)
AuthorsBukenya S.;Munshi T.;Scowen I.;Skyner R.;Whitaker D.;Seaton C.
TitleThe isolation of a metastable conglomerate using a combined computational and controlled crystallization approach (2012)
AuthorsDavey R.;Sadiq G.;Back K.;Wilkinson L.;Seaton C.
JournalChemical Communications
TitleInvestigation of the solid-state polymorphic transformations of piracetam (2012)
AuthorsMaher A.;Seaton C.;Hudson S.;Croker D.;Rasmuson A.;Hodnett B.
JournalCrystal Growth and Design
TitleMaking benzamide cocrystals with benzoic acids: The influence of chemical structure (2011)
AuthorsSeaton C.;Parkin A.
JournalCrystal Growth and Design
TitleCreating carboxylic acid co-crystals: The application of Hammett substitution constants (2011)
AuthorsSeaton C.
TitleEpitaxial growth of polymorphic systems: The case of sulfathiazole (2011)
AuthorsMunroe A.;Croker D.;Hodnett B.;Seaton C.
TitleThe phase behavior and crystallization of 2-chloromandelic acid: The crystal structure of the pure enantiomer and the behavior of its metastable conglomerate (2011)
AuthorsLorenz H.;Von Langermann J.;Sadiq G.;Seaon C.;Davey R.;Seidel-Morgenstern A.
JournalCrystal Growth and Design
TitleCrystallography aided by atomic core-level binding energies: Proton transfer versus hydrogen bonding in organic crystal structures (2011)
AuthorsStevens J.;Byard S.;Seaton C.;Sadiq G.;Davey R.;Schroeder S.
JournalAngewandte Chemie - International Edition
TitleSolubility, metastable zone width measurement and crystal growth of the 1:1 benzoic acid/isonicotinamide cocrystal in solutions of variable stoichiometry (2010)
AuthorsBoyd S.;Back K.;Chadwick K.;Davey R.;Seaton C.
JournalJournal of Pharmaceutical Sciences
TitleDesigning acid/acid co-crystals through the application of hammett substituent constants (2010)
AuthorsSeaton C.;Chadwick K.;Sadiq G.;Guo K.;Davey R.
JournalCrystal Growth and Design
TitleCo-crystallization in the caffeine/maleic acid system: Lessons from phase equilibria (2010)
AuthorsGuo K.;Sadiq G.;Seaton C.;Davey R.;Yin Q.
JournalCrystal Growth and Design
TitleTuning proton behavior in a ternary molecular complex. (2010)
AuthorsThomas, L.H.; Blagden, Nicholas; Gutmann, M.J.; Kallay, A.A.; Parkin, A.; Seaton, Colin C.; Wilson, C.C.
TitleControlling the Formation of Benzoic Acid: Isonicotinamide Molecular Complexes. (2009)
AuthorsSeaton, Colin C.; Parkin, A.; Wilson, C.C.; Blagden, Nicholas
TitleFormation of a hybrid coordination-molecular complex. (2009)
AuthorsSeaton, Colin C.; Scowen, Ian J.; Blagden, Nicholas
TitleApplying hot-stage microscopy to co-crystal screening: A study of nicotinamide with seven active pharmaceutical ingredients. (2008)
AuthorsBerry, David J.; Seaton, Colin C.; Clegg, W.; Harrington, R.W.; Coles, S.J.; Horton, P.N.; Hursthouse, M.B.; Storey, Richard; Jones, W.; Friščić, T.; Blagden, Nicholas
TitleCurrent directions in co-crystal growth (2008)
AuthorsBlagden N.;Berry D.;Parkin A.;Javed H.;Ibrahim A.;Gavan P.;De Matos L.;Seaton C.
JournalNew Journal of Chemistry
TitleGrowth of an organic co-crystal upon a component subphase. (2008)
AuthorsSeaton, Colin C.; Parkin, A.; Wilson, C.C.; Blagden, Nicholas
TitleDesigning hydrogen bonds with temperature-dependent proton disorder: The effect of crystal environment (2007)
AuthorsParkin A.;Seaton C.;Blagden N.;Wilson C.
JournalCrystal Growth and Design
TitleMolecular versus crystal symmetry in tri-substituted triazine, benzene and isocyanurate derivatives (2006)
AuthorsChong S.;Seaton C.;Kariuki B.;Tremayne M.
JournalActa Crystallographica Section B: Structural Science
TitleOrdered Aggregation of Benzamide Crystals Induced using a "Motif Capper" Additive. (2005)
AuthorsBlagden, Nicholas; Song, M.; Davey, R.J.; Seton, L.; Seaton, Colin C.
TitleCharacterization of complicated new polymorphs of chlorothalonil by X-ray diffraction and computer crystal structure prediction (2004)
AuthorsTremayne M.;Grice L.;Pyatt J.;Seaton C.;Kariuki B.;Tsui H.;Price S.;Cherryman J.
JournalJournal of the American Chemical Society
TitleDifferential evolution: Crystal structure determination of a triclinic polymorph of adipamide from powder diffraction data (2002)
AuthorsSeaton C.;Tremayne M.
JournalChemical Communications
TitleStructures of three substituted arenesulfonamides from X-ray powder diffraction data using the differential evolution technique (2002)
AuthorsTremayne M.;Seaton C.;Glidewell C.
JournalActa Crystallographica Section B: Structural Science
TitleA combination of X-ray Single-crystal diffraction and Monte Carlo Structure Solution from X-ray Powder Diffraction Data in a structural investigation of 5-bromonicotinic acid and solvates thereof (2001)
AuthorsAakeroy CB; Beatty, AM; Tremayne, M; Rowe, DM; Seaton CC
JournalCrystal Growth and Design
Other Journal
TitleBuilding Up Co-crystals: Structural Motif Consistencies Across Families of Co-crystals (2021)
AuthorsColin C. Seaton