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researcher

Conor Meehan

Lecturer in Molecular Microbiology

Faculty/Dept/School School of Chemistry and Bioscience
(Faculty of Life Sciences)
Emailc.meehan2@bradford.ac.uk

Biography

Understanding how pathogens transmit between hosts and the underlying genomic mechanisms that confer resistance to drugs is crucial for reducing the incidence of infection and increasing the effectiveness of treatments.
Dr. Meehan's research focusses on the evolution and epidemiology of microbes, primarily pathogenic mycobacteria such as M. tuberculosis, M. ulcerans and M. leprae. His primary goal is to enhance incorporation of molecular techniques into clinical and public health settings for tracking drug resistance and pathogen transmission in high burden settings, with an emphasis on whole genome sequencing coupled with phylogenetics-based analyses.

Research

Mycobacterium tuberculosis transmission in high burden countries.
Incorporating whole genome sequencing into clinical decision making for the treatment of pathogens.
Improving bioinformatics techniques for pathogen detection and comparative genomics.

Professional activities

  • 03-MAR-14: Institute of Tropical Medicine - Research Fellow
  • 01-MAR-11: Dalhousie University - Postdoctoral Fellow
  • 03-JUN-19: University of Bradford - Lecturer in Molecular Microbiology
  • 01-JAN-11: NUI Galway, Ireland - Ph.D.
  • 01-JAN-07: Maynooth University, Ireland - B.Sc.

Publications

Peer Reviewed Journal
TitleWhole genome sequencing of Mycobacterium tuberculosis: current standards and open issues. (2019)
AuthorsMeehan CJ;Goig GA;Kohl TA;Verboven L;Dippenaar A;Ezewudo M;Farhat MR;Guthrie JL;Laukens K;Miotto P;Ofori-Anyinam B;Dreyer V;Supply P;Suresh A;Utpatel C;van Soolingen D;Zhou Y;Ashton PM;Brites D;Cabibbe AM;de Jong BC;de Vos M;Menardo F;Gagneux S;Gao Q;Heupink TH;Liu Q;Loiseau C;Rigouts L;Rodwell TC;Tagliani E;Walker TM;Warren RM;Zhao Y;Zignol M;Schito M;Gardy J;Cirillo DM;Niemann S;Comas I;Van Rie A;
JournalNature Reviews Microbiology
DOI10.1038/s41579-019-0214-5
 
TitleGWAS for quantitative resistance phenotypes in Mycobacterium tuberculosis reveals resistance genes and regulatory regions. (2019)
AuthorsFarhat MR;Freschi L;Calderon R;Ioerger T;Snyder M;Meehan CJ;de Jong B;Rigouts L;Sloutsky A;Kaur D;Sunyaev S;van Soolingen D;Shendure J;Sacchettini J;Murray M;
JournalNature Communications
DOI10.1038/s41467-019-10110-6
 
TitleMycobacterium ulcerans Population Genomics To Inform on the Spread of Buruli Ulcer across Central Africa. (2019)
AuthorsVandelannoote K;Phanzu DM;Kibadi K;Eddyani M;Meehan CJ;Jordaens K;Leirs H;Portaels F;Stinear TP;Harris SR;de Jong BC;
JournalMsphere
DOI10.1128/mSphere.00472-18
 
TitleStorage of Sputum in Cetylpyridinium Chloride, OMNIgene.SPUTUM, and Ethanol Is Compatible with Molecular Tuberculosis Diagnostic Testing. (2019)
AuthorsSanoussi CN;de Jong BC;Affolabi D;Meehan CJ;Odoun M;Rigouts L;
JournalJournal of Clinical Microbiology
DOI10.1128/JCM.00275-19
 
TitleSuperimposing incident sexually transmitted infections on HIV phylogram to investigate possible misclassification of men who have sex with men as heterosexuals in a cohort in Antwerp, Belgium. (2019)
AuthorsOsbak KK;Meehan CJ;G Ribas S;Heyndrickx L;Ariën KK;Tsoumanis A;Florence E;Esbroeck MV;Fransen K;Kenyon CR;
JournalInternational Journal of STD and AIDS
DOI10.1177/0956462418821752
 
TitleEthical Considerations for Movement Mapping to Identify Disease Transmission Hotspots. (2019)
Authorsde Jong BC;Gaye BM;Luyten J;van Buitenen B;Andre E;Meehan CJ;OSiochain C;Tomsu K;Urbain J;Grietens KP;Njue M;Pinxten W;Gehre F;Nyan O;Buve A;Roca A;Ravinetto R;Antonio M;
JournalEmerging Infectious Diseases
DOI10.3201/eid2507.181421
 
TitleIsoniazid resistance levels of Mycobacterium tuberculosis can largely be predicted by high-confidence resistance-conferring mutations. (2018)
AuthorsLempens P;Meehan CJ;Vandelannoote K;Fissette K;de Rijk P;Van Deun A;Rigouts L;de Jong BC;
JournalScientific Reports
DOI10.1038/s41598-018-21378-x
 
TitlePotential Application of Digitally Linked Tuberculosis Diagnostics for Real-Time Surveillance of Drug-Resistant Tuberculosis Transmission: Validation and Analysis of Test Results (2018)
AuthorsKamela Charmaine Ng;Conor Joseph Meehan;Gabriela Torrea;Leonie Goeminne;Maren Diels;Leen Rigouts;Bouke Catherine de Jong;Emmanuel Andre;
JournalJmir Medical Informatics
DOI10.2196/medinform.9309
 
TitleCandidate Treponema pallidum biomarkers uncovered in urine from individuals with syphilis using mass spectrometry. (2018)
AuthorsOsbak KK;Van Raemdonck GA;Dom M;Cameron CE;Meehan CJ;Deforce D;Ostade XV;Kenyon CR;Dhaenens M;
JournalFuture Microbiology
DOI10.2217/fmb-2018-0182
 
TitleComparative Genomics Shows That Mycobacterium ulcerans Migration and Expansion Preceded the Rise of Buruli Ulcer in Southeastern Australia. (2018)
AuthorsBuultjens AH;Vandelannoote K;Meehan CJ;Eddyani M;de Jong BC;Fyfe JAM;Globan M;Tobias NJ;Porter JL;Tomita T;Tay EL;Seemann T;Howden BP;Johnson PDR;Stinear TP;
JournalApplied And Environmental Microbiology
DOI10.1128/AEM.02612-17
 
TitleThe relationship between transmission time and clustering methods in Mycobacterium tuberculosis epidemiology (2018)
AuthorsMeehan CJ et al
JournalEbiomedicine
DOI10.1016/j.ebiom.2018.10.013
 
TitleXpert Ultra Can Unambiguously Identify Specific Rifampin Resistance-Conferring Mutations. (2018)
AuthorsNg KCS;van Deun A;Meehan CJ;Torrea G;Driesen M;Gabriels S;Rigouts L;Andre E;de Jong BC;
JournalJournal of Clinical Microbiology
DOI10.1128/JCM.00686-18
 
TitleThe Repetitive Element RLEP Is a Highly Specific Target for Detection of Mycobacterium leprae (2018)
AuthorsS. Braet;K. Vandelannoote;C. J. Meehan;A. N. Brum Fontes;E. Hasker;P. S. Rosa;N. Lucena Silva;L. Rigouts;P. N. Suffys;B. C. De Jong;
JournalJournal of Clinical Microbiology
DOI10.1128/JCM.01924-17
 
TitleWhole genome sequence of Mycobacterium kansasii isolates of the genotype 1 from Brazilian patients with pulmonary disease demonstrates considerable heterogeneity (2018)
AuthorsMachado E;Vasconcellos SEG;Cerdeira C;Gomes LL;Junqueira R;Carvalho LD;Ramos JP;Redner P;Campos CED;Caldas PCS;Gomes APCS;Goldenberg T;Montes FF;Mello FCQ;Mussi VO;Lasunskaia E;Soolingen DV;Miranda AB;Rigouts L;Jong BC;Meehan CJ;Catanho M;Suffys PN;
JournalMemorias do Instituto Oswaldo Cruz
DOI10.1590/0074-02760180085
 
TitleThe new phylogeny of the genus Mycobacterium: The old and the news. (2017)
AuthorsTortoli E;Fedrizzi T;Meehan CJ;Trovato A;Grottola A;Giacobazzi E;Serpini GF;Tagliazucchi S;Fabio A;Bettua C;Bertorelli R;Frascaro F;De Sanctis V;Pecorari M;Jousson O;Segata N;Cirillo DM;
JournalInfection, Genetics and Evolution
DOI10.1016/j.meegid.2017.10.013
 
TitleThe predominance of Ethiopian specific Mycobacterium tuberculosis families and minimal contribution of Mycobacterium bovis in tuberculous lymphadenitis patients in Southwest Ethiopia. (2017)
AuthorsTadesse M;Abebe G;Bekele A;Bezabih M;de Rijk P;Meehan CJ;de Jong BC;Rigouts L;
JournalInfection, Genetics and Evolution
DOI10.1016/j.meegid.2017.09.016
 
TitleSignificant under expression of the DosR regulon in M tuberculosis complex lineage 6 in sputum (2017)
AuthorsOfori Anyinam B;Dolganov G;Van T;Davis JL;Walter ND;Garcia BJ;Voskuil M;Fissette K;Diels M;Driesen M;Meehan CJ;Yeboah Manu D;Coscolla M;Gagneux S;Antonio M;Schoolnik G;Gehre F;de Jong BC
JournalTuberculosis (Edinburgh, Scotland)
DOI10.1016/j.tube.2017.03.001
 
TitleGenomic characterization of Nontuberculous Mycobacteria. (2017)
AuthorsFedrizzi T;Meehan CJ;Grottola A;Giacobazzi E;Fregni Serpini G;Tagliazucchi S;Fabio A;Bettua C;Bertorelli R;De Sanctis V;Rumpianesi F;Pecorari M;Jousson O;Tortoli E;Segata N;
JournalScientific Reports
DOI10.1038/srep45258
 
TitleUnexpected high prevalence of resistance-associated Rv0678 variants in MDR-TB patients without documented prior use of clofazimine or bedaquiline. (2017)
AuthorsVillellas C;Coeck N;Meehan CJ;Lounis N;de Jong B;Rigouts L;Andries K;
JournalJournal of Antimicrobial Chemotherapy
DOI10.1093/jac/dkw502
 
TitleMultiple Introductions and Recent Spread of the Emerging Human Pathogen Mycobacterium ulcerans across Africa. (2017)
AuthorsVandelannoote K;Meehan CJ;Eddyani M;Affolabi D;Phanzu DM;Eyangoh S;Jordaens K;Portaels F;Mangas K;Seemann T;Marsollier L;Marion E;Chauty A;Landier J;Fontanet A;Leirs H;Stinear TP;de Jong BC;
JournalGenome Biology and Evolution
DOI10.1093/gbe/evx003
 
TitleGenome-Wide SNP Analysis Reveals Distinct Origins of Trypanosoma evansi and Trypanosoma equiperdum. (2017)
AuthorsCuypers B;Van den Broeck F;Van Reet N;Meehan CJ;Cauchard J;Wilkes JM;Claes F;Goddeeris B;Birhanu H;Dujardin JC;Laukens K;Büscher P;Deborggraeve S;
JournalGenome Biology and Evolution
DOI10.1093/gbe/evx102
 
TitleApolipoprotein L1 Variant Associated with Increased Susceptibility to Trypanosome Infection. (2016)
AuthorsCuypers B;Lecordier L;Meehan CJ;Van den Broeck F;Imamura H;Büscher P;Dujardin JC;Laukens K;Schnaufer A;Dewar C;Lewis M;Balmer O;Azurago T;Kyei-Faried S;Ohene SA;Duah B;Homiah P;Mensah EK;Anleah F;Franco JR;Pays E;Deborggraeve S;
JournalmBio
DOI10.1128/mBio.02198-15
 
TitleDiagnosis of Bacterial Bloodstream Infections: A 16S Metagenomics Approach. (2016)
AuthorsDecuypere S;Meehan CJ;Van Puyvelde S;De Block T;Maltha J;Palpouguini L;Tahita M;Tinto H;Jacobs J;Deborggraeve S;
JournalPLoS Neglected Tropical Diseases
DOI10.1371/journal.pntd.0004470
 
TitleCharacterizing the Syphilis-Causing Treponema pallidum ssp. pallidum Proteome Using Complementary Mass Spectrometry. (2016)
AuthorsOsbak KK;Houston S;Lithgow KV;Meehan CJ;Strouhal M;Šmajs D;Cameron CE;Van Ostade X;Kenyon CR;Van Raemdonck GA;
JournalPLoS Neglected Tropical Diseases
DOI10.1371/journal.pntd.0004988
 
TitleWhole genome sequencing reveals mycobacterial microevolution among concurrent isolates from sputum and blood in HIV infected TB patients. (2016)
AuthorsSsengooba W;de Jong BC;Joloba ML;Cobelens FG;Meehan CJ;
JournalBMC Infectious Diseases
DOI10.1186/s12879-016-1737-2
 
TitleWhole genome sequencing to complement tuberculosis drug resistance surveys in Uganda. (2016)
AuthorsSsengooba W;Meehan CJ;Lukoye D;Kasule GW;Musisi K;Joloba ML;Cobelens FG;de Jong BC;
JournalInfection, Genetics and Evolution
DOI10.1016/j.meegid.2016.02.019
 
TitleCharacterizing the Diverse Mutational Pathways Associated with R5-Tropic Maraviroc Resistance: HIV-1 That Uses the Drug-Bound CCR5 Coreceptor. (2015)
AuthorsJiang X;Feyertag F;Meehan CJ;McCormack GP;Travers SA;Craig C;Westby M;Lewis M;Robertson DL;
JournalJournal of Virology
DOI10.1128/JVI.01384-15
 
TitleA Genomic Approach to Resolving Relapse versus Reinfection among Four Cases of Buruli Ulcer. (2015)
AuthorsEddyani M;Vandelannoote K;Meehan CJ;Bhuju S;Porter JL;Aguiar J;Seemann T;Jarek M;Singh M;Portaels F;Stinear TP;de Jong BC;
JournalPLoS Neglected Tropical Diseases
DOI10.1371/journal.pntd.0004158
 
TitleInteractions in the microbiome: communities of organisms and communities of genes. (2014)
AuthorsBoon E;Meehan CJ;Whidden C;Wong DH;Langille MG;Beiko RG;
JournalFEMS Microbiology Reviews
DOI10.1111/1574-6976.12035
 
TitleMicrobial shifts in the aging mouse gut (2014)
AuthorsLangille M.;Meehan C.;Koenig J.;Dhanani A.;Rose R.;Howlett S.;Beiko R.
JournalMicrobiome
DOI10.1186/s40168-014-0050-9
 
TitleA phylogenomic view of ecological specialization in the Lachnospiraceae, a family of digestive tract-associated bacteria. (2014)
AuthorsMeehan CJ;Beiko RG;
JournalGenome Biology and Evolution
DOI10.1093/gbe/evu050
 
TitleBeing Aquifex aeolicus: Untangling a hyperthermophile's checkered past. (2013)
AuthorsEveleigh RJ;Meehan CJ;Archibald JM;Beiko RG;
JournalGenome Biology and Evolution
DOI10.1093/gbe/evt195
 
TitleLateral gene transfer of an ABC transporter complex between major constituents of the human gut microbiome. (2012)
AuthorsMeehan CJ;Beiko RG;
JournalBMC Microbiology
DOI10.1186/1471-2180-12-248
 
TitleThe evolution of the class A scavenger receptors. (2012)
AuthorsWhelan FJ;Meehan CJ;Golding GB;McConkey BJ;Bowdish DM;
JournalBMC Evolutionary Biology
DOI10.1186/1471-2148-12-227
 
TitleEmergence, dominance, and possible decline of CXCR4 chemokine receptor usage during the course of HIV infection. (2010)
AuthorsMeehan CJ;Hedge JA;Robertson DL;McCormack GP;Travers SA;
JournalJournal of Medical Virology
DOI10.1002/jmv.21922