Professor Anne Graham
Professor of Biochemistry
| Faculty/Dept/School |
School of Chemistry and Bioscience (Faculty of Life Sciences) |
|---|---|
| a.graham@bradford.ac.uk | |
| Telephone | +441274 233570 |
Biography
Study of human endothelial cell genetic and functional responses in health and inflammatory disease (atherosclerosis, diabetes, cancer). These cells lining the blood vessels are master regulators of acute inflammation in health and chronic inflammation in disease. Low grade chronic inflammation at the blood vessel wall results in lesion formation and narrowing of the vessels (atherosclerotic plaques). Therefore cardiovascular disease and diabetes are key disorders where endothelial cells are dysfunctional. Skin disease such as psoriasis also have an important inflammatory vascular component. Intra-cellular signalling pathways important in endothelial cell proliferation, migration and apoptosis are currently under study in the Graham laboratory.
Outside the lab, interventions which reduce cardiovascular complications in diabetes, through development of patient self management is an active area of research, in collaboration with pharmacists and researchers in the School of Pharmacy and Medical Sciences
Research
Endothelial cell function in health and disease (atherosclerosis, diabetes, kidney disease, psoriasis) Mechanisms of compromised wound healing in chronic disease (diabetes). Epigenetic regulation of vascular cell function in diabetes. Mechanisms of angiogenesis relevant to cardiovascular disease and diabetes.
| Research collaborators | |
|---|---|
| Name | Professor Jun Tao |
| Company | First Affiliated Hospital, Sun Yat-Sen University |
| Country | CHINA |
| Type | E |
| Role | Common interest in hypertension and cell signalling |
| Theme | hypertension and atherosclerosis |
| Description | Development of projects for exchanges between groups |
Professional activities
- - N/A
Publications
| Peer Reviewed Journal | |
|---|---|
| Title | Platelet microparticle delivered microRNA-Let-7a promotes the angiogenic switch (2018) |
| Authors | Anene, Chinedu; Graham, Anne M.; Boyne, James R.; Roberts, Wayne |
| Title | IL-36y is a strong inducer of IL-23 in psoriatic cells and activates angiogenesis (2018) |
| Authors | Bridgewood, Charlie; Fearnley, G.W.; Berekmeri, A.; Laws, P.; Macleod, T.; Ponnambalam, S.; Stacey, M.; Graham, Anne M.; Wittman, Miriam |
| Title | IL-36γ is a strong inducer of IL-23 in psoriatic cells and activates angiogenesis (2018) |
| Authors | Bridgewood C.;Fearnley G.;Berekmeri A.;Laws P.;Macleod T.;Ponnambalam S.;Stacey M.;Graham A.;Wittmann M. |
| Journal | Frontiers in Immunology |
| DOI | 10.3389/fimmu.2018.00200 |
| Title | IL-36γ has proinflammatory effects on human endothelial cells (2017) |
| Authors | Bridgewood, Charlie; Stacey, M.; Alase, Adewonuola A.; Lagos, D.; Graham, Anne M.; Wittmann, Miriam |
| Title | The Role of Maternal Gestational Diabetes in Inducing Fetal Endothelial Dysfunction (2015) |
| Authors | Sultan, S.A.; Liu, Wanting; Peng, Yonghong; Roberts, Wayne; Whitelaw, D.C.; Graham, Anne M. |
| Title | Reed-Sternberg cell-derived lymphotoxin-a activates endothelial cells to enhance T-cell recruitment in classical Hodgkin lymphoma (2014) |
| Authors | Fhu, C.W.; Graham, Anne M.; Yap, C.T.; Al-Salam, S.; Castella, A.; Chong, S.M.; Lim, Yaw-Chyn |
| Title | An in vitro model of warm hypoxia-reoxygenation injury in human liver endothelial cells (2012) |
| Authors | Banga N.;Prasad K.;Burn J.;Homer-Vanniasinkam S.;Graham A. |
| Journal | Journal of Surgical Research |
| DOI | 10.1016/j.jss.2011.12.036 |
| Title | Chronic homocysteine exposure upregulates endothelial adhesion molecules and mediates leukocyte: Endothelial cell interactions under flow conditions (2011) |
| Authors | Alkhoury K.;Parkin S.;Homer-Vanniasinkam S.;Graham A. |
| Journal | European journal of vascular and endovascular surgery : the official journal of the European Society for Vascular Surgery |
| DOI | 10.1016/j.ejvs.2010.11.012 |
| Title | The Impact of Different Concentrations of Sodium Tetradecyl Sulphate and Initial Balloon Denudation on Endothelial Cell Loss and Tunica Media Injury in a Model of Foam Sclerotherapy (2010) |
| Authors | Ikponmwosa A.;Abbott C.;Graham A.;Homer-Vanniasinkam S.;Gough M. |
| Journal | European journal of vascular and endovascular surgery : the official journal of the European Society for Vascular Surgery |
| DOI | 10.1016/j.ejvs.2009.12.025 |
| Title | Pathogenic mechanisms in varicose vein disease: The role of hypoxia and inflammation (2010) |
| Authors | Hossein Ghaderian S.;Lindsey N.;Graham A.;Homer-Vanniasinkam S.;Najar R. |
| Journal | Pathology |
| DOI | 10.3109/00313025.2010.493865 |
| Title | Simvastatin alters human endothelial cell adhesion molecule expression and inhibits leukocyte adhesion under flow (2008) |
| Authors | Eccles K.;Sowden H.;Porter K.;Parkin S.;Homer-Vanniasinkam S.;Graham A. |
| Journal | Atherosclerosis |
| DOI | 10.1016/j.atherosclerosis.2007.12.018 |
| Title | Globular adiponectin induces platelet activation through the collagen receptor GPVI-Fc receptor γ chain complex (2008) |
| Authors | Riba R.;Hughes C.;Graham A.;Watson S.;Naseem K. |
| Journal | Journal of Thrombosis and Haemostasis |
| DOI | 10.1111/j.1538-7836.2008.02982.x |
| Title | cGMP-independent inhibition of integrin αIIbβ3-mediated platelet adhesion and outside-in signalling by nitric oxide (2007) |
| Authors | Oberprieler N.;Roberts W.;Graham A.;Homer-Vanniasinkam S.;Naseem K. |
| Journal | FEBS Letters |
| DOI | 10.1016/j.febslet.2007.02.072 |
| Title | Inhibition of ADP-induced platelet adhesion to immobilised fibrinogen by nitric oxide: evidence for cGMP-independent mechanisms. (2007) |
| Authors | Graham, Anne M.; Homer-Vanniasinkam, Shervanthi; Naseem, Khalid M.; Oberprieler, Nikolaus G.; Roberts, Wayne |
| Title | cGMP-independent inhibition of integrin alphaIIbbeta3- mediated platelet adhesion and outside-in signalling by nitric oxide (2007) |
| Authors | Graham, Anne M.; Naseem, Khalid M.; Oberprieler, Nikolaus G.; Riba, Rocio; Roberts, Wayne; Homer-Vanniasinkam, Shervanthi |
| Title | Toll-like receptor-mediated responses of primary intestinal epithelial cells during the development of colitis (2005) |
| Authors | Singh J.;Cruickshank S.;Newton D.;Wakenshaw L.;Graham A.;Lan J.;Lodge J.;Felsburg P.;Carding S. |
| Journal | American Journal of Physiology - Gastrointestinal and Liver Physiology |
| DOI | 10.1152/ajpgi.00377.2004 |
| Title | The effects of margination and red cell augmented platelet diffusivity on platelet adhesion in complex flow (2004) |
| Authors | Jordan A.;David T.;Homer-Vanniasinkam S.;Graham A.;Walker P. |
| Journal | Biorheology |
| Title | Toll-like receptor-mediated responses of primary intestinal epithelial cells during the development of colitis (2004) |
| Authors | Singh, J.C.I.; Cruickshank, S.M.; Newton, D.J.; Wakenshaw, L.; Graham, Anne M.; Lan, J.; Lodge, J.P.A.; Felsburg, P.J.; Carding, S.R. |
| Title | Nuclear factor kappa B is involved in lipopolysaccharide- stimulated induction of interferon regulatory factor-1 and GAS/GAF DNA-binding in human umbilical vein endothelial cells. (2001) |
| Authors | Graham, Anne M.; Bryant, C.; Liu, L.; Plevin, R.; Andrew, P.; Mackenzie, C. |
| Title | Human monoclonal anti-endothelial cell IgG-derived from a systemic lupus erythematosus patient binds and activates human endotheliium in vitro. (2001) |
| Authors | Yazici, Zihni A.; Raschi, E.; Patel, Anjana; Testoni, C.; Borghi, M.O.; Graham, Anne M.; Meroni, P.L.; Lindsey, Nigel J. |
| Title | Human monoclonal anti-endothelial cell IgG-derived from a systemic lupus erythematosus patient binds and activates human endothelium in vitro (2001) |
| Authors | Yazici Z.;Raschi E.;Patel A.;Testoni C.;Borghi M.;Graham A.;Meroni P.;Lindsey N. |
| Journal | International Immunology |
| DOI | 10.1093/intimm/13.3.349 |
| Title | α-Melanocyte-stimulating hormone modulates nitric oxide production in melanocytes (2000) |
| Authors | Tsatmali M.;Graham A.;Szatkowski D.;Ancans J.;Manning P.;McNeil C.;Graham A.;Thody A. |
| Journal | Journal of Investigative Dermatology |
| DOI | 10.1046/j.1523-1747.2000.00879.x |