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researcher

Anne Graham

Professor of Biochemistry

Faculty/Dept/School School of Chemistry and Bioscience
(Faculty of Life Sciences)
Emaila.graham@bradford.ac.uk
Telephone +441274 233570

Biography

Study of human endothelial cell genetic and functional responses in health and inflammatory disease (atherosclerosis, diabetes, cancer). These cells lining the blood vessels play a key role in acute inflammation in health and chronic inflammation in disease. Low grade chronic inflammation at the blood vessel wall results in lesion formation and narrowing of the vessels (atherosclerotic plaques). Therefore cardiovascular disease and diabetes are key disorders where endothelial cells are dysfunctional. Skin disease such as psoriasis also have a vascular component. Endothelial cells also have the ability to sprout and develop new blood vessels (angiogenesis), which is physiologically important but can stimulate metastasis in cancer. Intra-cellular signalling pathways important in endothelial cell proliferation, migration and apoptosis are currently under study in the Graham laboratory

Research

Endothelial cell function in health and disease (atherosclerosis, diabetes, kidney disease, psoriasis) Mechanisms of compromised wound healing in chronic disease (diabetes). Epigenetic regulation of vascular cell function in diabetes. Mechanisms of angiogenesis relevant to cardiovascular disease and diabetes. 

 
Research collaborators
NameProfessor Jun Tao
CompanyFirst Affiliated Hospital, Sun Yat-Sen University
CountryCHINA
TypeE
RoleCommon interest in hypertension and cell signalling
Themehypertension and atherosclerosis
DescriptionDevelopment of projects for exchanges between groups
 

Professional activities

  • - N/A

Publications

Peer Reviewed Journal
TitlePlatelet microparticle delivered microRNA-Let-7a promotes the angiogenic switch (2018)
AuthorsAnene, Chinedu; Graham, Anne M.; Boyne, James R.; Roberts, Wayne
 
TitleIL-36y is a strong inducer of IL-23 in psoriatic cells and activates angiogenesis (2018)
AuthorsBridgewood, Charlie; Fearnley, G.W.; Berekmeri, A.; Laws, P.; Macleod, T.; Ponnambalam, S.; Stacey, M.; Graham, Anne M.; Wittman, Miriam
 
TitleIL-36γ is a strong inducer of IL-23 in psoriatic cells and activates angiogenesis (2018)
AuthorsBridgewood C.;Fearnley G.;Berekmeri A.;Laws P.;Macleod T.;Ponnambalam S.;Stacey M.;Graham A.;Wittmann M.
JournalFrontiers in Immunology
DOI10.3389/fimmu.2018.00200
 
TitleIL-36γ has proinflammatory effects on human endothelial cells (2017)
AuthorsBridgewood, Charlie; Stacey, M.; Alase, Adewonuola A.; Lagos, D.; Graham, Anne M.; Wittmann, Miriam
 
TitleThe Role of Maternal Gestational Diabetes in Inducing Fetal Endothelial Dysfunction (2015)
AuthorsSultan, S.A.; Liu, Wanting; Peng, Yonghong; Roberts, Wayne; Whitelaw, D.C.; Graham, Anne M.
 
TitleReed-Sternberg cell-derived lymphotoxin-a activates endothelial cells to enhance T-cell recruitment in classical Hodgkin lymphoma (2014)
AuthorsFhu, C.W.; Graham, Anne M.; Yap, C.T.; Al-Salam, S.; Castella, A.; Chong, S.M.; Lim, Yaw-Chyn
 
TitleAn in vitro model of warm hypoxia-reoxygenation injury in human liver endothelial cells (2012)
AuthorsBanga N.;Prasad K.;Burn J.;Homer-Vanniasinkam S.;Graham A.
JournalJournal of Surgical Research
DOI10.1016/j.jss.2011.12.036
 
TitleChronic homocysteine exposure upregulates endothelial adhesion molecules and mediates leukocyte: Endothelial cell interactions under flow conditions (2011)
AuthorsAlkhoury K.;Parkin S.;Homer-Vanniasinkam S.;Graham A.
JournalEuropean journal of vascular and endovascular surgery : the official journal of the European Society for Vascular Surgery
DOI10.1016/j.ejvs.2010.11.012
 
TitleThe Impact of Different Concentrations of Sodium Tetradecyl Sulphate and Initial Balloon Denudation on Endothelial Cell Loss and Tunica Media Injury in a Model of Foam Sclerotherapy (2010)
AuthorsIkponmwosa A.;Abbott C.;Graham A.;Homer-Vanniasinkam S.;Gough M.
JournalEuropean journal of vascular and endovascular surgery : the official journal of the European Society for Vascular Surgery
DOI10.1016/j.ejvs.2009.12.025
 
TitlePathogenic mechanisms in varicose vein disease: The role of hypoxia and inflammation (2010)
AuthorsHossein Ghaderian S.;Lindsey N.;Graham A.;Homer-Vanniasinkam S.;Najar R.
JournalPathology
DOI10.3109/00313025.2010.493865
 
TitleSimvastatin alters human endothelial cell adhesion molecule expression and inhibits leukocyte adhesion under flow (2008)
AuthorsEccles K.;Sowden H.;Porter K.;Parkin S.;Homer-Vanniasinkam S.;Graham A.
JournalAtherosclerosis
DOI10.1016/j.atherosclerosis.2007.12.018
 
TitleGlobular adiponectin induces platelet activation through the collagen receptor GPVI-Fc receptor γ chain complex (2008)
AuthorsRiba R.;Hughes C.;Graham A.;Watson S.;Naseem K.
JournalJournal of Thrombosis and Haemostasis
DOI10.1111/j.1538-7836.2008.02982.x
 
TitlecGMP-independent inhibition of integrin αIIbβ3-mediated platelet adhesion and outside-in signalling by nitric oxide (2007)
AuthorsOberprieler N.;Roberts W.;Graham A.;Homer-Vanniasinkam S.;Naseem K.
JournalFEBS Letters
DOI10.1016/j.febslet.2007.02.072
 
TitleInhibition of ADP-induced platelet adhesion to immobilised fibrinogen by nitric oxide: evidence for cGMP-independent mechanisms. (2007)
AuthorsGraham, Anne M.; Homer-Vanniasinkam, Shervanthi; Naseem, Khalid M.; Oberprieler, Nikolaus G.; Roberts, Wayne
 
TitlecGMP-independent inhibition of integrin alphaIIbbeta3- mediated platelet adhesion and outside-in signalling by nitric oxide (2007)
AuthorsGraham, Anne M.; Naseem, Khalid M.; Oberprieler, Nikolaus G.; Riba, Rocio; Roberts, Wayne; Homer-Vanniasinkam, Shervanthi
 
TitleToll-like receptor-mediated responses of primary intestinal epithelial cells during the development of colitis (2005)
AuthorsSingh J.;Cruickshank S.;Newton D.;Wakenshaw L.;Graham A.;Lan J.;Lodge J.;Felsburg P.;Carding S.
JournalAmerican Journal of Physiology - Gastrointestinal and Liver Physiology
DOI10.1152/ajpgi.00377.2004
 
TitleThe effects of margination and red cell augmented platelet diffusivity on platelet adhesion in complex flow (2004)
AuthorsJordan A.;David T.;Homer-Vanniasinkam S.;Graham A.;Walker P.
JournalBiorheology
 
TitleToll-like receptor-mediated responses of primary intestinal epithelial cells during the development of colitis (2004)
AuthorsSingh, J.C.I.; Cruickshank, S.M.; Newton, D.J.; Wakenshaw, L.; Graham, Anne M.; Lan, J.; Lodge, J.P.A.; Felsburg, P.J.; Carding, S.R.
 
TitleNuclear factor kappa B is involved in lipopolysaccharide- stimulated induction of interferon regulatory factor-1 and GAS/GAF DNA-binding in human umbilical vein endothelial cells. (2001)
AuthorsGraham, Anne M.; Bryant, C.; Liu, L.; Plevin, R.; Andrew, P.; Mackenzie, C.
 
TitleHuman monoclonal anti-endothelial cell IgG-derived from a systemic lupus erythematosus patient binds and activates human endotheliium in vitro. (2001)
AuthorsYazici, Zihni A.; Raschi, E.; Patel, Anjana; Testoni, C.; Borghi, M.O.; Graham, Anne M.; Meroni, P.L.; Lindsey, Nigel J.
 
TitleHuman monoclonal anti-endothelial cell IgG-derived from a systemic lupus erythematosus patient binds and activates human endothelium in vitro (2001)
AuthorsYazici Z.;Raschi E.;Patel A.;Testoni C.;Borghi M.;Graham A.;Meroni P.;Lindsey N.
JournalInternational Immunology
DOI10.1093/intimm/13.3.349
 
Titleα-Melanocyte-stimulating hormone modulates nitric oxide production in melanocytes (2000)
AuthorsTsatmali M.;Graham A.;Szatkowski D.;Ancans J.;Manning P.;McNeil C.;Graham A.;Thody A.
JournalJournal of Investigative Dermatology
DOI10.1046/j.1523-1747.2000.00879.x