Professor Anne Graham
Head of School of Chemistry & Bioscience
| Faculty/Dept/School |
School of Chemistry and Bioscience (Faculty of Life Sciences) |
|---|---|
| a.graham@bradford.ac.uk | |
| Telephone | +441274 233570 |
Biography
Study of human endothelial cell genetic and functional responses in health and inflammatory disease (atherosclerosis, diabetes, cancer). These cells lining the blood vessels are master regulators of acute inflammation in health and chronic inflammation in disease. Low grade chronic inflammation at the blood vessel wall results in lesion formation and narrowing of the vessels (atherosclerotic plaques). Therefore cardiovascular disease and diabetes are key disorders where endothelial cells are dysfunctional. Skin disease such as psoriasis also have an important inflammatory vascular component. Intra-cellular signalling pathways important in endothelial cell proliferation, migration and apoptosis are currently under study in the Graham laboratory.
Outside the lab, interventions which reduce cardiovascular complications in diabetes, through development of patient self management is an active area of research, in collaboration with pharmacists and researchers in the School of Pharmacy and Medical Sciences and collaborators in Bangladesh (Professor Fatema Ashraf, Surawahardy Hospital and Medical College
Research
Endothelial cell function in health and disease (atherosclerosis, diabetes, kidney disease, psoriasis) Mechanisms of compromised wound healing in chronic disease (diabetes). Epigenetic regulation of vascular cell function in diabetes. Mechanisms of angiogenesis relevant to cardiovascular disease and diabetes.
| Research collaborators | |
|---|---|
| Name | Professor Jun Tao |
| Company | First Affiliated Hospital, Sun Yat-Sen University |
| Country | CHINA |
| Type | E |
| Role | Common interest in hypertension and cell signalling |
| Theme | hypertension and atherosclerosis |
| Description | Development of projects for exchanges between groups |
Teaching
Teaching highlights
We run engaging workshops where groups of final year students apply knowledge about MAP kinase signalling pathways from lectures to drug development for anti-cancer agents.
Second year Clinical and Analytical Biochemistry workshops allow students to diagnose medical conditions based on clinical test results. Small group sessions build confidence and help develop understanding oc complex disease conditions.
Professional activities
- 01-JAN-12: University of Bradford - PGCert
- 01-JAN-07: HEA - Fellow Higher Education Academy
- 01-JAN-89: University of Glasgow - PhD
- 01-JAN-86: Strathclyde University - Bsc (Hons)
- 01-JAN-13: University of Bradford - Acting Dean of Graduate Studies
- 01-JAN-15: University of Bradford - Chair Director PGR Forum
- 01-JAN-11: University of Bradford - Member Research Degrees Committee
- 01-JAN-15: University of Bradford - Member Ethics Committee
- 01-JAN-94: British Heart Foundation -
- 01-JAN-91: Wellcome Trust - Postdoctoral researcher
- 08-JAN-18: NC3Rs, Studentship Grant Panel member
- 01-JAN-15: Heart Research UK, Translational Grant Panel member
- 01-FEB-16: Institute of Biomedical Science , Fellow
- British Inflammation Research Association, Committee member
- 01-AUG-14: Institute of Biomedical Science, Fellow
- University Research & Knowledge Transfer Research Strategy Committee,
- Senate, Represent Faculty of Life Sciences Research & Knowledge Transfer interests
- Research & Knowledge Transfer
- Chair Faculty Research KT Strategy committee
- Chair Faculty PGR committee
- Programme & Module Management: Deputy Chair University Research & Knowledge Transfer Strategy Committee
- Other: Option Convenor Medical Biochemistry Option on BSc Biomedical Science (UoB and Singapore)
- Programme & Module Management: Member of Faculty Executive committee
- Academic Leadership: Chair of Faculty Research & Knowledge Transfer Committee
- Academic Leadership: Chair of Faculty PGR Committee
- Co-lead of a monthly public engagement with science meeting, in partnership with the National Science & Media Museum and Theatre in the Mill. Bringing scientists and refreshments to a local venue.
- Fellow/Member/Chair/Role Model: Role Model for Aurora Programme - Leadership Foundation (2015/16 & 2016/17) Member of editorial board of Journal of Inflammation (2001- ) Researcher Development Framework Champion, Vitae (2012- ) UK Council for Graduate Education “Structures” working group member (2014- ) British Inflammation Research Association committee (2001- ) Fellow Institute of Biomedical Sciences (2014- ) Fellow Higher Education Academy (2007- ) Member of British Pharmacology Society (1992- ) Member of Biochemical Society (1992- ) Member of British Society for Immunology (1999- ) Grant review panel Chair for Heart Research UK (2009)
Publications
| Peer Reviewed Journal | |
|---|---|
| Title | IL-36γ is a strong inducer of IL-23 in psoriatic cells and activates angiogenesis (2018) |
| Authors | Bridgewood C.;Fearnley G.;Berekmeri A.;Laws P.;Macleod T.;Ponnambalam S.;Stacey M.;Graham A.;Wittmann M. |
| Journal | Frontiers in Immunology |
| DOI | 10.3389/fimmu.2018.00200 |
| Title | Platelet microparticle delivered microRNA-Let-7a promotes the angiogenic switch (2018) |
| Authors | Anene, Chinedu; Graham, Anne M.; Boyne, James R.; Roberts, Wayne |
| Title | IL-36y is a strong inducer of IL-23 in psoriatic cells and activates angiogenesis (2018) |
| Authors | Bridgewood, Charlie; Fearnley, G.W.; Berekmeri, A.; Laws, P.; Macleod, T.; Ponnambalam, S.; Stacey, M.; Graham, Anne M.; Wittman, Miriam |
| Title | IL-36γ has proinflammatory effects on human endothelial cells (2017) |
| Authors | Bridgewood, Charlie; Stacey, M.; Alase, Adewonuola A.; Lagos, D.; Graham, Anne M.; Wittmann, Miriam |
| Title | The Role of Maternal Gestational Diabetes in Inducing Fetal Endothelial Dysfunction (2015) |
| Authors | Sultan, S.A.; Liu, Wanting; Peng, Yonghong; Roberts, Wayne; Whitelaw, D.C.; Graham, Anne M. |
| Title | Reed-Sternberg cell-derived lymphotoxin-a activates endothelial cells to enhance T-cell recruitment in classical Hodgkin lymphoma (2014) |
| Authors | Fhu, C.W.; Graham, Anne M.; Yap, C.T.; Al-Salam, S.; Castella, A.; Chong, S.M.; Lim, Yaw-Chyn |
| Title | An in vitro model of warm hypoxia-reoxygenation injury in human liver endothelial cells (2012) |
| Authors | Banga N.;Prasad K.;Burn J.;Homer-Vanniasinkam S.;Graham A. |
| Journal | Journal of Surgical Research |
| DOI | 10.1016/j.jss.2011.12.036 |
| Title | Chronic homocysteine exposure upregulates endothelial adhesion molecules and mediates leukocyte: Endothelial cell interactions under flow conditions (2011) |
| Authors | Alkhoury K.;Parkin S.;Homer-Vanniasinkam S.;Graham A. |
| Journal | European journal of vascular and endovascular surgery : the official journal of the European Society for Vascular Surgery |
| DOI | 10.1016/j.ejvs.2010.11.012 |
| Title | Pathogenic mechanisms in varicose vein disease: The role of hypoxia and inflammation (2010) |
| Authors | Hossein Ghaderian S.;Lindsey N.;Graham A.;Homer-Vanniasinkam S.;Najar R. |
| Journal | Pathology |
| DOI | 10.3109/00313025.2010.493865 |
| Title | The Impact of Different Concentrations of Sodium Tetradecyl Sulphate and Initial Balloon Denudation on Endothelial Cell Loss and Tunica Media Injury in a Model of Foam Sclerotherapy (2010) |
| Authors | Ikponmwosa A.;Abbott C.;Graham A.;Homer-Vanniasinkam S.;Gough M. |
| Journal | European journal of vascular and endovascular surgery : the official journal of the European Society for Vascular Surgery |
| DOI | 10.1016/j.ejvs.2009.12.025 |
| Title | Globular adiponectin induces platelet activation through the collagen receptor GPVI-Fc receptor γ chain complex (2008) |
| Authors | Riba R.;Hughes C.;Graham A.;Watson S.;Naseem K. |
| Journal | Journal of Thrombosis and Haemostasis |
| DOI | 10.1111/j.1538-7836.2008.02982.x |
| Title | Simvastatin alters human endothelial cell adhesion molecule expression and inhibits leukocyte adhesion under flow (2008) |
| Authors | Eccles K.;Sowden H.;Porter K.;Parkin S.;Homer-Vanniasinkam S.;Graham A. |
| Journal | Atherosclerosis |
| DOI | 10.1016/j.atherosclerosis.2007.12.018 |
| Title | cGMP-independent inhibition of integrin alphaIIbbeta3- mediated platelet adhesion and outside-in signalling by nitric oxide (2007) |
| Authors | Graham, Anne M.; Naseem, Khalid M.; Oberprieler, Nikolaus G.; Riba, Rocio; Roberts, Wayne; Homer-Vanniasinkam, Shervanthi |
| Title | cGMP-independent inhibition of integrin αIIbβ3-mediated platelet adhesion and outside-in signalling by nitric oxide (2007) |
| Authors | Oberprieler N.;Roberts W.;Graham A.;Homer-Vanniasinkam S.;Naseem K. |
| Journal | FEBS Letters |
| DOI | 10.1016/j.febslet.2007.02.072 |
| Title | Inhibition of ADP-induced platelet adhesion to immobilised fibrinogen by nitric oxide: evidence for cGMP-independent mechanisms. (2007) |
| Authors | Graham, Anne M.; Homer-Vanniasinkam, Shervanthi; Naseem, Khalid M.; Oberprieler, Nikolaus G.; Roberts, Wayne |
| Title | Toll-like receptor-mediated responses of primary intestinal epithelial cells during the development of colitis (2005) |
| Authors | Singh J.;Cruickshank S.;Newton D.;Wakenshaw L.;Graham A.;Lan J.;Lodge J.;Felsburg P.;Carding S. |
| Journal | American Journal of Physiology - Gastrointestinal and Liver Physiology |
| DOI | 10.1152/ajpgi.00377.2004 |
| Title | The effects of margination and red cell augmented platelet diffusivity on platelet adhesion in complex flow (2004) |
| Authors | Jordan A.;David T.;Homer-Vanniasinkam S.;Graham A.;Walker P. |
| Journal | Biorheology |
| Title | Toll-like receptor-mediated responses of primary intestinal epithelial cells during the development of colitis (2004) |
| Authors | Singh, J.C.I.; Cruickshank, S.M.; Newton, D.J.; Wakenshaw, L.; Graham, Anne M.; Lan, J.; Lodge, J.P.A.; Felsburg, P.J.; Carding, S.R. |
| Title | Nuclear factor kappa B is involved in lipopolysaccharide- stimulated induction of interferon regulatory factor-1 and GAS/GAF DNA-binding in human umbilical vein endothelial cells. (2001) |
| Authors | Graham, Anne M.; Bryant, C.; Liu, L.; Plevin, R.; Andrew, P.; Mackenzie, C. |
| Title | Human monoclonal anti-endothelial cell IgG-derived from a systemic lupus erythematosus patient binds and activates human endothelium in vitro (2001) |
| Authors | Yazici Z.;Raschi E.;Patel A.;Testoni C.;Borghi M.;Graham A.;Meroni P.;Lindsey N. |
| Journal | International Immunology |
| DOI | 10.1093/intimm/13.3.349 |
| Title | Human monoclonal anti-endothelial cell IgG-derived from a systemic lupus erythematosus patient binds and activates human endotheliium in vitro. (2001) |
| Authors | Yazici, Zihni A.; Raschi, E.; Patel, Anjana; Testoni, C.; Borghi, M.O.; Graham, Anne M.; Meroni, P.L.; Lindsey, Nigel J. |
| Title | α-Melanocyte-stimulating hormone modulates nitric oxide production in melanocytes (2000) |
| Authors | Tsatmali M.;Graham A.;Szatkowski D.;Ancans J.;Manning P.;McNeil C.;Graham A.;Thody A. |
| Journal | Journal of Investigative Dermatology |
| DOI | 10.1046/j.1523-1747.2000.00879.x |