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researcher

Professor Anne Graham

Head of School of Chemistry & Bioscience

Faculty/Dept/School School of Chemistry and Bioscience
(Faculty of Life Sciences)
Emaila.graham@bradford.ac.uk
Telephone +441274 233570

Biography

Study of human endothelial cell genetic and functional responses in health and inflammatory disease (atherosclerosis, diabetes, cancer). These cells lining the blood vessels are master regulators of acute inflammation in health and chronic inflammation in disease. Low grade chronic inflammation at the blood vessel wall results in lesion formation and narrowing of the vessels (atherosclerotic plaques). Therefore cardiovascular disease and diabetes are key disorders where endothelial cells are dysfunctional. Skin disease such as psoriasis also have an important inflammatory vascular component. Intra-cellular signalling pathways important in endothelial cell proliferation, migration and apoptosis are currently under study in the Graham laboratory.

Outside the lab, interventions which reduce cardiovascular complications in diabetes, through development of patient self management is an active area of research, in collaboration with pharmacists and researchers in the School of Pharmacy and Medical Sciences and collaborators in Bangladesh (Professor Fatema Ashraf, Surawahardy  Hospital and Medical College

Research

Endothelial cell function in health and disease (atherosclerosis, diabetes, kidney disease, psoriasis) Mechanisms of compromised wound healing in chronic disease (diabetes). Epigenetic regulation of vascular cell function in diabetes. Mechanisms of angiogenesis relevant to cardiovascular disease and diabetes. 

 

Research collaborators
NameProfessor Jun Tao
CompanyFirst Affiliated Hospital, Sun Yat-Sen University
CountryCHINA
TypeE
RoleCommon interest in hypertension and cell signalling
Themehypertension and atherosclerosis
DescriptionDevelopment of projects for exchanges between groups
 

Teaching

Teaching highlights

We run engaging workshops where groups of final year students apply knowledge about MAP kinase signalling pathways from lectures to drug development for anti-cancer agents.

Second year Clinical and Analytical Biochemistry workshops allow students to diagnose medical  conditions based on clinical test results. Small group sessions build confidence and help develop understanding oc complex disease conditions.

Year Module code Title Subject
BIS6009-BResearch Topics 1 in Medical Biochemistry

Professional activities

  • 01-JAN-12: University of Bradford -  PGCert
  • 01-JAN-07: HEA - Fellow Higher Education Academy
  • 01-JAN-89: University of Glasgow - PhD
  • 01-JAN-86: Strathclyde University -  Bsc (Hons)
  • 01-JAN-13:  University of Bradford  - Acting Dean of Graduate Studies
  • 01-JAN-15:  University of Bradford  - Chair Director PGR Forum
  • 01-JAN-11:  University of Bradford  - Member Research Degrees Committee
  • 01-JAN-15:  University of Bradford  - Member Ethics Committee
  • 01-JAN-94: British Heart Foundation  -
  • 01-JAN-91: Wellcome Trust - Postdoctoral researcher
  • 08-JAN-18: NC3Rs, Studentship Grant Panel member
  • 01-JAN-15: Heart Research UK, Translational Grant Panel member
  • 01-FEB-16: Institute of Biomedical Science , Fellow
  • British Inflammation Research Association, Committee member
  • 01-AUG-14: Institute of Biomedical Science, Fellow
  • University Research & Knowledge Transfer Research Strategy Committee,
  • Senate, Represent Faculty of Life Sciences Research & Knowledge Transfer interests
  • Research & Knowledge Transfer
  • Chair Faculty Research KT Strategy committee
  • Chair Faculty PGR committee
  • Programme & Module Management: Deputy Chair University Research & Knowledge Transfer Strategy Committee
  • Other: Option Convenor Medical Biochemistry Option on BSc Biomedical Science (UoB and Singapore)
  • Programme & Module Management: Member of Faculty Executive committee
  • Academic Leadership: Chair of Faculty Research & Knowledge Transfer Committee
  • Academic Leadership: Chair of Faculty PGR Committee
  • Co-lead of a monthly public engagement with science meeting, in partnership with the National Science & Media Museum and Theatre in the Mill. Bringing scientists and refreshments to a local venue.
  • Fellow/Member/Chair/Role Model: Role Model for Aurora Programme - Leadership Foundation (2015/16 & 2016/17) Member of editorial board of Journal of Inflammation (2001- ) Researcher Development Framework Champion, Vitae (2012- ) UK Council for Graduate Education “Structures” working group member (2014- ) British Inflammation Research Association committee (2001- ) Fellow Institute of Biomedical Sciences (2014- ) Fellow Higher Education Academy (2007- ) Member of British Pharmacology Society (1992- ) Member of Biochemical Society (1992- ) Member of British Society for Immunology (1999- ) Grant review panel Chair for Heart Research UK (2009)

Publications

Peer Reviewed Journal
TitleIL-36γ is a strong inducer of IL-23 in psoriatic cells and activates angiogenesis (2018)
AuthorsBridgewood C.;Fearnley G.;Berekmeri A.;Laws P.;Macleod T.;Ponnambalam S.;Stacey M.;Graham A.;Wittmann M.
JournalFrontiers in Immunology
DOI10.3389/fimmu.2018.00200
 
TitlePlatelet microparticle delivered microRNA-Let-7a promotes the angiogenic switch (2018)
AuthorsAnene, Chinedu; Graham, Anne M.; Boyne, James R.; Roberts, Wayne
 
TitleIL-36y is a strong inducer of IL-23 in psoriatic cells and activates angiogenesis (2018)
AuthorsBridgewood, Charlie; Fearnley, G.W.; Berekmeri, A.; Laws, P.; Macleod, T.; Ponnambalam, S.; Stacey, M.; Graham, Anne M.; Wittman, Miriam
 
TitleIL-36γ has proinflammatory effects on human endothelial cells (2017)
AuthorsBridgewood, Charlie; Stacey, M.; Alase, Adewonuola A.; Lagos, D.; Graham, Anne M.; Wittmann, Miriam
 
TitleThe Role of Maternal Gestational Diabetes in Inducing Fetal Endothelial Dysfunction (2015)
AuthorsSultan, S.A.; Liu, Wanting; Peng, Yonghong; Roberts, Wayne; Whitelaw, D.C.; Graham, Anne M.
 
TitleReed-Sternberg cell-derived lymphotoxin-a activates endothelial cells to enhance T-cell recruitment in classical Hodgkin lymphoma (2014)
AuthorsFhu, C.W.; Graham, Anne M.; Yap, C.T.; Al-Salam, S.; Castella, A.; Chong, S.M.; Lim, Yaw-Chyn
 
TitleAn in vitro model of warm hypoxia-reoxygenation injury in human liver endothelial cells (2012)
AuthorsBanga N.;Prasad K.;Burn J.;Homer-Vanniasinkam S.;Graham A.
JournalJournal of Surgical Research
DOI10.1016/j.jss.2011.12.036
 
TitleChronic homocysteine exposure upregulates endothelial adhesion molecules and mediates leukocyte: Endothelial cell interactions under flow conditions (2011)
AuthorsAlkhoury K.;Parkin S.;Homer-Vanniasinkam S.;Graham A.
JournalEuropean journal of vascular and endovascular surgery : the official journal of the European Society for Vascular Surgery
DOI10.1016/j.ejvs.2010.11.012
 
TitlePathogenic mechanisms in varicose vein disease: The role of hypoxia and inflammation (2010)
AuthorsHossein Ghaderian S.;Lindsey N.;Graham A.;Homer-Vanniasinkam S.;Najar R.
JournalPathology
DOI10.3109/00313025.2010.493865
 
TitleThe Impact of Different Concentrations of Sodium Tetradecyl Sulphate and Initial Balloon Denudation on Endothelial Cell Loss and Tunica Media Injury in a Model of Foam Sclerotherapy (2010)
AuthorsIkponmwosa A.;Abbott C.;Graham A.;Homer-Vanniasinkam S.;Gough M.
JournalEuropean journal of vascular and endovascular surgery : the official journal of the European Society for Vascular Surgery
DOI10.1016/j.ejvs.2009.12.025
 
TitleGlobular adiponectin induces platelet activation through the collagen receptor GPVI-Fc receptor γ chain complex (2008)
AuthorsRiba R.;Hughes C.;Graham A.;Watson S.;Naseem K.
JournalJournal of Thrombosis and Haemostasis
DOI10.1111/j.1538-7836.2008.02982.x
 
TitleSimvastatin alters human endothelial cell adhesion molecule expression and inhibits leukocyte adhesion under flow (2008)
AuthorsEccles K.;Sowden H.;Porter K.;Parkin S.;Homer-Vanniasinkam S.;Graham A.
JournalAtherosclerosis
DOI10.1016/j.atherosclerosis.2007.12.018
 
TitlecGMP-independent inhibition of integrin alphaIIbbeta3- mediated platelet adhesion and outside-in signalling by nitric oxide (2007)
AuthorsGraham, Anne M.; Naseem, Khalid M.; Oberprieler, Nikolaus G.; Riba, Rocio; Roberts, Wayne; Homer-Vanniasinkam, Shervanthi
 
TitlecGMP-independent inhibition of integrin αIIbβ3-mediated platelet adhesion and outside-in signalling by nitric oxide (2007)
AuthorsOberprieler N.;Roberts W.;Graham A.;Homer-Vanniasinkam S.;Naseem K.
JournalFEBS Letters
DOI10.1016/j.febslet.2007.02.072
 
TitleInhibition of ADP-induced platelet adhesion to immobilised fibrinogen by nitric oxide: evidence for cGMP-independent mechanisms. (2007)
AuthorsGraham, Anne M.; Homer-Vanniasinkam, Shervanthi; Naseem, Khalid M.; Oberprieler, Nikolaus G.; Roberts, Wayne
 
TitleToll-like receptor-mediated responses of primary intestinal epithelial cells during the development of colitis (2005)
AuthorsSingh J.;Cruickshank S.;Newton D.;Wakenshaw L.;Graham A.;Lan J.;Lodge J.;Felsburg P.;Carding S.
JournalAmerican Journal of Physiology - Gastrointestinal and Liver Physiology
DOI10.1152/ajpgi.00377.2004
 
TitleThe effects of margination and red cell augmented platelet diffusivity on platelet adhesion in complex flow (2004)
AuthorsJordan A.;David T.;Homer-Vanniasinkam S.;Graham A.;Walker P.
JournalBiorheology
 
TitleToll-like receptor-mediated responses of primary intestinal epithelial cells during the development of colitis (2004)
AuthorsSingh, J.C.I.; Cruickshank, S.M.; Newton, D.J.; Wakenshaw, L.; Graham, Anne M.; Lan, J.; Lodge, J.P.A.; Felsburg, P.J.; Carding, S.R.
 
TitleNuclear factor kappa B is involved in lipopolysaccharide- stimulated induction of interferon regulatory factor-1 and GAS/GAF DNA-binding in human umbilical vein endothelial cells. (2001)
AuthorsGraham, Anne M.; Bryant, C.; Liu, L.; Plevin, R.; Andrew, P.; Mackenzie, C.
 
TitleHuman monoclonal anti-endothelial cell IgG-derived from a systemic lupus erythematosus patient binds and activates human endothelium in vitro (2001)
AuthorsYazici Z.;Raschi E.;Patel A.;Testoni C.;Borghi M.;Graham A.;Meroni P.;Lindsey N.
JournalInternational Immunology
DOI10.1093/intimm/13.3.349
 
TitleHuman monoclonal anti-endothelial cell IgG-derived from a systemic lupus erythematosus patient binds and activates human endotheliium in vitro. (2001)
AuthorsYazici, Zihni A.; Raschi, E.; Patel, Anjana; Testoni, C.; Borghi, M.O.; Graham, Anne M.; Meroni, P.L.; Lindsey, Nigel J.
 
Titleα-Melanocyte-stimulating hormone modulates nitric oxide production in melanocytes (2000)
AuthorsTsatmali M.;Graham A.;Szatkowski D.;Ancans J.;Manning P.;McNeil C.;Graham A.;Thody A.
JournalJournal of Investigative Dermatology
DOI10.1046/j.1523-1747.2000.00879.x