Dr Krzysztof Poterlowicz
Senior Lect in Bioinformatics & Biostat
| Faculty/Dept/School |
School of Chemistry and Bioscience (Faculty of Life Sciences) |
|---|---|
| k.poterlowicz1@bradford.ac.uk | |
| Telephone | +441274 234737 |
Biography
I graduated in mathematics and applied statistics at the University of Wroclaw in Poland and continued my education at the University of Bradford studying computational modelling of the yeast cell cycle and obtained a MPhil degree in Bioinformatics. In 2009 I visited the Biotechnology Research Institute of the National Research Council Canada where my research involved computer simulation of molecular signalling cascades governing the development and differentiation of skin appendages. In 2010 I was awarded a ESPRC PhD fellowship in the Centre of Skin Sciences, University of Bradford. My PhD research project on the bioinformatics analyses of multi-level transcriptional and epigenetic regulation of epidermis resulted in a number of publications (Journal of Cell Biology, FASEB, Development and Journal of Investigative Dermatology) and Best Paper Prize at the World Congress of Hair Research in Edinburgh in 2013. The same year I joined the Faculty of Life Sciences at the University of Bradford as a Lecturer in Bioinformatics where I teach computational biology, medical genetics and statistics. My lab is involved in the national and international focus groups (Elixir, The Carpentries, Galaxy Training Network, Northern BUG) with aim to develop and provide bioinformatics and medical informatics training for research students and staff.
Research
I have a principal interest in development of computational method for identification of biomarkers that influence tissue regeneration and disease.Some of my group recent projects include:
- EWAS-Galaxy: a tools suite for population epigenetics integrated into Galaxy
- The use of machine learning in the assessment of burn injuries
Publications
| Peer Reviewed Journal | |
|---|---|
| Title | Interplay of MicroRNA-21 and SATB1 in Epidermal Keratinocytes during Skin Aging. (2019) |
| Authors | Ahmed MI;Pickup ME;Rimmer AG;Alam M;Mardaryev AN;Poterlowicz K;Botchkareva NV;Botchkarev VA; |
| Journal | Journal of Investigative Dermatology |
| DOI | 10.1016/j.jid.2019.04.022 |
| Title | Cellular sheddases are induced by Merkel cell polyomavirus small tumour antigen to mediate cell dissociation and invasiveness (2019) |
| Authors | Nwogu, N.; Boyne, James R.; Dobson, S.J.; Poterlowicz, Krzysztof; Blair, G.E.; Macdonald, A.; Mankouri, J.; Whitehouse, A. |
| Title | MCV-miR-M1 targets the host-cell immune response resulting in the attenuation of neutrophil chemotaxis (2018) |
| Authors | Akhbari, Pouria; Tobin, Desmond J.; Poterlowicz, Krzysztof; Roberts, W.; Boyne, James R. |
| Title | The cellular chloride channels CLIC1 and CLIC4 contribute to virus-mediated cell motility (2018) |
| Authors | Stakaityte, G.; Nwogu, N.; Lippiat, J.D.; Blair, G.E.; Poterlowicz, Krzysztof; Boyne, James R.; Macdonald, A.; Mankouri, J.; Whitehouse, A. |
| Title | 5C analysis of the Epidermal Differentiation Complex locus reveals distinct chromatin interaction networks between gene-rich and gene-poor TADs in skin epithelial cells (2017) |
| Authors | Poterlowicz K.;Yarker J.;Malashchuk I.;Lajoie B.;Mardaryev A.;Gdula M.;Sharov A.;Kohwi-Shigematsu T.;Botchkarev V.;Fessing M. |
| Journal | PLoS Genetics |
| DOI | 10.1371/journal.pgen.1006966 |
| Title | p63 Transcription Factor Regulates Nuclear Shape and Expression of Nuclear Envelope-Associated Genes in Epidermal Keratinocytes (2017) |
| Authors | Rapisarda V.;Malashchuk I.;Asamaowei I.;Poterlowicz K.;Fessing M.;Sharov A.;Karakesisoglou I.;Botchkarev V.;Mardaryev A. |
| Journal | Journal of Investigative Dermatology |
| DOI | 10.1016/j.jid.2017.05.013 |
| Title | Inhibition of HOX/PBX dimer formation leads to necroptosis in acute myeloid leukemia cells (2017) |
| Authors | Alharbi, R.A.; Pandha, H.S.; Simpson, G.R.; Pettengell, R.; Poterlowicz, Krzysztof; Thompson, A.; Harrington, K.J.; El-Tanani, Mohamed; Morgan, Richard |
| Title | p63 transcription factor regulates nuclear shape and expression of nuclear envelope-associated genes in epidermal keratinocyte (2017) |
| Authors | Rapisarda, Valentina; Malashchuk, Igor; Asamaowei, Inemo E.; Poterlowicz, Krzysztof; Fessing, Michael Y.; Sharov, A.A.; Karakesisoglou, I.; Botchkarev, Vladimir A.; Mardaryev, Andrei N. |
| Title | Circulating tumour DNA: a minimally invasive biomarker for tumour detection and stratification (2016) |
| Authors | Surani, Arif A.; Poterlowicz, Krzysztof |
| Title | Cbx4 maintains the epithelial lineage identity and cell proliferation in the developing stratified epithelium (2016) |
| Authors | Mardaryev, Andrei N.; Liu, B.; Rapisarda, Valentina; Poterlowicz, Krzysztof; Malashchuk, Igor; Rudolf, Jana; Sharov, A.A.; Jahoda, C.J.; Fessing, Michael Y.; Benitah, S.; Xu, G.; Botchkarev, Vladimir A. |
| Title | Bone morphogenetic protein signaling suppresses wound-induced skin repair by inhibiting keratinocyte proliferation and migration (2014) |
| Authors | Lewis, Christopher J.; Mardaryev, Andrei N.; Poterlowicz, Krzysztof; Sharova, T.Y.; Aziz, A.; Sharpe, David T.; Botchkareva, Natalia V.; Sharov, A.A. |
| Title | MicroRNA-214 controls skin and hair follicle development by modulating the activity of the Wnt pathway (2014) |
| Authors | Ahmed, Mohammed I.; Alam, Majid A.; Emelianov, V.U.; Poterlowicz, Krzysztof; Patel, Ankit; Sharov, A.A.; Mardaryev, Andrei N.; Botchkareva, Natalia V. |
| Title | Complex Changes in the Apoptotic and Cell Differentiation Programs during Initiation of the Hair Follicle Response to Chemotherapy (2014) |
| Authors | Sharova, T.Y.; Poterlowicz, Krzysztof; Botchkareva, Natalia V.; Kondratiev, N.A.; Aziz, A.; Spiegel, J.H.; Botchkarev, Vladimir A.; Sharov, A.A. |
| Title | p63 and Brg1 control developmentally regulated higher-order chromatin remodelling at the epidermal differentiation complex locus in epidermal progenitor cells (2014) |
| Authors | Mardaryev, Andrei N.; Gdula, Michal R.; Yarker, Joanne L.; Emelianov, V.U.; Poterlowicz, Krzysztof; Sharov, A.A.; Sharova, T.Y.; Scarpa, J.A.; Chambon, P.; Botchkarev, Vladimir A.; Fessing, Michael Y. |
| Title | Genome organizing function of SATB1 in tumor progression. (2013) |
| Authors | Kohwi-Shigematsu, T.; Poterlowicz, Krzysztof; Ordinario, E.; Han, H.J.; Botchkarev, Vladimir A.; Kohwi, Y. |
| Title | Remodeling of Three-Dimensional Organization of the Nucleus during Terminal Keratinocyte Differentiation in the Epidermis (2013) |
| Authors | Gdula, Michal R.; Poterlowicz, Krzysztof; Mardaryev, Andrei N.; Sharov, A.A.; Fessing, Michael Y.; Botchkarev, Vladimir A.; Peng, Yonghong |
| Title | Characterization of Changes in the Proteome in Different Regions of 3D Multicell Tumor Spheroids (2012) |
| Authors | McMahon, Kelly M.; Volpato, Milène; Chi, H.Y.; Musiwaro, P.; Poterlowicz, Krzysztof; Peng, Yonghong; Scally, Andy J.; Patterson, Laurence H.; Phillips, Roger M.; Sutton, Chris W. |
| Title | Cigarette smoke-induced transgenerational alterations in genome stability in cord blood of human F1 offspring (2012) |
| Authors | Laubenthal, Julian; Zlobinskaya, O.; Poterlowicz, Krzysztof; Baumgartner, Adolf; Gdula, Michal R.; Fthenou, E.; Keramarou, M.; Hepworth, S.J.; Kleinjans, J.C.; van Schooten, F.J.; Brunborg, G.; Godschalk, R.W.; Schmid, Thomas E.; Anderson, Diana |
| Title | p63 regulates Satb1 to control tissue-specific chromatin remodeling during development of the epidermis (2011) |
| Authors | Fessing, Michael Y.; Mardaryev, Andrei N.; Gdula, Michal R.; Sharov, A.A.; Sharova, T.Y.; Rapisarda, Valentina; Gordon, K.B.; Smorodchenko, A.D.; Poterlowicz, Krzysztof; Ferone, G.; Kohwi, Y.; Missero, C.; Kohwi-Shigematsu, T.; Botchkarev, Vladimir A. |
| Title | Lhx2 differentially regulates Sox9, Tcf4 and Lgr5 in hair follicle stem cells to promote epidermal regeneration after injury (2011) |
| Authors | Mardaryev, Andrei N.; Meier, N.; Poterlowicz, Krzysztof; Sharov, A.A.; Sharova, T.Y.; Ahmed, Mohammed I.; Rapisarda, Valentina; Lewis, Christopher J.; Fessing, Michael Y.; Ruenger, T.M.; Bhawan, J.; Werner, S.; Paus, R.; Botchkarev, Vladimir A. |
| Title | BMP signaling induces cell-type-specific changes in gene expression programs of human keratinocytes and fibroblasts (2010) |
| Authors | Fessing, Michael Y.; Atoyan, R.; Shander, B.; Mardaryev, Andrei N.; Botchkarev, V.V. Jr; Poterlowicz, Krzysztof; Peng, Yonghong; Efimova, T.; Botchkarev, Vladimir A. |