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PHD Studentship: Investigation the molecular basis of cataract formation

Full-time: available
Part-time: not available
Prospective PG students (inc. current UG): available
Current PG students: not available
Entry year: 2021/22
Undergraduate: not available
Postgraduate taught: not available
Postgraduate research: available

About the award

Cataracts are the leading cause of age-related blindness worldwide and currently surgeInvestry is the only available treatment. To develop more accessible treatments (such as eye drops), detailed molecular mechanisms of how cataracts develop must be elucidated. Cataracts develop when crystallin proteins in the lens, aggregate into cloudy/opaque deposits that obstruct vision.  Using a combination of state-of-the-art time-resolved X-ray crystallographic techniques, in vitro and cell-based assays this interdisciplinary project aims to:

• Investigate UV-induced conformational changes and aggregation of purified native and γ-D crystallin mutants

• Resolve the aggregation of native and mutant γ-D crystallin and changes in chaperone secretion in lens epithelial cells.

• Model how structural changes of γ-D crystallin lead to aggregation and cataract formation.

Candidates are expected to hold (or be about to obtain) a minimum upper second-class honours degree (or equivalent) in a related area such as Biochemistry, Cell Biology, Biomedical Sciences, or Structural Biology. Although training will be provided, experience in techniques such as site directed mutagenesis, protein purification, mammalian cell culture, immunofluorescence microscopy, SDS-PAGE, immunoprecipitation, and spectroscopy techniques will be an added advantage.

Eligibility criteria

Candidates are expected to hold (or be about to obtain) a minimum upper second-class honours degree (or equivalent) in a related area such as Biochemistry, Cell Biology, Biomedical Sciences, or Structural Biology. Although training will be provided, experience in techniques such as site directed mutagenesis, protein purification, mammalian cell culture, immunofluorescence microscopy, SDS-PAGE, immunoprecipitation, and spectroscopy techniques will be an added advantage.

Eligible countries

Students from all countries, who meet the criteria, are eligible.



Payment amount & frequency

This project has full funding for UK students, which will cover tuition and bench fees, and a stipend for living costs. Non-UK students, including those from EU countries, may be considered but would need to self-fund the difference between UK and International fees

How to apply

Applicants should apply via the following link

Application deadline: 26 March 2021

 

Find out more

For informal enquiries, please contact: research@bradford.ac.uk 

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