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Supporting Analytical Techniques

Structural and Molecular AnalysisBruker PXRD

  • PXRD
  • NMR
  • Raman and IR  Spectroscopy
  • Mass Spectrometry

Thermal Analysis

  • Direct Scanning Calorimetry (DSC)
  • Thermal Gravimetric Analysis (TGA)
  • Dynamic Mechanical Analysis (DMA)

Chromatographic Analysis   HPLC image

  • uHPLC (Waters)
  • Gel Permeation Chromatography 
  • Gas Chromatography (Agilent)

Powder/Particle Characterisation

  • Particle Morphology/Size-Environmental Scanning Electron Microscopy (ESEM)-Quanta 400 (FEI)
  • Hygroscopicity/amorphous content- Intrinsic Dynamic Vapour Sorption (DVS) (SMS)
  • Particle Size Analysis (powders)-Laser Diffraction HELOS/KF Rodos-M range 1-100microns (Sympatec)
  • Particle Size Analysis/Zeta potential (suspensions/emulsions)-DLS NanoSizerS range 10nm-103nm(Malvern)
  • Surface Area Measurements (BET)- iGC Surface Energy Analyser (SMS)
  • Surface Energy Measurements -iGC Surface Energy Analyser includes film surface analysis option (SMS)
  • Particle or True Density- Helium Pycnometry- AccuPyc 1330 (Micrometrics)
  • Compressibility-Texture Analyser TA XP+ (Stable Microsystems)
  • Flowability- Angle of repose method-Texture Analyser TA XP+ (Stable Microsystems)
  • Rheometry- Rotational and Capillary Rheometers-(AntonParr)
  • KF Moisture analysis- 701 KF Titrino (Metrohm)
  • Loss on Drying (LOD)- Halogen moisture balance  (Mettler Toledo)

Physical Characterisation

  • Capillary rheometer for extensional rheology, die swell and slip plane studiesRotational Rheometry
  • Rotational rheometer
  • Atomic Force Microscope 
  • Hardness Testing- 4M Hardness Tester (Schleuniger)
  • Friability Testing-(Copley Scientific Instruments)
  • Compactness Testing- Texture Analyser TA XP+ (Stable Microsystems)
  • Osmometer 

Dissolution/Disintegration Testing

Dissolution Testing

  • USP II – DS800 with sample collector (Lab India)
  • USP IV- USP Apparatus 4 Flow-Through Cell Dissolution Systems CP7 (Sotax)

Disintegration Testing

  • Disintegration testing station DTG 3000 (Copley Scientific)‌

In-line dissolution/disintegration studies for real-time particle size analysisgeneral analysis image

  • Particle Visual Microscopy (PVM) “Particle View” Probe (Mettler Toledo)
  • Focused Beam Reflectance Measurement (FBRM) G400 (Mettler Toledo)