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Preclinical Pharmacology

ICT Biosciences has considerable  expertise in preclinical pharmacology, especially in the cancer field.

Our key areas of expertise include:

Target Identification and Characterisation

  • Immunohistochemistry
  • Tissue and tumour arrays
  • Gene expression
  • Tumour/normal differential expression evaluation
  • Development of genetically modified experimental models
  • Drug-target interaction evaluation
  • Analysis of molecular pharmacology of drug action

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Cellular Cytotoxicity

  • MTT/SRB microplate cytotoxicity assays
  • Clonogenic assay
  • Tumour versus normal cell response
  • Drug response in three-dimensional tumour spheroids

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Cellular Growth Inhibition Evaluation

  • Cell cycle analysis
  • Apoptosis/cell death induction
  • Mechanistic studies

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Tumour Xenograft Models

  • Human and other tumour cell lines
  • High expression vs. low/negative expression
  • Isogenic tumour models 
  • Direct measurement of anti-tumour response
  • Tumour vasculature analysis
  • Histological analysis
  • Biochemical analysis
  • Assessment of tumourigenicity
  • Efficacy and PK/PD analysis of small molecules
  • Efficacy and PK/PD analysis of biologics

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Hollow Fibre Assay

We evaluate:

  • Anti-proliferative activity
  • Pharmacodynamic endpoints
  • Drug effects in non-tumourigenic cell lines
  • Vascular targeting agents

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Site Specific Tumours

We evaluate:

  • Response  in specific site e.g. colon
  • Response at site of metastasis e.g. liver, lung

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Cell lines & Xenografts

ICT Biosciences has access to an extensive range of human tumour cell lines including lines in the NCI-60 panel.  These cell lines are available for use in in vitro assays with many having been validated for use as subcutaneous xenograft models for efficacy studies.

Cell lines and xenograft models are available for various cancer types including:

  • Bladder
  • Breast
  • Colon
  • Melanoma
  • Ovarian
  • Prostate
  • Pancreas
  • Renal
  • SCLC

In addition we have murine colon adenocarcinoma (MAC) models available.

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Further information

Upcoming events

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