Module code: MHT7013-B
To stimulate a multidisciplinary understanding of the concepts underlying regenerative medicine (tissue engineering and wound repair).
This course will provide an overview of cell culture fundamentals, an extensive review on extracellular matrix, followed by topics on cell-cell and cell-matrix interactions. Subsequent lectures will cover the effects of physical (shear, stress, strain), chemical (Cytokines, growth factors), and electrical stimuli on cellular behaviour once cells attach to biomaterials as scaffolds. Tissue engineering will be introduced by reviewing tissue structure and function and the clinical need for tissue repair. An overview of scaffold design and processing for
tissue engineering will be reviewed and the application of tissue engineering to specialized tissues and organs will then be addressed in depth. Tissue engineering of specific organ systems will be discussed include skin, muscular skeletal system (vascular grafts, blood substitutions, cardiac patch, and heart valve), nervous system (peripheral and central nervous systems), liver, pancreas, and kidney. History and fundamentals of tissue engineering; Cell sources; Tissue dynamics/cell migration; Biomaterials for tissue engineering; Bioreactors and cell culture techniques such as: sample and supplement preparation; cell counting and cell passage will be discuss in details. Weeks 1: Course Structure and Introduction Weeks 2: History of Cell and Tissue Engineering Weeks 3: Basic Concept Weeks 4: Getting started in the lab Weeks 5: Essential lab skills for Tissue Engineering (Part 1) Weeks 6: Essential lab skills for Tissue Engineering (Part 2) Weeks 7: Essential lab skills for Tissue Engineering (Part 3) Weeks 8: Cell and tissue isolation Weeks 9: Tissue Engineering Application (Bone, and Cartilage and Breast) Weeks 10: Tissue Engineering Application (Cornea, skin and hair) Weeks 11: Problem Based Learning 1 plus Presentation) Weeks 12: Problem Based Learning 2 plus Presentation 2