Module code: MHT7011-B
To engender specialist knowledge and understanding of the principles of bioinformatics and how information technology can be applied to problems in computational biology and clinical medicine. To develop mathematical skills in relation to bioinformatics and an understanding of the role of information technology in the genomic revolution.
What is bioinformatics? The role of information technology in biology and medicine. Elementary information theory. Elementary coding theory.
Nature of information. Information encoding, storage and transmission. Error-correcting codes. Elementary statistics. Expected distributions. Genomic alphabet. Proteomic alphabet. Genomic information coding. Sequence analysis. Sequence alignment. Pattern matching. Pattern discovery. Applications to taxonomy and phylogeny. Motif discovery. Codons, scriptons, cistrons and replicons. Regulatory sequences. Spectral analysis and the periodogram. Automated discovery of ORFs. Making a Mammoth (Nature study paper) Implications for understanding of evolution.