Module code: INC7005-B
To provide students with the opportunity to develop
- Knowledge of the subject of toxicology and safety pharmacology
- A systematic an critical understanding of this subject area
- Understanding of the role of toxicology safety pharmacology in the context of drug development
- The ability to effectively communicate scientific concepts
- Relevant laboratory skills
There are two major themes within this module. The first is designed to inform students of current practise in Toxicology and will focus on the regulatory and experimental areas of the field, including Genotoxicity, Mutagenicity, Carcinogenicity, Reproductive Toxicology, Dermal Toxicology and Immunotoxicology. Principles of risk assessment and drug absorption, distribution and metabolism will also be covered. The second theme of this module will concentrate on the drug development process, with particular attention on the screening methods used, discovery toxicology and predictive toxicology screening. This will involve description of in silico, in vitro and other short term toxicity screening methods. In addition the need for in vivo screening tests will be discussed. Specific examples will be used to describe the process. Students will develop their ability to work both individually and in small groups during laboratory work. They will extend their literature searching, presentation and report writing skills in preparing a journal club, and preclinical drug safety report.
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