Module code: INC7001-B
To provide students with the opportunity to develop
- The knowledge and ability to solve complex problems and justify their decisions.
- Techniques for current and critical evaluation of pre-clinical models used to evaluate potential anti-cancer drugs.
- Training in the legislation of in vivo experimentation techniques leading to a successful application to the Home Office for a personal licence to undertake basic animal work.
- An understanding of the ethics involved in experimental work with animals.
- The ability to reflect on their practice to inform and plan their professional development.
Topics to be covered include; in vitro based experimental models, biochemical assays for investigating drug target interactions, toxicology (in vitro and in vivo), in vivo models including syngeneic, xenografts and orthotopic models, novel molecular models of tumour biology, non-invasive imaging techniques, endpoint analysis for assessing efficacy and ethical issues associated with animal usage (the 3R's). Emphasis will be placed upon a critical analysis of the value of experimental models in terms of how data obtained in the laboratory setting translates into clinical activity and current or emerging issues in this field, particularly with regards to the ethics of animal testing.
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