Module code: BIS4010-B
To promote knowledge of the basic principles of human genetics and developmental biology and understanding of the origin and function of gametes and stem cells. To consider the role of genes, mutations, chromosomal aberrations and aneuploidy in the cause and incidence of human disease. To study some of the molecular mechanisms that underpin human genetic disease. To consider current issues in reproductive medicine and human genetics, and ethical approaches used for decision making in these fields.
Embryonic & foetal development of the reproductive system and the structure and function of gametes. The chromosome and inheritance, alleles, genes and linkage. Mendelian inheritance, dominant, co-dominant, recessive and sex-linked alleles. Early embryonic development and the origin of stem cells. Embryonic and foetal development in general and the mechanisms of maternal support. Methods for examining chromosomes and genes. The molecular biology of the gene, the cell cycle and its control, simple and complex models. Mitosis and meiosis, timing, errors of cell division and gametogenesis. Complex genetic disease, genetic disorders of reproduction, cancer genetics including introduction to proto-oncogenes, oncogenes and tumour suppresser genes and their role in the induction of cancer. Gene therapy, DNA profiling and ethical considerations of reproductive medicine and human genetics as a discipline
Laboratory work: Students will perform an ABO Blood typing experiment and complete a short formative test relating to this area. Students will also attend a formative workshop session to use recognised philosophical principles to discuss ethical issues of current interest in reproductive medicine.