Associate Dean Research and Knowledge Transfer
Expertise: Inflammation, cardiovascular disease, diabetes, endothelial cells, cell signalling, MAP kinase, angiogenesis, microRNA
Study of human endothelial cell genetic and functional responses in health and inflammatory disease (atherosclerosis, diabetes, cancer). These cells lining the blood vessels play a key role in acute inflammation in health and chronic inflammation in disease. Low grade chronic inflammation at the blood vessel wall results in lesion formation and narrowing of the vessels (atherosclerotic plaques). Therefore cardiovascular disease and diabetes are key disorders where endothelial cells are dysfunctional.
Skin disease such as psoriasis also have a vascular component. Endothelial cells also have the ability to sprout and develop new blood vessels (angiogenesis), which is physiologically important but can stimulate metastasis in cancer.
Intra-cellular signalling pathways important in endothelial cell proliferation, migration and apoptosis are currently under study in the Graham laboratory.