Novel continuous processing of pharmaceutical co-crystals
CPES in collaboration with Sichuan University, China has developed a novel continuous milling technology for manufacturing pharmaceutical co-crystals.
Solid state shear milling (S3M) is a scalable, continuous, polymer assisted co-crystallization technique. A specially designed milling pan was employed to provide high levels of applied shear, and the addition of a polymeric processing aid enabled generation of high stress fields. As an example of the technology carbamazepine−salicylic acid co-crystals were produced with 5−25 wt % of poly (ethylene oxide) (PEO). A systematic study was carried out to understand the effect of process variables on properties and performance of the co-crystals. S3M offers an important new route for continuous manufacturing of pharmaceutical co-crystals.
Schematic of continuous co-crystallization using S3M technology
Open Access Article Link: https://pubs.acs.org/doi/abs/10.1021/acs.cgd.7b01733