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Dr Jacobo Elies

PositionLecturer in Pharmacology
LocationM26 Richmond Building
DepartmentPharmacy and Medical Sciences
Feedback Hours9:00-18:00
Telephone01274 232132
Emailj.eliesgomez@bradford.ac.uk
Twitter@EliesJacobo
ORCID0000-0002-2518-8412

Research Interests (key words only)

Molecular mechanisms of vascular function, ion channels, gasotransmitters, endothelial dysfunction, cardiovascular diseases, and autoimmune diseases.

Teaching and Supervisory Responsibilities

  • PHA5006-D Senses, Thoughts and Movement 1 (STM1)
  • PHA6009-D Senses, Thoughts and Movement 2 (SMT2)
  • PHA5005-C TRANSPORT 1 – Cardiovascular, Urinary and respiratory Systems (Labs)
  • PHA7014-B Pharmacy Special Studies (Stage 4, Sem 1): Student Selected Component
  • PHA5007-B Capability in Pharmacy (Stage 2, Sem 2): Student Selected Assignment
  • PHA6010-B Capability in Pharmacy (Stage 3, Sem1): Student Selected Component
  • CLS4007-B BIOLOGY for CLINICAL SCIENCES (Foundation Year)
  • CLS4002-B Cardiovascular, Respiratory and Renal (CRR, YEAR 1)
  • CLS4001-B SPECIAL STUDIES 1
  • CLS6003-D SPECIAL STUDIES and PERSONAL & PROFESSIONAL DEVELOPMENT 3 (SSPD3)

Administrative Responsibilities

  • Deputy MPharm Admissions Tutor
  • Module Leader of Biology for Clinical Sciences
  • Personal Academic Tutor

Study History

  • BPharm (Hons), University of Santiago de Compostela (USC), Spain 2004
  • PhD in Pharmacology at USC, Spain 2009

Professional History

  • Mar 2017 – Present: Lecturer in Pharmacology, University of Bradford
  • Sep 2015 – Jan 2017: Wellcome Trust ISSF Junior Investigator Development Fellow, Leeds Institute of Rheumatic and Musculoskeletal Medicine, University of Leeds
  • May – Jun 2015: Visiting Research Fellow, Excellence Cluster Cardio-Pulmonary System, University of Giessen, Germany
  • Sep 2012 – Aug 2015: Postdoctoral Research Fellow, Leeds Institute of Cardiovascular and Metabolic Medicine, University of Leeds
  • Jun – Aug 2012: Visiting Research Fellow, Institute of Biology and Molecular Genetics (IBGM), University of Valladolid, Spain
  • Sep 2009 – Aug 2012: Postdoctoral Research Fellow, Leeds Institute of Genetics, Health and Therapeutics, University of Leeds
  • Sep 2006 – Sep 2007: Visiting Research Fellow, Department of Pharmacology, University of Cambridge
  • Sep 2005 – Aug 2009: PhD student, Department of Pharmacology, University of Santiago de Compostela, Spain

Professional Activities

  • Memberships:
    Member of the Physiological Society
    Member of the British Pharmacological Society
    Member of the Spanish Pharmacological Society
    Director of the Society of Spanish Researcher in the UK (SRUK)
    Member of the Northern Cardiovascular Research Group
    Member of the Northern Vascular Biology Forum

  • Reviewer for Scientific Journals:
    Cell Calcium
    Neuroscience
    Clinical & Experimental Pharmacology and Physiology
    Scientific Reports

  • Organisation of Scientific Meetings:
    Scientific Seminar on Science Communication, 25 November 2017, Manchester
    Scientific Seminar on Epigenetics, 28 November 2016, Sheffield
    Early Career Research Conference on Cardiovascular and Diabetes, 10-11 September 2014, Leeds

Research Areas

My research focuses on the investigation of the molecular mechanisms involved in cardiovascular implications of autoimmune diseases. I am interested in the cardioprotective effects of natural dietary compounds like coumarins and other polyphenols.

Research Collaborations

  • Prof Chris Peers (University of Leeds)
  • Dr Francesco Del Galdo (Leeds Institute of Rheumatic and Musculoskeletal Medicine, University of Leeds)
  • Dr Manuel Campos-Toimil (University of Santiago de Compostela, Spain)
  • Dr Georgia Mavria (Leeds Institute of Cancer & Pathology, University of Leeds)
  • Dr Carmen Montesinos (University of Alicante, Spain)
  • Prof Norbert Wiessmann (ECCPS, University of Giessen, Germany)

Publications

  • Liakouli V, Elies J, El-Sherbiny YM, Scarcia M, Grant G, Abignano G, Derrett-Smith EC, Esteves F, Cipriani P, Emery P, Denton CP, Giacomelli R, Mavria G, Del Galdo F. Scleroderma fibroblasts suppress angiogenesis via TGF-β/caveolin-1 dependent secretion of pigment epithelium-derived factorAnn Rheum Dis. 2017 Dec 19.
  • Berrout J, Kyriakopoulou E, Moparthi L, Hogea AS, Berrout L, Ivan C, Lorger M, Boyle J, Peers C, Muench S, Jacobo Elies Gomez, Hu X, Hurst C, Hall T, Umamaheswaran S, Wesley L, Gagea M, Shires M, Manfield I, Knowles MA, Davies S, Suhling K, Gonzalez YT, Carragher N, Macleod K, Abbott NJ, Calin GA, Gamper N, Zygmunt PM, Timsah Z. TRPA1-FGFR2 binding event is a regulatory oncogenic driver modulated by miRNA-142-3pNat Commun2017; 8(1): 947.
  • Al-Owais MM, Hettiarachchi NT, Boyle JP, Scragg JL, Elies J, Dallas ML, Lippiat J, Steele DS & Peers C. Multiple mechanisms mediating carbon monoxide inhibition of voltage-gated K+ channel Kv1.5” Cell Death & Disease 2017; 8(11):e3163.
  • Elies J, Scragg JL, Boyle JP, Gamper N, Peers C. Regulation of the T-type Ca2+ channel Cav3.2 by hydrogen sulfide: Emerging controversies concerning the role of H2S in nociception. J Physiol. 2016; 594 (15):4119-29. 
  • Elies J, Johnson E, Boyle JP, Scragg JL, Peers C. H2S does not regulate proliferation via T-type Ca2+ channels. Biochem Biophys Res Commun. 2015; 461 (4): 659-64.
  • Peers C, Elies J, Gamper N. Novel ways to regulate T-type Ca2+ channels. Channels. 2015; 9 (2):68-9. 
  • Peers C, Boyle JP, Scragg JL, Dallas ML, Al-Owais MM, Hettiarachichi NT, Elies J, Johnson E, Gamper N, Steele DS. Diverse mechanisms underlying the regulation of ion channels by carbon monoxide. Br J Pharmacol. 2015; 172 (6): 1546-56.
  • Duckles H, Boycott HE, Al-Owais MM, Elies J, Johnson E, Dallas ML, Porter KE, Giuntini F, Boyle JP, Scragg JL, Peers C. HO-1 regulates cell proliferation via CO-mediated inhibition of T-type Ca2+ channels. Pflugers Arch. 2015; 467 (2):415-27. 
  • Elies J, Scragg JL, Dallas ML, Huang D, Huang S, Boyle JP, Gamper N, Peers C. Inhibition of T-type Ca2+ Channels by Hydrogen Sulfide. Adv Exp Med Biol 2015; 860: 353-60.
  • Duckles H, Al-Owais MM, Elies J, Johnson E, Boycott HE, Dallas ML, Porter KE, Boyle JP, Scragg JL, Peers C. T-Type Ca2+ Channel Regulation by CO: A Mechanism for Control of Cell Proliferation. Adv Exp Med Biol. 2015; 860: 291-300.
  • Elies J, Scragg JL, Huang S, Dallas ML, Huang D, MacDougall DA, Boyle JP, Gamper N, Peers C. Hydrogen sulfide inhibits Cav3.2 T-type Ca2+ channels. FASEB J. 2014; 28 (12): 5376-87. 
  • Elies J, Dallas ML, Boyle JP, Scragg JL, Duke A, Steele DS, Peers C. Inhibition of the cardiac Na⁺ channel Nav1.5 by carbon monoxide. J Biol Chem. 2014; 289 (23): 16421-9. 
  • García-Morales V, Cuíñas A, Elíes J, Campos-Toimil M. PKA and Epac activation mediates cAMP-induced vasorelaxation by increasing endothelial NO production. Vascul Pharmacol. 2014; 60 (3):95-101.
  • Boycott HE, Dallas ML, Elies J, Pettinger L, Boyle JP, Scragg JL, Gamper N, Peers C. Carbon monoxide inhibition of Cav3.2 T-type Ca2+ channels reveals tonic modulation by thioredoxin. FASEB J. 2013; 27 (8): 3395-407. 
  • Cuíñas A, Elíes J, Orallo F, Campos-Toimil M. Cyclic AMP relaxation of rat aortic smooth muscle is mediated in part by decrease of depletion of intracellular Ca2+ stores and inhibition of capacitative calcium entry. Vascul Pharmacol. 2013; 58 (1-2):98-104.
  • Elies J, Cuíñas A, MacDougall DA, Leiro J, Campos-Toimil M. t-Resveratrol down-regulates caveolin-1, up-regulates eNOS and reduces their interaction in VSMC and EC. Food Biosci. 2013; 1:31-38. 
  • Dallas ML, Yang Z, Boyle JP, Boycott HE, Scragg JL, Milligan CJ, Elies J, Duke A, Thireau J, Reboul C, Richard S, Bernus O, Steele DS, Peers C. Carbon monoxide induces cardiac arrhythmia via induction of the late Na+ current. Am J Respir Crit Care Med. 2012; 186 (7):648-56. 
  • Elíes J, Cuíñas A, García-Morales V, Orallo F, Campos-Toimil M. t-Resveratrol simultaneously increases cytoplasmic Ca2+ levels and NO release in human endothelial cells. Mol Nutr Food Res. 2011; 55 (8):1237-48.
  • Campos-Toimil M, Elies J, Orallo F. Cardiovascular effects of trans- and cis-resveratrol. Recent Progress in Medicinal Plants. Vol. 21: Phyto-pharmacology and Therapeutic Values III. VK Singh; DK Majumdar; JN Govil and RK. Sharma, eds. Stadium Press LLC, USA, 2008: 263-294. 
  • Campos-Toimil M, Elíes J, Alvarez E, Verde I, Orallo F. Effects of trans- and cis-resveratrol on Ca2+ handling in A7r5 vascular myocytes. Eur J Pharmacol. 2007; 577 (1-3): 91-9. 
  • Campos-Toimil M, Elíes J, Orallo F. t- and c-Resveratrol increase cytoplasmic calcium levels in A7r5 vascular smooth muscle cells. Mol Nutr Food Res. 2005; 49 (5): 396-404. 
  • Liakouli V, Elies J, El-Sherbiny YM, Scarcia M, Grant G, Abignano G, Derrett-Smith EC, Esteves F, Cipriani P, Emery P, Denton CP, Giacomelli R, Mavria G, Del Galdo F. Scleroderma fibroblasts suppress angiogenesis via TGF-β/caveolin-1 dependent secretion of pigment epithelium-derived factorAnn Rheum Dis. 2017 Dec 19.
  • Berrout J, Kyriakopoulou E, Moparthi L, Hogea AS, Berrout L, Ivan C, Lorger M, Boyle J, Peers C, Muench S, Jacobo Elies Gomez, Hu X, Hurst C, Hall T, Umamaheswaran S, Wesley L, Gagea M, Shires M, Manfield I, Knowles MA, Davies S, Suhling K, Gonzalez YT, Carragher N, Macleod K, Abbott NJ, Calin GA, Gamper N, Zygmunt PM, Timsah Z. TRPA1-FGFR2 binding event is a regulatory oncogenic driver modulated by miRNA-142-3pNat Commun2017; 8(1): 947.
  • Al-Owais MM, Hettiarachchi NT, Boyle JP, Scragg JL, Elies J, Dallas ML, Lippiat J, Steele DS & Peers C. Multiple mechanisms mediating carbon monoxide inhibition of voltage-gated K+ channel Kv1.5” Cell Death & Disease 2017; 8(11):e3163.

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