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Professor Anne Graham

PositionAssociate Dean Research and Knowledge Transfer
LocationH27, Richmond Building
DepartmentSchool of Chemistry and Biosciences
Feedback Hours9:00-17:30
Telephone+44 (0) 1274 233570
EmailA.Graham@bradford.ac.uk
Twitter@doctoranneg
ORCID0000-0002-1810-3927

Research Interests (key words only)

Inflammation, cardiovascular disease, diabetes, endothelial cells, cell signalling, MAP kinase, angiogenesis, microRNA

PhD Supervision

Current

  • Role of vitamin D in wound healing- Jing Tay (Y3)
  • Regulation of endothelial cell function in psoriasis- Charlie Bridgewood (Y3)
  • Mechanisms of smooth muscle cell dysfunction in pulmonary arterial hypertension- Nahid Sharmin (Y3)
  • Interventional study in improving diabetes patient care by community pharmacists- Nesrin Elhatib (Completing corrections 2017)

Completed

  • Epigenetic regulation of endothelial cell function by platelet microparticles- Anthony Anene (2017)
  • Mechanisms of endothelial cell damage by iron preparations in haemodialysis patients- Tareg Hadeiba (2015)
  • Effects of oestrogens on wound healing- Ola Kamala (2015)
  • Foetal Programming of endothelial cells from diabetic mothers- Samar Sultan (2013)
  • Development of new treatments for varicose vein disease Anna Ikponmowsa: (2013)
  • Mechanisms responsible for human liver regeneration Dhanny Gomez: (2011) 
  • Mechanisms responsible for homocysteine mediated damage to endothelial cells- Kenan Alkhoury (2010)
  • Effects of IRI and preconditioning on human sinusoidal liver endothelial cells Neal Banga: (2009)
  • Mechanisms of PPAR action in angiogenesis: Penny Reid: (2008)
  • The effects of stress on endothelial cells under flow conditions: Kirstie Eccles: (2006)
  • E-selectin polymorphisms in varicose vein development Mohammad Ghaderian: (2006)
  • Cell signalling pathways activated in gut epithelia by EPEC Ahmed Alzahrani: (2006)
  • Mechanisms of platelet regulation: Nikolaos Oberprieler – (2006)
  • Mechanisms of interaction of EPEC with intestinal epithelial cells: Lynette Crowther: (2002)
  • Endothelial cell signalling responses to stress: Dianne Cooper : (2001)

Teaching and Supervisory Responsibilities

  • BSc Biomedical Science (accredited by Institute of Biomedical Sciences)
  • BSc Healthcare Sciences (accredited by Institute of Biomedical Sciences)
  • MSc Biomedical Science
  • MSc Skin Sciences & Regenerative Medicine

BSc

  • FHEQ Level 4: Developing Professional Skills 1, Introductory Biochemistry
  • FHEQ Level 5: Developing Professional Skills 2, Clinical & Analytical Biochemistry
  • FHEQ level 6: Research Topics 1 in Medical Biochemistry, Research Topics 1 in Medical Cell Biology, Research Topics 1 in in Cancer Biology & Therapeutics, Biology of Disease, Research Topics 2, Research Project (40 credits including laboratory based supervision), Research Dissertations for Clinical Sciences

MSc

  • Critical Appraisal (20 credit dissertation), Experimental Design, Research Project (including 9 week laboratory supervision)
  • Personal Academic Tutoring on BSc Biomedical Science
  • Franchised BSc Biomedical Science (Singapore) - disseration supervision and marking and moderation of student work as per BSc Biomedical Science at UoB

Administrative Responsibilities

University

  • Deputy Chair University Research & Knowledge Transfer Strategy Committee

Faculty of Life Sciences

  • Member of Faculty Executive committee
  • Chair of Faculty Research & Knowledge Transfer Committee
  • Chair of Faculty PGR Committee

School of Chemistry & Biosciences

  • Member of Executive committee
  • Option Convenor Medical Biochemistry Option on BSc Biomedical Science (UoB and Singapore)

Biography

Study of human endothelial cell genetic and functional responses in health and inflammatory disease (atherosclerosis, diabetes, cancer). These cells lining the blood vessels play a key role in acute inflammation in health and chronic inflammation in disease. Low grade chronic inflammation at the blood vessel wall results in lesion formation and narrowing of the vessels (atherosclerotic plaques). Therefore cardiovascular disease and diabetes are key disorders where endothelial cells are dysfunctional.  Skin disease such as psoriasis also have a vascular component. Endothelial cells also have the ability to sprout and develop new blood vessels (angiogenesis), which is physiologically important but can stimulate metastasis in cancer. Intra-cellular signalling pathways important in endothelial cell proliferation, migration and apoptosis are currently under study in the Graham laboratory

Study History

  • University of Bradford 2011-2012 PGCert in Business Management (Merit)
  • HEA: 2007: Fellow Higher Education Academy
  • University of Glasgow 1986-1989 PhD Medical Biochemistry, “Experimental studies in bilirubin & haem biosynthesis” 
  • Strathclyde University 1982-1986 Bsc (Hons) Biochemistry & Pharmacology 2.i

Professional History

University

  • Acting Dean of Graduate Studies (2013-2014)
  • Chair Director PGR Forum (2015-2016)
  • Member Research Degrees Committee (2011-2015)
  • Member Ethics Committee (2015)

Faculty of Life Sciences

  • Director PGR, Faculty of Life Sciences (2011-2016)
  • Acting Head of School of Medical Sciences (2014-2015 and 2016/17)

School of Medial Sciences

  • Programme Lead BSc Biomedical Science (2014-2015)
  • Programme Lead BSc Biomedical Science (2002-2005)
  • Programme Lead BSc Pharmacology (2003-2005)
  • Lecturer in Biochemistry, University of Bradford (1996-2003)

British Heart Foundation (1994-1996)
Postdoctoral researcher, funded by Wellcome Trust (1991-1994)

Professional Activities

  • Role Model for Aurora Programme - Leadership Foundation (2015/16 & 2016/17)
  • Member of editorial board of Journal of Inflammation (2001- )
  • Researcher Development Framework Champion, Vitae (2012- )
  • UK Council for Graduate Education “Structures” working group member (2014- )
  • British Inflammation Research Association committee (2001- )
  • Fellow Institute of Biomedical Sciences (2014- )
  • Fellow Higher Education Academy (2007- )
  • Member of British Pharmacology Society (1992- )
  • Member of Biochemical Society (1992- )
  • Member of British Society for Immunology (1999- )
  • Grant review panel Chair for Heart Research UK (2009)

Research Areas

  • Endothelial cell function in health and disease (atherosclerosis, diabetes, psoriasis)
  • Role of the vascular system in wound healing in chronic disease (diabetes)
  • Epigenetic regulation of vascular cell function
  • Mechanisms of angiogenesis
  • Vascular cell dysfunction in diabetes and chronic kidney disease.

Current Projects

  • Mechanisms responsible for vascular complications in gestational diabetes
  • Regulation of endothelial cell function in psoriasis
  • Mechanisms of smooth muscle cell dysfunction in pulmonary arterial hypertension
  • Epigenetic regulation of endothelial cell function by platelet microparticles
  • Role of vitamin D in wound healing
  • Interventional study in improving diabetes patient care by community pharmacists

Research Collaborations

  • Professor Jun Tao, First Affiliated Hospital, Sun Yat-Sen University, Guangzhou, China: Epigenetic regulation of hypertension
  • Professor Rui-Ping Xiao, Peking University, Beijing, China: Cardiometabolic disease
  • Professor Quaobing Huang, Southern Medical University, Guangzhou, China: Cardiometabolic disese
  • Dr YC Lim, National University of Singapore- Identification of cell associated and soluble factors modulating inflammatory microenvironment in classical Hodgkin lymphoma
  • Professor Jameel Inal, Cellular and Molecular Immunology Research Centre, London Metropolitan University: Vascular cell microparticles
  • Dr K Porter, Reader in Cardiovascular Cell Biology, University of Leeds: Statins in endothelial cell function
  • Dr M Wittmann, Consultant Dermatologist, University of Leeds: Endothelial cell regulation in psoriasis
  • Dr T Nasim, Lecturer in Pharmacy, University of Bradford: Mechanisms of smooth muscle cell dysfunction in pulmonary arterial hypertension
  • Dr Jon Silcock, Senior Lecturer in Pharmacy, University of Bradford
  • Dr J Thornton, Senior lecturer, Centre for Skin Sciences, University of Bradford: Role of oestrogens in wound healing
  • Dr W Roberts, Lecturer in Medical Sciences, University of Bradford: Epigenetic control of endothelial function by platelet microparticles in diabetes
  • Dr E Bryant, Psychology lecturer at University of Bradford- Obesity and type 2 diabetes

Networks/Roles

  • UK Council for Graduate Education “Structures” working group member
  • Researcher Development Framework Champion, Vitae

Publications

See Anne's publications on Bradford Scholars.


Bridgewood CD, Stacey M, Alase A, Lagos D, Graham A, Wittmann M.(2016) IL-36 has pro-inflammatory effects on human endothelial cells. Experimental Dermatology Sep 27. doi: 10.1111/exd.13228. [Epub ahead of print

Sultan S, Liu W, Peng YH, Roberts W, Whitelaw D, Graham AM (2015) The role of maternal gestational diabetes in inducing fetal endothelial dysfunction Journal of Cellular Physiology 230, 2695-2705

Fhu CW, Graham AM, Yap CT, Al-Salam S, Castella A, Chong SM, Lim YC (2014) Reed Sternberg cell-derived lymphotoxin-α activates endothelial cells to enhance T cell recruitment in classical Hodgkin lymphoma. Blood. 2014 Aug 19. pii: blood-2014-05-576140

Banga NR, Prasad KR, Homer-Vanniasinkam S, Graham A (2012) An in vitro model of warm hypoxia-repoxygenation injury in human liver endothelial cells J Surg Res Epub PMID: 22472696

Alkhoury K, Homer Vanniasinkam S, Parkin SM, Graham AM (2011) Chronic homocysteine exposure upregulates endothelial adhesion molecules and mediates leukocyte:endothelial cell interactions under flow conditions EJVES 41, 429-435

Ghaderian HSM, Lindsey NJ, Graham AM, Najar RA (2010) Pathogenic mechanisms in varicose vein disease: the role of hypoxia and inflammation. Pathology 42, 446-453

Eccles KA, Porter K, Homer-Vanniasinkam S, Graham AM. (2008) Anti-inflammatory effects of statins on human endothelial cells. Atherosclerosis 200(1):69-79

Oberprieler NG, Roberts W, Riba R, Graham AM, Homer-Vanniasinkam S, Naseem KM (2007) cGMP-independent inhibition of integrin alphaIIb beta3-mediated platelet adhesion and outside-in signalling by nitric oxide. FEBS Letters 581, 1529-34

Oberprieler NG, Roberts W, Graham AM, Homer-Vanniasinkam S, Naseem KM (2007) Inhibition of ADP-induced platelet adhesion to immobilized fibrinogen by nitric oxide: Evicdence for cGMP independent mechanisms. Biochem Pharmacol 73, 1593-601

Gomez D, Homer-Vanniasinkam S, Graham AM, Prasad R (2007) Role of ischaemic preconditioning in liver regeneration following major liver resection and transplantation. World J Gastroenterol 13, 657-670

In the News/Media

Expert Opinion: Sugar Tax & Diabetes.

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