Dr Krzysztof Poterlowicz
|Position||Lecturer in Bioinformatics|
|Location||H38f-j, Richmond Building|
|Department||School of Chemistry and Bioscience|
|RKT Centre||Centre for Skin Sciences|
|Visit my LinkedIn profile|
Research Interests (key words only)
Bioinformatics, Biostatistics, Digital health, Epigenetics, Genomics, Skin
- Miss Katarzyna Murat (2016 -)
- Dr Kirsty Smith (2016- ) together with Profesor Desmond Tobin
Teaching and Supervisory Responsibilities
Module leadership (2017-2018):
- BIS7007-B and BIS7016-B Experimental design
- BIS7006-B Research and Analytical Methods
- BIS7007-B and BIS7016-B Experimental design
- BIS60011-B Medical Genetics
- CLS4008-B Special Studies 1
- CLS5002-B Genetics and Health
- CLS5005-B Special Studies 2
- CLS6003-D Special Studies and PPD3
Dr Poterlowicz graduated in mathematics and applied statistics at the Wroclaw University in Poland. He further continued his education at the University of Bradford studying computational modelling of the yeast cell cycle and obtained a MPhil degree in Bioinformatics.
In 2009 he visited the Biotechnology Research Institute of the National Research Council Canada where his research involved computer simulation of molecular signalling cascades governing the development and differentiation of skin appendages.
In 2010 he was awarded a ESPRC PhD fellowship in the Centre of Skin Sciences, University of Bradford. This allowed him to develop an expertise in bioinformatics and computational biology of transcriptional and epigenetic regulation in the epidermis. His PhD research project on the bioinformatics analyses of multi-level transcriptional and epigenetic regulation of epidermis together with internal and external collaborations resulted in a number of published articles in journals such as Journal of Cell Biology, FASEB, Development and Journalof Investigative Dermatology. Dr Poterlowicz was awarded the Best Paper Prize at the World Congress of Hair Research in Edinburgh in 2013. The same year he joined the Faculty of Life Sciences at the University of Bradford asa Lecturer in Bioinformatics. Dr Poterlowicz teaches computational biology, medical genetics and statistics and actes as a personal tutor to first year students of the biomedical science undergraduate program. He is a research active academic with interest in the identification of novel genomics biomarkers that influence tissue development and disease. He is involved in the international scientific collaborations (MRC UK-China Stem Cell Partnership Initiative grant) and his research is regulatory published in peer-review journals. Dr Poterlowicz actively works in the international focus groups with aim to develop and provide bioinformatics and medical informatics training for biomedical students and staff. He is an Associate Member of the EpiGenSys and a Member of the Royal Society of Biology.
- University of Bradford, School of Life Sciences (PhD, 2013)
- University of Bradford, School of Computing, Informatics and Media (MPhil, 2010)
- University of Wroclaw, Institute of Mathematics (MSc, 2005)
- Reviewer of the Journal of Investigative Dermatology
- Associate Member of the EpiGenSys
- Member of the Royal Society Biology
- Associate Fellow of the Higher Education Academy (AFHEA)
- Data and Software Carpentry Instructor
- Bioinformatics of Genomics and Epigenomics- Epigenomics of the Skin development and Disorders- Big biomedical Data Analytics
- Development of bioinformatics worflows
- The Galaxy workflow for epigenetic profiling of progressing melanoma
- 3D modelling of the genome
- Network modelling of miRNA-mRNA interactions during Hair Cycle
The Carpentries Instructor and Maintainer. Co-organized and taught the following carpentries workshops:
- Data Carpentry @ Kings College London, May 2018
- Data Carpentry @ Kings College London, February 2018
- Software Carpentry @ Oxford University, October 2017
- Software Carpentry @ Oxford University, December 2016
- Data Carpentry @ University of Leeds, October 2015
Akhbari P, Tobin D, Poterlowicz K, Roberts W, Boyne JR. MCV-miR-M1 targets the host-cell immune response resulting in the attenuation of neutrophil chemotaxis.
J Invest Dermatol. 2018 May 16. pii: S0022-202X(18)31958-4. doi:10.1016/j.jid.2018.03.1527. [Epub ahead of print] PubMed PMID: 29777657.
Stakaitytė G, Nwogu N, Lippiat JD, Blair GE, Poterlowicz K, Boyne JR, Macdonald A, Mankouri J, Whitehouse A. The cellular chloride channels CLIC1 and CLIC4 contribute to virus-mediated cell motility. J Biol Chem. 2018 Mar 23;293(12):4582-4590. doi: 10.1074/jbc.RA117.001343. Epub 2018 Feb 8. PubMed PMID: 29462791; PubMed Central PMCID: PMC5868249.
Alharbi RA, Pandha HS, Simpson GR, Pettengell R, Poterlowicz K, Thompson A, Harrington K, El-Tanani M, Morgan R. Inhibition of HOX/PBX dimer formation leads to necroptosis in acute myeloid leukemia cells. Oncotarget. 2017 Aug 7;8(52):89566-89579. doi: 10.18632/oncotarget.20023. eCollection 2017 Oct 27.PubMed PMID: 29163771; PubMed Central PMCID: PMC5685692.
Poterlowicz K, Yarker JL, Malashchuk I, Lajoie BR, Mardaryev AN, Gdula MR, Sharov AA, Kohwi-Shigematsu T, Botchkarev VA, Fessing MY. "5C analysis of the Epidermal Differentiation Complex locus reveals distinct chromatin interaction networks between gene-rich and gene-poor TADs in skin epithelial cells." PLoS Genet. 2017 Sep 1;13(9):e1006966. doi: 10.1371/journal.pgen.1006966. eCollection 2017 Sep. PubMed PMID: 28863138.
Alharbi RA, Pandha HS, Guy R. Simpson GR, Pettengell R, Poterlowicz K, Thompson A, Harrington K, El-Tanani M, Morgan R. "Inhibition of HOX/PBX dimer formation leads to necroptosis in acute myeloid leukemia cells." Oncotarget. 2017; 8:89566-89579. https://doi.org/10.18632/oncotarget.20023
Rapisarda V, Malashchuk I, Asamaowei IE, Poterlowicz K, Fessing MY, Sharov AA, Karakesisoglou I, Botchkarev VA, Mardaryev A. "p63 transcription factor regulates nuclear shape and expression of nuclear envelope-associated genes in epidermal keratinocytes." J Invest Dermatol. 2017 Oct;137(10):2157-2167 doi:10.1016/j.jid.2017.05.013. Epub 2017 Jun 6. PubMed PMID: 28595999; PubMed Central PMCID: PMC5610935.
Mardaryev AN, Liu B, Rapisarda V, Poterlowicz K, Malashchuk I, Rudolf J, Sharov AA, Jahoda CA, Fessing MY, Benitah SA, Xu GL, Botchkarev VA. "Cbx4 maintains the epithelial lineage identity and cell proliferation in the developing stratified epithelium". J Cell Biol. 2016
Ahmed MI, Alam M, Emelianov VU, Poterlowicz K, Patel A, Sharov AA, Mardaryev, AN, Botchkareva NV. "MicroRNA-214 controls skin and hair follicle development by modulating the activity of the Wnt pathway". J Cell Biol. 2014
T.Y. Sharova,K. Poterlowicz, N.V. Botchkareva , N.A. Kondratiev, A. Aziz, J.H. Spiegel, V.A. Botchkarev, A.A. Sharov "Complex changes in the apoptotic and cell differentiation programs duri ng initiation of the hair follicle response to chemotherapy" , Journal of Investigative Dermatology, 2014
A.N. Mardaryev, M.R. Gdula , J.L. Yarker , V.N. Emelianov, K. Poterlowicz , A.A. Sharov, T.Y. Sharova, J.A. Scarpa, P. Chambon, V.A. Botchkarev, M.Y. Fessing "p63 and Brg1 control developmentally regulated higher-order chromatin remodelling at the epidermal differentiation complex locus in epidermal progenitor cells", Development, 2014
C.J. Lewis, A.N. Mandrayev, K. Poterlowicz, T.Y. Sharova, A. Aziz, D.T. Sharpe, N.V. Botchkareva, A.A Sharov “Bone Morphogenetic Protein Signalling Suppresses wound-Induced Skin Repair by Inhibiting Keratinocyte Proliferation and Migration”, Journal of Investigative Dermatology, 2013
M.R. Gdula, K. Poterlowicz, A.N. Mandrayev, A.A. Sharov, Y. Peng, M.Y. Fessing, V.A. Botchkarev “Remodelling of three-dimensional organization of the nucleus during terminal keratinocyte differentiation in the epidermis”, Journal of Investigative Dermatology, 2013
T. Kohwi-Shigematsu, K. Poterlowicz, E. Ordinario, H.J. Han, V.A. Botchkarev, Y. Kohwi “Genome organizing function of SATB1 in tumor progression.” Seminars in Cancer Biology, 2012
J. Laubenthal, O. Zlobinskaya*, K. Poterlowicz*, M.R. Gdula, J.O. Linschooten, E. Fthenou, A. Baumgartner, F.J. van Schooten, T.E. Schmid, R.W. Godschalk and D. Anderson “Cigarette smoke-induced transgenerational alterations in genome stability in cord blood of human F1 offspring”, FASEB, 2012 Oct:26(10):3946-56 (* equal contribution)
K.M. McMahon, M. Volpato, H.Y. Chi, P. Musiwaro, K. Poterlowicz, Y. Peng, A.J. Scally, L.H. Patterson, R.M. Phillips, C.W. Sutton “Characterization of changes in the proteome in different regions of 3D multicell tumor spheroids” Journal of Proteome Research, 2012 May;11(5):2863-75
A.N. Mandrayev, N. Meier, K. Poterlowicz, A.A. Sharov, T. Sharova, M.I. Ahmed, V. Rapisarda, C. Lewis, M.Y. Fessing, T.M. Ruenger, J. Bhawan, S. Werner, R. Paus and V.A. Botchkarev “Lhx2 differentially regulates Sox9, Tcf4 and Lgr5 in hair follicle stem cells to promote epidermal regeneration after Injury” Development, 2011 Nov;138(22):4843-52
M.Y. Fessing, A.N. Mandrayev, M.R. Gdula, A.A. Sharov, T Sharova, V. Rapisadra, K.B. Gordon, A.D Smorodchenko, K. Poterlowicz, G. Ferone, Y. Kohwi, C. Missero, T. Kohwi-Shigematsu and V.A. Botchkarev “p63 Regulates Satb1 to control Tissue-Specific Chromatin Remodeling during Development of the Epidermis”, Journal of Cell Biology, 2011 Sep;194(6):825-39.
M.Y. Fessing, R. Atoyan, B. Shander, A.N. Mandrayev, V.V. Jr Botchkarev, K. Poterlowicz, Y. Peng, T. Efimova and V.A. Botchkarev “Bmp signaling induces cell-type specific changes in gene expression programs of human keratinocytes and fibroblasts”, Journal of Investigative Dermatology, 2010 Feb;130(2):398-404.
In the News/Media
Best Paper Prize at the World Congress of Hair Research, Edinburgh, 4-6 May 2013