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Dr Farshid Sefat

Dr Farshid Sefat

  • Title: Lecturer in Medical Engineering
  • Email: F.Sefat1@Bradford.ac.uk
  • Extension: 3679
  • Room No. Chesham C2.19
  • Qualifications: BSc (Hons): Radiology, BEng (Hons): Medical Engineering (UK), MSc: Cell and Tissue Engineering (UK), PhD: Bone Cell Engineering (UK),
  • Additional Role: Course Leader - Tissue Engineering and Wound Repair
  • Additional Role: Course Leader - Cell and Tissue Biology
  • Research Groups: Medical Engineering

BIOGRAPHY +

Farshid Sefat is a lecturer in Medical Engineering at the University of Bradford and Visiting Professor at Stevens Institute of Technology (New Jersey, USA). Previously he was Head of Biomedical Engineering Department at King Faisal University (Saudi Arabia). He completed his post doctorate research assistant at University of Sheffield (UK) in the area of cornea tissue engineering. He received his Ph.D. (2011) and BEng. (2005) degrees from University of Bradford (UK) both in Biomedical Engineering. He also obtained his MSc. (2006) in Biomedical Engineering (Cell and Tissue Engineering) from Keele University, (UK).

His research is based on developing biomaterials to control cellular behaviour with particular emphasis in developing engineered materials for tissue engineering.

Key areas of research interest:

1. Skin, Hair, Breast and Cornea Tissue Engineering
2. Oral/Dental Tissue Engineering
3. Bone and Cartilage Cell Engineering
4. Dental Biomaterials
5. Biomaterials Fabrication & Characterization
6. Effect of Mechanical Stimulation on Bone Cell Behaviour
7. Effects of Growth Factors on Cell Behaviour (Cell Signalling)
8. Synthesis of Antibacterial Peptides for Dental Implant Modification

Current research areas include:

1. Optimisation of layer-by-layer 3D scaffold for dermal wound healing
2. Fabrication and characterisation of biodegradable scaffolds for cornea tissue engineering
3. Cell signalling pathways of Transforming Growth Factor Beta (TGF-β isomers)
4. Investigating breast cancer behaviour using tissue engineering scaffolds
5. Electrospun nanofibers for dental applications
6. Functional scaffolds for periodontal regeneration

GRANTS +

Current, and significant recent, funded projects

1- Internal grant application – (£30,000.00) (Funded)
Fund granted to purchase Electrospinning equipment
Title: Development of Electrospun Scaffolds for Soft and Hard Tissue Engineering

2- IKC Medical Technologies - Proof of Concept Award (£100,000) (Provisionally Accepted)
Title: Functional composite scaffold for local drug delivery in situ postoperatively in breast cancer patients

3- Newton Fund – Grant applied for Participate in UK-China Researcher Links Workshop (£2000) (Accepted)
Title: Healthcare Technologies for Aging Populations 6-8 December 2016

4- Newton Fund – UK-China Researcher Links Workshop (£1800) (Accepted)
Title: The Polymer Graphene Nano Composite Electrode for Wearable Stroke Rehabilitation

5- Newton Fund – UK-China Researcher Links Workshop (£1800) (Accepted)
Title: Investigate Structural & Processing Variations to Address Challenges of Drug Delivery & Stability

Applications submitted and under consideration

1- AD-RKT/UOB - Capacity Development Grant (£10,000) (Submitted)
Title: Application of Synthetic Cannabinoids as New Anti-inflammatory Antibiotic Agents in Wound Repair for Cartilage and Bone

2- AD-RKT/UOB - Capacity Development Grant (£12,000) (Submitted)
Title: Development of Electrospun Scaffold for soft tissue engineering

3- CRUK grant application (£468,565) (Submitted)
Title: Functional composite scaffold for local drug delivery in situ postoperatively in breast cancer patients

AWARDS AND RECOGNITION +

2013 - Best Paper award for 4th International Conference on Biotechnology, Leeds, UK.

2011 - Best Paper award for 13th Annual White Rose Meeting, Biomaterial and Tissue Engineering group (BITEG), Sheffield, UK.

2010 - Best paper award of World Congress of Engineering (WCE 2010), London, UK. Paper title: The Effect of Different HCl Concentrations on Wound Healing of Bone Cell Monolayer.

2010 - Best paper award of World Congress of Engineering (WCE 2010), London, UK. Paper title: The Effect of Transforming Growth Factor Beta (TGF-β3) and Sanicle on Wound Healing.

2009 - Best paper award of World Congress of Engineering (WCE 2009), London, UK. Paper title: The Effect of TGF-β3, HCl and BSA/HCl on Trypsinisation of Bone Cells Monolayer.

2009 - Best paper award of World Congress of Engineering (WCE 2009), London, UK. Paper title: The Anti-Scarring Properties of TGF-β3, BSA/HCl and HCl in Cultured Human Bone Cell Monolayer.

INTERNATIONAL SCIENTIFIC ACTIVITIES +

EDITORIAL BOARD

1) New International Journal of Pharmaceutics [Editor]
2) MOJ Cell Science & Report, Med Crave Publishing Group [Editor]
3) Journal of Trauma and Acute Care [Editor]
4) Journal Trauma & Treatment [Editor]

REVIEWER

1) Acta Biomaterialia [Reviewer]
2) Materials Science and Engineering C [Reviewer]
3) Wound Repair and Regeneration [Reviewer]
4) Journal of Orthopaedics & Rheumatology [Reviewer]
5) Wound Medicine [Reviewer]
6) Journal of Biomechanics [Reviewer]
7) Journal of Controlled Release [Reviewer]
8) Journal of Membrane Science [Reviewer]
9) Medical Engineering & Physics [Reviewer]
10) Bone [Reviewer]
11) J of Mechanical behaviour of Biomedical Materials [Reviewer]
12) Materials Today [Reviewer]
13) Journal of Trauma & Treatment [Reviewer]
14) Journal of Osteoporosis & Physical Activities [Reviewer]
15) Journal of Physical Medicine & Rehabilitation [Reviewer]
16) Journal Of Nuclear Medicine & Radiation Therapy [Reviewer]
17) Second Middle East Conference on Biomedical Engineering (MECBME), IEEE [Reviewer]
18) Journal of Reproduction and Infertility, Official Journal of Avicenna Research Institute [Reviewer]

INTERNATIONAL PROFILE +


International Conference Organisation


RESEARCH STUDENTS +

PhD Students:
----------------
1) Ramisha Rehman
2) Morteza Bazgir

MEng. Students:
---------------
1) Dami Agbabiaka
2) Payal Kaur

U/G Students:
-------------
1) Tehmeena Israr Raja
2) Charlotte Taylor
3) Kandeel Anwar
4) Joshua Dowling
5) Mehreen Zia
6) Nikoshya Vas
7) Zahraa Alturkamani

Visiting Research Fellow
------------------------
Zohreh Arabpour

PUBLICATIONS

Published Books +

Journal Publications +

  • SEFAT F, MAHJOUR B, POLUNIN Y, WANG L and WANG L (2016): "Improved cell infiltration of electrospun nanofiber mats for layered tissue constructs" J Biomed Mater Res A, Wiley.
    For more information see: http://www.ncbi.nlm.nih.gov/pubmed/26845076
  • ZAFAR M, NAJEEB S, KHURSHID Z, NAJEEB B and SEFAT F (2016): "Potential of Electrospun Nanofibers for Biomedical and Dental Applications " Materials, MDPI, 9 (2).
    For more information see: http://www.mdpi.com/1996-1944/9/2/73
  • MAHJOUR B, FU X, YANG X, SEFAT F and WANG H (2015): "Rapid creation of skin substitutes from human skin cells and biomimetic nanofibers for acute full-thickness wound repair" Burns, Elsevier, 41 (8): 1764–1774.
    For more information see: http://www.sciencedirect.com/science/article/pii/S0305417915001837
  • SEFAT F, KHAGHANI S.A., NEJATIAN T, GENEDY M and YOUSEFFI M (2015): "Transforming Growth Factor Beta (TGF-β) Isomers Influence Cell Detachment of MG-63 Bone Cells" Tissue and Cell, Elsevier, 47 (6): 567-574.
    For more information see: http://www.ncbi.nlm.nih.gov/pubmed/26372305
  • DESHPANDE P, ORTEGA I, SEFAT F, SANGWAN V.S. and MACNEIL V.S. (2015): "Rocking Media Over Ex Vivo Corneas Improves This Model and Allows the Study of the Effect of Proinflammatory Cytokines on Wound Healing" Invest Ophthalmol Vis Sci., 56 (3): 14-15308.
    For more information see: http://www.ncbi.nlm.nih.gov/pubmed/25655804
  • NEJATIAN T, SEFAT F and JOHNSON T (2015): "Impact of Packing and Processing Technique on Mechanical Properties of Acrylic Denture Base Materials" Materials, MDPI, 8 (5): 2093-2109.
    For more information see: http://www.mdpi.com/1996-1944/8/5/2093
  • ORTEGA I, SEFAT F, DESHPANE P, PATERSON T and MACNEIL T (2014): "Combination of microstereolithography and electrospinning to produce membranes equipped with niches for corneal regeneration" J Vis Exp.
    For more information see: http://www.ncbi.nlm.nih.gov/pubmed/25285843
  • SEFAT F, DENYER M and YOUSEFFI M (2014): "Effects of Different Transforming Growth Factor Beta (TGF-β) Isomers on Wound Closure of Bone Cell Monolayers" Cytokine, Elsevier, 69 (1).
    For more information see: http://www.ncbi.nlm.nih.gov/pubmed/25022965
  • BYE F.J., BULLOCK A.J., SINGH R, SEFAT F and MACNEIL S (2014): "Development of a Basement Membrane Substitute Incorporated Into an Electrospun Scaffold for 3D Skin Tissue Engineering " Journal of Biomaterials and Tissue Engineering, American Scientific Publishers , 4.
  • DESHPANDE P, RAMACHANDRAN C, SEFAT F, RYAN A.J. and MACNEIL A.J. (2013): "Simplifying corneal surface regeneration using a biodegradable synthetic membrane and limbal tissue explants" Biomaterials, Elsevier, 34 (21): 5088-106.
    For more information see: http://www.ncbi.nlm.nih.gov/pubmed/23591389
  • SEFAT F, MCKEAN R, DESHPANE P, RAMACHANDRAN C and MACNEIL S (2013): "Production, Sterilisation and Storage of Biodegradable Electrospun PLGA Scaffolds for Delivery of Limbal Stem Cells to the Cornea" Procedia Engineering, Elsevier, 59 101–116.
    For more information see: http://www.sciencedirect.com/science/article/pii/S1877705813010138
  • SEFAT F, DENYER M.C. and YOUSEFFI F (2011): "Imaging via widefield surface plasmon resonance microscope for studying bone cell interactions with micro-patterned ECM proteins" J Microsc, Wiley, Oxford, 241 (3): 282-90.
    For more information see: http://www.ncbi.nlm.nih.gov/pubmed/21118224

Chapters in Books +

  • SEFAT F, YOUSEFFI M and DENYER M (2010): "Biological Application of Widefield Surface Plasmon Resonance Microscope to Study Cell/Surface Interactions and the Effect of TGF-β3, HCl and BSA/HCl on Cell Detachment Assay of Bone Cells Monolayer", Electronic Engineering and Computing Technology, Springer, Netherlands ISBN: 978-90-481-8775-1, pp. 575-583.
    For more information see: http://link.springer.com/chapter/10.1007%2F978-90-481-8776-8_49
  • SEFAT F, YOUSEFFI M and DENYER M (2010): "Application of a Novel Widefield Surface Plasmon Resonance Microscope in Cell Imaging and Wound Closure Properties of TGF-β3, BSA/HCl and HCl in Cultured Human Bone Cell Monolayer", Electronic Engineering and Computing Technology, Springer, Netherlands ISBN: 978-90-481-8775-1, pp. 585-595.
    For more information see: http://link.springer.com/chapter/10.1007%2F978-90-481-8776-8_50
Profile last updated on: 10-03-2017

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