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Drug Metabolism and Pharmacokinetics

We offer expertise in the following areas:

Pharmacokinetic evaluation of preclinical tissue samples

  • Full pharmacokinetic profiles of drug and metabolites including tissue distribution
  • Metabolite identification
  • Bioavailability studies (iv, ip, po) 
  • In vitro metabolism studies 
  • Protein binding
  • Pharmacodynamic evaluation of preclinical tissue samples
  • Analytical method development with HPLC and LC MS/MS
  • Full ADME studies including the use of recombinant enzymes
  • Cell uptake and tissue distribution of naturally fluorescent/fluorescently tagged agents by confocal microscopy 

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Pharmacodynamic evaluation of preclinical tissue samples

  • DNA strand breaks of cross linking by Comet assay
  • Cell cycle analysis by flow cytometry and immunohistochemistry
  • Cell death analyses by flow cytometry/immunohistochemistry/TUNEL assay
  • LC MS/MS of small molecule biomarkers 
  • Cytoskeleton disruption by immunohistochemistry

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Pharmacokinetic and Pharmacodynamic evaluation of clinical samples

  • Validated analytical methods development to Good Clinical Laboratory Practice (GCLP)
  • Full clinical pharmacokinetic reports 
  • Analysis of clinical tissue samples for drug and metabolites 
  • Evaluation of clinical pharmacodynamic endpoints

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Further information

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