Dr Krzysztof Poterlowicz

PositionLecturer in Bioinformatics
LocationH38f-j, Richmond Building
Department or DivisionFaculty of Life Sciences
RKT CentreCentre for Skin Sciences
Telephone(01274) 234732
EmailK.Poterlowicz1@bradford.ac.uk
Twitter@@bioinfbrad
LinkedIn ProfileVisit my LinkedIn profile
ORCID000-0001-6173-5674

Research Interests (key words only)

Bioinformatics, Biostatistics, Digital health, Epigenetics, Genomics, Skin

Knowledge Transfer Activity

Biostatistics and Bioinformatics analysis (mRNA and miRNA microarrays, ChIP-Seq, RNA-Seq processing and downstream analysis)

PhD Supervision

Dr Kirsty Smith (2016- ) together with Profesor Desmond Tobin

Teaching and Supervisory Responsibilities

  • BM-3008K Research Project
  • BM-3123D Medical Genetics
  • BM-9132L Reasearch and Analytical Methods
  • CS-1001L Special Studies 1
  • CS-5004L Special Studies 2
  • CS-5001D Genetics and Health
  • CS-6003K Special Studies and PPD3
  • PH-4039D Computational Pharmaceutics and Knowledge Management
  • Personal Tutor (Biomedical Sciences)

Biography

Dr Poterlowicz graduated in mathematics and applied statistics at the Wroclaw University in Poland. He further continued his education at the University of Bradford studying computational modelling of the yeast cell cycle and obtained a MPhil degree in Bioinformatics. 

In 2009 he visited the Biotechnology Research Institute of the National Research Council Canada where his research involved computer simulation of molecular signalling cascades governing the development and differentiation of skin appendages. 

In 2010 he was awarded a ESPRC PhD fellowship in the Centre of Skin Sciences,  University of Bradford. This allowed him to develop an expertise in bioinformatics and computational biology of transcriptional and epigenetic regulation in the epidermis. His PhD research project on the  bioinformatics analyses of multi-level transcriptional  and epigenetic regulation of  epidermis together with internal and external collaborations resulted in a number of published articles in journals such as Journal of Cell Biology, FASEB, Development and Journalof Investigative Dermatology. Dr Poterlowicz was awarded the Best Paper Prize at the World Congress of Hair Research in Edinburgh in 2013. The same year he joined the Faculty of Life Sciences at the University of Bradford asa Lecturer in Bioinformatics. Dr Poterlowicz teaches computational biology, medical genetics and statistics and actes as a personal tutor to first year students of the biomedical science undergraduate program. He is a research active academic with interest in the identification of novel genomics biomarkers that influence tissue development and disease. He is involved in the international scientific collaborations (MRC UK-China Stem Cell Partnership Initiative grant) and his research is regulatory published in peer-review journals. Dr Poterlowicz actively works in the international   focus groups with aim to develop and provide bioinformatics and medical informatics training for biomedical students and staff. He is an Associate Member of the EpiGenSys and a Member of the Royal Society of Biology.

Study History

  • University of Bradford, School of Life Sciences (PhD, 2013)
  • University of Bradford, School of Computing, Informatics and Media (MPhil, 2010)
  • University of Wroclaw, Institute of Mathematics (MSc, 2005)

Professional Activities

  • Reviewer of the Journal of Investigative Dermatology
  • Associate Member of the EpiGenSys
  • Member of the Royal Society Biology
  • Associate Fellow of the Higher Education Academy (AFHEA)

Research Areas

  • Bioinformatics of Genomics and Epigenomics- Epigenomics of the Skin development and Disorders- Big biomedical Data Analytics
  • Development of bioinformatics worflows

Current Projects

  • The Galaxy workflow for epigenetic profiling of progressing melanoma
  • 3D modelling of the genome
  • Network modelling of miRNA-mRNA interactions during Hair Cycle

Networks/Roles

Publications

Mardaryev AN, Liu B, Rapisarda V, Poterlowicz K, Malashchuk I, Rudolf J, Sharov AA, Jahoda CA, Fessing MY, Benitah SA, Xu GL, Botchkarev VA. "Cbx4
maintains the epithelial lineage identity and cell proliferation in the developing stratified epithelium". J Cell Biol. 2016


Ahmed MI, Alam M, Emelianov VU, Poterlowicz K, Patel A, Sharov AA, Mardaryev, AN, Botchkareva NV. "MicroRNA-214 controls skin and hair follicle development by modulating the activity of the Wnt pathway". J Cell Biol. 2014

T.Y. Sharova,K. Poterlowicz, N.V. Botchkareva , N.A. Kondratiev, A. Aziz, J.H. Spiegel, V.A. Botchkarev, A.A. Sharov "Complex changes in the apoptotic and cell differentiation programs duri ng initiation of the hair follicle response to chemotherapy" , Journal of Investigative Dermatology, 2014

 

A.N. Mardaryev, M.R. Gdula , J.L. Yarker , V.N. Emelianov, K. Poterlowicz , A.A. Sharov, T.Y. Sharova, J.A. Scarpa, P. Chambon, V.A. Botchkarev, M.Y. Fessing "p63 and Brg1 control developmentally regulated higher-order chromatin remodelling at the epidermal differentiation complex locus in epidermal progenitor cells", Development, 2014

 

C.J. Lewis, A.N. Mandrayev, K. Poterlowicz, T.Y. Sharova, A. Aziz, D.T. Sharpe, N.V. Botchkareva, A.A Sharov “Bone Morphogenetic Protein Signalling Suppresses wound-Induced Skin Repair by Inhibiting Keratinocyte Proliferation and Migration”, Journal of Investigative Dermatology, 2013

 

M.R. Gdula, K. Poterlowicz, A.N. Mandrayev, A.A. Sharov, Y. Peng, M.Y. Fessing, V.A. Botchkarev “Remodelling of three-dimensional organization of the nucleus during terminal keratinocyte differentiation in the epidermis”, Journal of Investigative Dermatology, 2013

 

T. Kohwi-Shigematsu, K. Poterlowicz, E. Ordinario, H.J. Han, V.A. Botchkarev, Y. Kohwi “Genome organizing function of SATB1 in tumor progression.” Seminars in Cancer Biology, 2012 

 

J. Laubenthal, O. Zlobinskaya*, K. Poterlowicz*, M.R. Gdula, J.O. Linschooten, E. Fthenou, A. Baumgartner, F.J. van Schooten, T.E. Schmid, R.W. Godschalk and D. Anderson “Cigarette smoke-induced transgenerational alterations in genome stability in cord blood of human F1 offspring”, FASEB, 2012 Oct:26(10):3946-56 (* equal contribution) 

 

K.M. McMahon, M. Volpato, H.Y. Chi, P. Musiwaro, K. Poterlowicz, Y. Peng, A.J. Scally, L.H. Patterson, R.M. Phillips, C.W. Sutton “Characterization of changes in the proteome in different regions of 3D multicell tumor spheroids” Journal of Proteome Research, 2012 May;11(5):2863-75 

 

A.N. Mandrayev, N. Meier, K. Poterlowicz, A.A. Sharov, T. Sharova, M.I. Ahmed, V. Rapisarda, C. Lewis, M.Y. Fessing, T.M. Ruenger, J. Bhawan, S. Werner, R. Paus and V.A. Botchkarev “Lhx2 differentially regulates Sox9, Tcf4 and Lgr5 in hair follicle stem cells to promote epidermal regeneration after Injury” Development, 2011 Nov;138(22):4843-52 

 

M.Y. Fessing, A.N. Mandrayev, M.R. Gdula, A.A. Sharov, T Sharova, V. Rapisadra, K.B. Gordon, A.D Smorodchenko, K. Poterlowicz, G. Ferone, Y. Kohwi, C. Missero, T. Kohwi-Shigematsu and V.A. Botchkarev “p63 Regulates Satb1 to control Tissue-Specific Chromatin Remodeling during Development of the Epidermis”, Journal of Cell Biology, 2011 Sep;194(6):825-39.

 

 M.Y. Fessing, R. Atoyan, B. Shander, A.N. Mandrayev, V.V. Jr Botchkarev, K. Poterlowicz, Y. Peng,  T. Efimova and V.A. Botchkarev “Bmp signaling induces cell-type specific changes in gene expression programs of human keratinocytes and fibroblasts”, Journal of Investigative Dermatology, 2010 Feb;130(2):398-404. 

In the News/Media

Best Paper Prize at the World Congress of Hair Research, Edinburgh, 4-6 May 2013

Share this