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Prof Diana Anderson

PositionProfessor of Biomedical Science and Established Chair
LocationRoom H38A, Richmond Building
Academic SchoolSchool of Life Sciences
Department or DivisionBradford School of Medical Sciences
Telephone(01274) 233569
Emaild.anderson1@bradford.ac.uk

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Research Interests (key words only)

cancer, oxygen radicals, human biomonitoring, unbalanced precursor pools, dietary imbalance, male-mediated developmental defects, nanotoxicology, general toxicology

Study History

  • BSc, University of Wales, UK (Faculty of Science) 1963
  • MSc, University of Manchester, UK (Faculty of Medicine) 1971
  • PhD, University of Manchester, UK (Faculty of Medicine) 1973
  • DipEd, University of New England, NSW, Australia (Faculty of Education) 1965
  • C.Biol FIBiol, Chartered biologist and Fellow of the Institute of Biology, UK, 1983-2009
  • FATS, Fellow of the Academy of Toxicological Sciences, USA, 1988
  • FIFST, Fellow of the Institute of Food Science and Technology, UK, 1989
  • FRCPath, Fellow of Royal College of Pathologists, UK, 1992
  • ILT-M Institute for Learning and Teaching in Higher Education, 2002
  • FHEA, Fellow of the Institute for Learning and Teaching in Higher Education, 2002
  • FRSM, Fellow of the Royal Society of Medicine, 2007
  • FSB, Fellow of the Society of Biology, 2009
  • FRSC, Fellow of the Royal Society of Chemistry, 2010
  • Entrant in: Indicative Register of Genetic Toxicologists; Biologists in Health Care; European Register of Toxicologists.

Professional History

  • Professor, Established Chair and Research Co-ordinator in the Department of Biomedical Sciences, University of Bradford, Bradford, UK, 2000 – to date
  • Head of Educational Services, TNO BIBRA International, 1999 - 2000
  • Senior Associate, Co-ordinator of External Affairs, BIBRA International, 1992 - 1999
  • Assistant Director and Co-ordinator of Group Forum/External Affairs, BIBRA International 1987 - 1992
  • Research Manager for Genetic and Reproductive Toxicology, BIBRA, 1987-2000
  • Head of Genetic and Reproductive Toxicology, BIBRA, 1981 - 1987
  • Head of Mutagenesis Studies at Central Toxicology Laboratory, ICI Ltd, Alderley Park, Cheshire, UK 1974 - 1981
  • Research worker - Paterson Laboratories, Christie Hospital, University of Manchester, UK 1970 - 1974
  • Lecturer in Biology, Didsbury Training College, Manchester, UK 1969 - 1970
  • Research Assistant, Department of Cancer Studies, Leeds University, UK 1968 - 1969
  • Tutor in School of Biological Sciences, Sydney University, New South Wales, Australia, 1965 - 1968
  • Lecturer, Llandaff Technical College, Cardiff, UK, 1963 - 1964.

 

Professional Activities

  • Secretary of UKEMS (1977 - 1984)
  • Secretary to Accreditation Committee of UKEMS (1983 - 1991)
  • member of Nominating Committee of EEMS (1979 - 1981; 1985 - 1988; 1995 - to date)
  • EMS Councillor (1987 - 1990)
  • member of Nominating Committee of EMS (1990 - 1995)
  • member of Scientific Sub-committee of British Toxicology Society (1984 –1989) and Executive Committee member (1991 - 1997)
  • member of IAEMS Infrastructure Committee (1999 -to date)
  • Director of Board of Academy of Toxicological Sciences, USA (1998 - 2001)
  • Vice-President of the Institute of Biology (1987 - 1989) and Chairman of its Biomedical Sciences Division (1987-1992)
  • Chief Examiner of the International Diploma in Toxicology (1989 - to date)
  • member of Health Advisory Committee, Council of Science and Technology Institutes (1986 - 1997)
  • member of Court of Governors, Swansea University College (1989 - 1995)
  • member of DHSS Committee on Mutagenicity of Chemicals in Food Consumer Products and the Environment (1985 - 1989)
  • EU Scientific Committee for Animal Nutrition (1999-2003)
  • MRC Advisory Board (2003 – 2006)
  • Chairman of the Scientific Steering Committee of IAEMS Foundation (1999 - 2006)
  • Member of editorial board of 8 international journals, including Teratogenesis, Carcinogenesis and Mutagenesis (1992-2003) and Mutation Research Reviews (1999 to date), also a member of editorial board of two online journals
  • external examiner for the Dept. of Genetics, University of Wales, Swansea (2006 - 2010)
  • I have hosted and participated in (as Chair, Rapporteur or participant) 56 meetings on behalf of WHO/IPCS.
  • I was Chair of the IPCS meeting for Human Monitoring Guidelines; member of the EMS/OECD Work Group to establish Guidelines for the Comet Assay; Course Director - NATO Advanced Study Institute 1999; consultant to EU, UNIDO, British Council, TWAS, OECD, NATO and multinationals.

Publications

Published over 400 papers; edited/authored 8 books; series editor for “Current Toxicology” J Wiley and Sons and “Issues in Toxicology” Royal Society of Chemistry; editor of 4 special issues in Mutation Research, 1 of Enviromental and Molecular Mutagenesis, 3 of Teratogenesis, Carcinogenesis and Mutagenesis and part of one for Mutagenesis.

Publications from 2006 onwards:

  • Cemeli E, Wagner ED, Anderson D, Richardson SD and Plewa MJ (2006). Modulation of the cytotoxicity and genotoxicity of the drinking water disinfection by-products iodoacetic acid by suppression of oxidative stress. Environmental Science and Technology 40 1878-1883
  • Schallreuter K U, G.Chuichiarelli, E Cemeli, SM Elwary, JM Gillbro, J D Spencer, H Rokos, A Panske, B Chawan, JM wood and D Anderson (2006). Oestrogens can contribute to hydrogen peroxide generation and quinine–mediatedDNA damage in peripheral blood lymphocytes from patients with vitiligo. Journal of Investigative Dermatology 126 1036-1042
  • Ruf A A, Cuthbert A C, Foroutan B and Anderson D (2006). p53 Expression in haematological malignancies: Response to alkylating agent in the Comet Assay Journal of Preventive Medicine.  14 (1-2) 32-45
  • Gopalan R C, Nelson L D, Thornton J M and Anderson D (2006). Effects of the sexhormones and their modulators on DNA damage in skin cells measured in the Comet assay Journal of Preventive Medicine. 14 (1-2)14-31
  • Natalie Wyatt, Christine Kelly, Vincenzo Fontana, Domenico Franco Merlo, Donald Whitelaw and Diana Anderson (2006).The responses of lymphocytes from Asian and Caucasian diabetic patients and non-diabetics to hydrogen peroxide and sodium nitrite in the Comet assay.Mutation Res 609 154-164

2007

  • Foroutan B, Ruf AA, Jerwood D and Anderson D (2007). In vitro studies of DNA damage and its repair in cells from NHL patients with p53 mutated protein status. Jnl of Pharmacological and Toxicological Methods55 58 -64
  • Foroutan B, Ruf AA, Costall B and Anderson D (2007). An in vitro model to study chemoresistance in NHL patients over-expressing mutant p53. Jnl of Pharmacological and Toxicological Methods55 151-158
  • Wyatt  NP, Falque-Gonzalez C, Farrar D,Tuffnell D, Whitelaw D, Knudsen L E and Anderson D (2007) In vitro susceptibilities in lymphocytes from mothers and cord blood to the monofuncional  alkylating agent EMS. Mutagenesis22, 123-127
  • Schmid TE, Eskenazi B  Baumgartner A, Marchetti F, Young S, Weldon R, Anderson D and Wyrobek AJ (2006) The effect of male age on sperm DNA damage in healthy non - smokers. Human Reproduction22 180-187
  • Kapka L, Baumgartner A, Siwinska E, Knudsen L E, Anderson D and Mielzynska D (2007) Environmental Lead exposure increases micronuclei in children Mutagenesis 22(3) 201-207
  • Anderson D, Cemeli E, Schmid TE, Baumgartner A, Brinkworth M and Wood JH Oestrogenic Compounds and Oxidative Stress. In Anderson D and Brinkworth M (Eds) (2007) Male-mediated Developmental Toxicity. Royal Society of Chemistry, Cambridge pp.259-272
  • Mojgan Najafzadeh, P. Dominic Reynolds, Adolf Baumgartner, David Jerwood and Diana Anderson (2007) Chaga mushroom extract inhibits oxidative DNA damage in lymphocytes of patients with inflammatory bowel disease (IBD) Biofactors 31 191-2007
  • Anderson D and Brinkworth M (Eds) (2007) Male-mediated Developmental Toxicity. Royal Society of Chemistry, Cambridge pp 1-292

2008

  • Alok K. Pandey, Mahima Bajpayee, Devendra Parmar, Rakesh Kumar, Subodh K. Rastogi, Neeraj  Mathur, Paul Thorning, Marcel de Matas, Qun Shao, Diana Anderson, and Alok Dhawan (2008) Multipronged Evaluation of Genotoxicity in Indian Petrol-Pump Workers. Environmental and Molecular Mutagenesis  49 695-707
  • Schallreuter K, Rokos H, Chavan B, Gillbro JM, Cemeli C, Zathner C, Anderson D, WoodJM (2008) Quinones are reduced by 6 tetra hydrabiopterinin human keratinocytes, melanocytes and melanoma cells. Free Radical Biology and Medicine 44 538-546

2009

  • Baumgartner A, Cemeli E, Anderson D 2009(2009) The Comet assay in male reproductive  toxicology. Cell Biology and Toxicology  25  81-89
  • Cemeli E, Baumgartner A, Anderson D.Antioxidants and the Comet assay (2009) Mutation Research 681, 56-67
  • Mojgan Najafzadeh, P. Dominic Reynolds, Adolf Baumgartner, David Jerwood and Diana Anderson. (2009) Chaga mushroom extract inhibits oxidative DNA damage in lymphocytes of  patients with inflammatory bowel disease (IBD) Biofactors 31 191-200
  • Eduardo Cemeli, Giorgia Chiuchiarelli, Ekaterina Mirkova and Diana Anderson(2009) Investigation on the mechanisms of genotoxicity of butadiene, styrene and their combination in human lymphocytes using the Comet assay. Mutation Research  664 69-76
  • Ilse Decordier, Alexander Papine, Gina Plas, Sam Roesems, Kim Vande Loock, Jennifer Moreno Palomo,Eduardo Cemeli, Diana Anderson, Aleksandra Fucic, Ricardo Marcos, Françoise Soussaline and  Micheline Kirsch-Volders (2009) "Automated image analysis of cytokinesis-blocked micronuclei: an adapted protocol and a validated scoring procedure for biomonitoring." Mutagenesis 24, 85-93
  • Gopalan RC, Osman IF, Amani A, de Matas M and Anderson D (2009). The effect of zinc oxide and titanium dioxide nanoparticles in the Comet assay with UVA photoactivation of human sperm and lymphocytes. Nanotoxicology 3 (1), 33-39
  • Mojgan Najafzadeh, P. Dominic Reynolds, Adolf Baumgartner, and Diana Anderson (2009) Flavanoids inhibit the mutagenicity of H202 and the food mutagen IQ (2-amino-3- methylimadazo[4,5-f]quinoline) lymphocytes of patients with Inflammatory Bowel Disease (IBD) Mutagenesis 24 405-411
  • Anderson D., Baumgartner A., Cemeli C. (2009) Cytogenetics. In: General and Applied Toxicology 3rd ed. Eds. Ballantyne B., Marrs T. and Syversen T., John Wiley & Sons, Chichester, West Sussex, UK pp 1683-1710
  • Eastmond DA, Hartwig A, Anderson D, Anwar WA, Cimio MC, Dobrev I, Douglas GR, Nohmi T, Phillips DH, Vickers C. Mutagenicity testing for chemical risk assessment update of the WHO/IPCS Harmonised Scheme. Mutagenesis (2009) 4: 341-349   
  • Baumgartner A., Cemeli C., Anderson D. (2009) The Sperm Comet Assay - Assessing Genotoxins in Male  Germ Cells. In: The Comet assay in Toxicology, eds. Dhawan A. and Anderson D., RSC, Cambridge, UK pp 331-369
  • Lindschooten JO,  Van Schooten FJ,  Baumgartner A, Cemeli E, Van Delft J, Anderson D, and Godschalk  RWL.(2009) Use of spermatozoal mRNA profiles to study gene-Environment Interactions in human germ cells. Mutation Research 24(1) 85-93

2010

  • Sipinen V, Laubenthal J,  Baumgartner A ,Cemeli E,  Linschooten JO, Godschalk R W L, Van Schooten F-J, Anderson D and Brunborg G (2010) In vitro evaluation of baseline and induced DNA damage in human sperm exposed to benzo[a]pyrene or its metabolite benzo[a]pyrene-7,8-diol-9,10-epoxide, using the comet assay.Mutagenesis 4:417-425.
  • Valdiglesias V, Mendez J, Pasaro E, Cemeli E, Anderson D, Laffon B (2010) Assessment of okadaic acid effects on cytoxicity, DNA damage and DNA repair in human cells. Mutation Res 689(1-2):74-79
  • Anderson D (2010) Commentary: A European perspective on the role of EMS Societies. How do they help Public Health and Research and the Development of Regulations. Environmental and Molecular Mutagenesis 51(8-9) 761-762
  • Osman IF, Baumgartner A, Cemeli E, Fletcher JN, Anderson D (2010) Genotoxicity and Cytoxicity of zinc oxide and titanium dioxide in Hep2 cells. Nanomedicine 5(8) 1193-2203
  • Anderson D. Short Term Assays in Human Monitoring of Health Risk from Genotoxic Exposures. (Eds)  A Cebulska–Wasilewska, AN Osipov, F Diroudi  In: Rapid Diagnosis in Populations at Risk from Radiation and Chemicals. NAT0 IOS Press  Amsterdam (2010) pp. 9-15
  • Anderson D. Heritable  versus Somatic Effects in vivo and in vitro (Eds) A Cebulska-Wasilewska, AN Osipov, F Diroudi  In: Rapid Diagnosis in Populations at Risk from Radiation and Chemicals. NAT0 IOS Press  Amsterdam (2010),pp. 65-77
  • Osman IF, Jacob BK, Anderson D. (2010) Effects of nanoparticles on human cells from healthy individuals and patients with respiratory diseas J.Biomedical  Nanotechnol.7,26-27

2011

  • Sharma V, Singh SK, Anderson D, Tobin DJ, Dhawan (2011) A. Zinc oxide nanoparticle. Induced genotoxicity in primary epidermal keratinocytes. Journal of Nanoscience and Nanotechnology. 11, 1-7
  • Valdiglesias V, Llafon B, Pasara E, Cemeli E, Anderson D, Mendez J. (2011) Induction of Oxidative DNA damage by the marine toxin okadaic acid depends on human cell type. Toxicon 57, 882-888
  • Cemeli E, Anderson D.(2011) Mechanistic investigation of ROS-induced DNA damage by oestrogenic compounds in lymphocytes and sperm using the Comet assay. International Journal Molecular Science 12 (5) 2783-2796
  • Najafzadeh, M. Kurzawa-Zegota, M. Baumgartner, A. Reynolds, D. Davies JB and Anderson D. (2011) The effect of flavonoids in soybean products on lymphocytes from IBD and colon cancer patients after treatment with food mutagens and hydrogen peroxide. In Soybean and Health. Ed Hany EL Shany Book 4. Intech Open Access Publisher.pp79-102 ISBN 978-953-307-535-8
  • Behzad Foroutan, Adolf Baumgartner, Afruj Ali Ruf, Diana Anderson (2011)Molecular Cytogenetic analysis of drug resistant Non-Hodgkin’s Lymphoma (NHL) patients with p53 abnormalitie using Comparative Genomic Hybridisation (CGH) and Fluorescence in situ Hybridisation (FISH) Archives of Iranian Medicine 14(5) 321-326
  • Najafzadeh M, Baumgartner A,  Gopalan  R, Davies J B , Wright A, Reynolds PD, Anderson D. (2011). An in vitro evaluation of differerent sensitivities of patients diagnosed with cancer or a precancerous state by using UVA as a generic mutagen and employing the micronucleus and Comet assay  Mutagenesis.Dec11 1-7 doi:10.1093/mutage/ger087
  • Gopalan RC, Emerce E, Wright CW, Karahalil B, Karakaya AE and Anderson D.(2011)Effects of the  anti-malarial compound Cryptolepine and its analogues in human lymphocytes and sperm in the Comet Assay (2011) Toxicology Letters, 207 322-325

2012

  • Najafzadeh M, Baumgartner A,  Gopalan  R, Davies J B , Wright A, Reynolds PD, Anderson D. (2011). An in vitro evaluation of different sensitivities of patients diagnosed with cancer or a precancerous state by using UVA as a generic mutagen and employing the micronucleus and Comet assay  Mutagenesis(Dec11 1-7 doi:10.1093/mutage/ger087) 27(3)351-357
  • Kurzawa M, M Najafzadeh, P Dominic Reynolds, Anderson D (2012)The protective effect of flavonoids  on food mutagen induced DNA damage in peripheral blood lymphocytes from colon cancer patients. Food and Chemical Toxicology 50 124-129
  • Baumgartner A,  Kurzawa-Zegota M,  Laubenthal J,  Cemeli E,  Anderson D (2012) Comet-assay parameters as rapid biomarkers of exposure to dietary/environmental Compounds-An in vitro feasibility study on spermatozoa and lymphocytes. Mutat Res 743 25-35
  • Alotaibi A,  Baumgartner A, Najafzadeh M, Cemeli E, Anderson D (2012) In vitro investigation of DNA Damage induced by the DNA Cross-linking agents oxaliplatin and satraplatin in lymphocytes of colorectal cancer patients. Journal of Cancer Therapy, 3 78-89
  • Gurbani D, Kuksal V, Laubenthal J, Kumar A, Pandey A,  Tripathi S, Arora A, Jain S.K , Ramachandran R, Anderson D, Dhawan A (2012) Mechanism of Inhibition of the ATPase Domain of HumanTopoisomerase IIa by 1,4-Benzoquinone, 1,2-Naphthoquinone,1,4-Naphthoquinone, and 9,10-Phenanthroquinone Toxicological Sciences 126(2), 372–390 doi:10.1093/toxsci/kfr345
  • Sharma V, Anderson D, Dhawan A (2012) Zinc oxide nanoparticles induce oxidative DNA damage and ROS-triggered mitochondria mediated apoptosisin human liver cells (HepG2) Apoptosis  (8) 852-870           ISSN 1360-8185    DOI 10.1007/s10495-012-0705-6
  • Andrew Collins, Diana Anderson, Erdem Coskun, Alok Dhawan, Maria Dusinska, Gudrun Koppen, Marcin Kruszewski, Massimo Moretti, Emilio Rojas, Günter Speit, Mahara Valverde, Stefano Bonassi. Launch of the ComNet (comet network) project on the comet assay in human population studies during the International Comet Assay Workshop meeting in Kusadasi, Turkey (September 13-16, 2011). Mutagenesis  2012; 27(4):385-6. DOI:10.1093/mutage
  • Julian Laubenthal, Olga Zlobinskaya, Krzysztof Poterlowicz, Adolf Baumgartner, Michal R. Gdula, Eleni Fthenou, Maria Keramarou, Sarah J. Hepworth, Jos C.S. Kleinjans, Frederik-Jan van Schooten, Gunnar Brunborg, Roger W. Godschalk, Thomas E. Schmid and Diana Anderson (2012). Cigarette smoke induced transgenerational alterations in Genome stability in cord blood of human F1 offspring FASEB 26, 3946-3956.
  • Thomas E. Schmid, Brenda Eskenazi, Francesco Marchetti,Suzanne Young, Rosana H. Weldon, Adolf Baumgartner,Diana Anderson, and  Andrew J. Wyrobek,  Micronutrients intake is associated with improved sperm DNA quality in older men.  Fertility and Sterilty 98 (5)1130-1137 I.F. 3.958
  • Bezhad Foroutan and Diana Anderson ( 2012). Assessment and Modulation of Chemoresistance by  different subgroups of sensitisers in a NHL cell line model. Basic and Clinical Cancer Research  (3&4) 15 -21
  • Baumgartner A, Sampol-Lopez M,  Cemeli E,  Schmid TE, Evans AA  Donahue RE and AndersonD. Genotoxicity Assessment of Birch–bark Tar – A most versatile Prehistoric Adhesive. Advances in Anthropology 2012. Vol.2, No.2, 49-56 [ Published Online May 2012 in Scientific Research

2013

  • Anderson D and Phillips JC (2013) Carcinogenic Sustances in Food. In: Caballero B (ed.) Encyclopedia of Human Nutrition. Third Edition. Volume 1. pp 235-241 Waltham, MA: Academic Press
  • Alotaibi A, Bhatnagar P, NajafzadehM, Gupta K and Anderson.D  (2013)Tea phenols in bulk and nanoparticle form modify DNA damage in human lymphocytes from colon cancer patients and healthy individuals treated in vitro with platinum based chemotherapeutic drugs. Nanomedicine (released as e-pub Sept. 4) 8(3) 389-401
  • Anderson DLaubenthal J. Analysis of DNA Damage via Single-Cell Electrophoresis. Ed.Markovets S. Methods in Mol Biol.  2013;1054:209-218. doi: 10.1007/978-1-62703-565-
  • Laubenthal J, Anderson D. Fluorescence in situ hybridization on electrophoresed cells to detect sequence specific DNA damage.Ed Markovets S. Methods in Mol Biol. 2013; 1054:219-235 doi: 10.1007/978-1-62703-565
  • Anderson D, Dhawan A and Laubenthal J.  The Comet Assay in Human Biomonitoring. In Genotoxicity Assessment Methods and Protocols.  Eds. Dhawan A and Bajpayee M. Humana Press (a brand of Springer). 2013 pp 347-362 ISBN 978-1-62703-529-3
  • Laubenthal J, Gdula M R, Dhawan A and Anderson D. Multicolor laser scanning Confocal Immunofluorescence of DNA Damage Response Biomarkers. In Genotoxicity Assessment Methods and Protocols.  Eds. Dhawan A and Bajpayee M. Humana Press (a brand of Springer). 2013 pp 331-324 ISBN 978-1-62703-529-3

2014

  • Anderson D, Thomas E Schmid and Baumgartner A. Male-mediated developmental toxicity. Asian Journal of Andrology (2014) 16, (81–88)
  • Habas K, Anderson D, Brinkworth MH. Development of an in vitro test system for assessment of male reproductive toxicity. Toxicology letters 225 (2014) 86-91 .

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